Study of Dendritic cell- T cell interaction, inflammatory cytokines and antibody response in SARS-CoV-2 (Coronavirus) and Influenza infection:
Immune response against the infections in the vaccinated and non-vaccinated individuals varies with age, gender and other comorbidities. The study done on both the mice model and human samples of nasal swab, rectal swab, serum and PBMC. Maturation, Activation, Differentiation, Proliferation of individual subsets of: Dendritic cells (plasmacytoid and myeloid lineage), B cells, CD4T (including regulatory T cells and Th17 cells), cytotoxic CD8T cells and their crosstalk are being investigated. Inflammatory balance at pro- and anti-inflammatory cytokine level and antibody serotypes, neutralization capacities are also being studied.
Development of universal Nanovaccine against the Respiratory tract infections:
My focus in this project is to develop multiple epitopes decorated nanovaccine for broad range of respiratory infections ranging from multiple strains of influenza, SARS-CoV 2 (coronavirus) and respiratory syncytial virus. This will provide a universal protection against multiple viruses affecting the respiratory tracts and lungs.
Diabetes-mediated remodeling of vaccine efficacy against influenza infection:
Aim is to study how the diabetic individuals are responding to the commercially available influenza vaccines or flu-shots as compared to non-diabetic individuals. The study will shed light for more specific vaccine strategies for the diabetic individuals.
Investigating the influence of psychological stress in regulation of immune response:
The psychological stress influences the neuronal physiology which in turn affects our immune response by altering the immune cells, their receptors and the secreted cytokines. My aim is to evaluate the influence of different stress response in modulating the basal immune response, immunity against the infectious challenge of influenza and the vaccine efficacy in mice model.
PhD thesis work:
Role of Autophagy in regulation of Spleen Immunology. Autophagic response in immune modulation of splenic dendritic cell and macrophages in malarial infection.