Aquaporins modulate water homeostasis in microscopic colitis

The purpose of this project is to link dysregulation of AQP water channels to the water loss and diarrhoea observed in microscopic colitis.  

Microscopic colitis (MC) is a chronic inflammatory bowel disease (IBD) that causes watery diarrhoea, abdominal pain, fatigue, weight loss, and lasting tissue damage.

Its pathophysiology remains largely unknown, and thus treatment options are often limited to non-specific, anti-inflammatory corticosteroid drugs.

Aquaporin (AQP) water channels are cell surface proteins that provide selective and rapid transport of water. Epithelial cells in the colon are responsible for water resorption from the bowel and thus the formation of feces. Therefore, defective water transport may cause diarrhoea in MC; however, the disease-specific AQP profile has not been investigated to date.

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