Jan Ernerudh

Professor Emeritus

Professor of Clinical Immunology at Linköping University, Chief Physician at Clinical Immunology and Transfusion Medicine, Diagnostic Center, Linköping University Hospital.

Publications

Selected references 2014-2021

Raffetseder J, Lindau R, van der Veen S, Berg G, Larsson M, Ernerudh J.
Mucosal-associated invariant T (MAIT) cells balance the requirements for immune tolerance and anti-microbial defense during pregnancy.
Frontiers Immunol, accepted for publication.
Papapavlou G, Hellberg S, Raffetseder J, Brynhildsen J, Gustafsson M, Jenmalm MC, Ernerudh J.
Differential effects of estradiol and progesterone on human T cell activation in vitro.
Eur J Immunol, accepted for publication.
Badam TV, Hellberg S, Mehta RB, Lechner-Scott J, Lea RA, Tost J, Mariette X, Svensson-Arvelund J, Nestor CE, Benson M, Berg G, Jenmalm MC, Gustafsson M*, Ernerudh J*. *Contributed equally
CD4+ T-cell DNA methylation changes during pregnancy significantly correlate with disease-associated methylation changes in autoimmune diseases.
Epigenetics, accepted for publication.
Hellberg S, Raffetseder J, Rundquist O, Magnusson R, Papapavlou G, Jenmalm MC, Ernerudh J*, Gustafsson M*. *Contributed equally
Progesterone dampens immune responses in in vitro activated CD4+ T cells and affects genes associated with autoimmune diseases that improve during pregnancy.
Front Immunol. 2021;12:672168.
Lindau R, Vondra S, Spreckels J, Solders M, Svensson-Arvelund J, Berg G, Pollheimer J, Kaipe H, Jenmalm MC, Ernerudh J.
Decidual stromal cells support tolerance at the human fetal-maternal interface by inducing regulatory M2 macrophages and regulatory T-cells.
J Reprod Immunol 2021;146:103330.
Gawel DR, Serra-Musach J, Lilja S,….Ernerudh J, et al.
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases.
Genome Med. 2019;11:47
Hellberg S, Mehta RB, Forsberg A, Berg G, Brynhildsen J, Winqvist O, Jenmalm MC, Ernerudh J.
Maintained thymic output of conventional and regulatory T cells during human pregnancy.
J Allergy Clin Immunol. 2019;143:771
Lindau R, Mehta RB, Lash GE, Papapavlou G, Boij R, Berg G, Jenmalm MC, Ernerudh J, Svensson-Arvelund J.
Interleukin-34 is present at the fetal-maternal interface and induces immunoregulatory macrophages of a decidual phenotype in vitro.
Hum Reprod, 2018:33.
Bruno V, Svensson-Arvelund J, Rubér M, Berg G, Piccione E, Jenmalm MC, Ernerudh J.
Effects of low molecular weight heparin on the polarization and cytokine profile of macrophages and T helper cells in vitro.
Sci Rep, 2018:8.
Håkansson I, Tisell A, Cassel P, Blennow K, Zetterberg H, Lundberg P, Dahle C, Vrethem M, Ernerudh J.
Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis.
J Neuroinflammation, 2018:18
Håkansson I, Tisell A, Cassel P, Blennow K, Zetterberg H, Lundberg P, Dahle C, Vrethem M, Ernerudh J.
Neurofilament light chain in cerebrospinal fluid and prediction of disease activity in clinically isolated syndrome and relapsing remitting multiple sclerosis.
Eur j Neurol, 2017:24.
Hellberg, S., D. Eklund, D. Gawel, M. Kopsén, H. Zhang, C.E. Nestor, I. Kockum, T. Olsson, M. Vrethem, I. Håkansson, M. Benson, M.C. Jenmalm, M. Gustafsson, J. Ernerudh.
Dynamic response genes in CD4+ T cells reveals a protein network that accurately classifies disease activity in multiple sclerosis.
Cell Reports, 2016:16.
Svensson-Arvelund, J., R.B. Mehta, R. Lindau, E. Mirrasekhian, H. Rodriguez-Martinez, G. Berg, G.E. Lash, M.C. Jenmalm, and J. Ernerudh.
The human fetal placenta promotes tolerance against the semiallogeneic foetus by inducing regulatory T cells and homeostatic M2 macrophages.
J Immunol, 2015:194.
Gustafsson M., D. R. Gawel, L. Alfredsson, S. Baranzini, J. Bjorkander, R. Blomgran, S. Hellberg, D. Eklund, J. Ernerudh, I. Kockum, A. Konstantinell, R. Lahesmaa, A. Lentini, H. R. Liljenstrom, L. Mattson, A. Matussek, J. Mellergard, M. Mendez, T. Olsson, M. A. Pujana, O. Rasool, J. Serra-Musach, M. Stenmarker, S. Tripathi, M. Viitala, H. Wang, H. Zhang, C. E. Nestor, M. Benson.
A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases.
Science translational medicine 2015:7.
Gustafsson M, Edström M, Gawel D, Nestor CE, Wang H, Zhang H, Barrenäs F, Tojo J, Kockum I, Olsson T, Serra-Musach J, Bonifaci N, Pujana MA, Ernerudh J, Benson M.
Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment.
Genome Med. 2014:6.

Latest publications in LiU DiVA

2023

Research

Research description

The general purpose of our research is to reveal mechanisms of immune tolerance in pregnancy and how failure of tolerance mechanisms can lead to pregnancy complications. In addition, inflammatory diseases like multiple sclerosis transiently improve and worsen during and after pregnancy, respectively, and therefore, immune regulation during pregnancy is used as a model to understand mechanisms of improvement and worsening of MS.

Read more about our reseearch via the links.

Reproduktionsimmunologi, Jan Ernerudh med baby

Reproduction and Neuro Immunology

The general purpose of our research is to reveal mechanisms of immune tolerance in pregnancy and how failure of tolerance mechanisms can lead to pregnancy complications.

Medical Inflammation and Infection Center (MIIC)

Medical Inflammation and Infection Center (MIIC) research focus is on infections and inflammatory conditions, which are major concerns for human health.

News

a coarse brush is applied to the back of the hand

SEK 64 million to research in medicine and health

Fourteen researchers at LiU have received grants totalling more than SEK 64 million. This is the result when the Swedish Research Council has awarded nearly SEK 1.1 billion in research grants for the medical and health sciences.

A major role for a small organ during pregnancy

The immune system of a pregnant woman is altered during pregnancy, but not in the way previously believed. A study from LiU shows that the thymus plays an important role in the immune response during a normal pregnancy.

Placenta protects foetus from mother’s immune system

The immune system of the mother-to-be is a deadly threat to the foetus, and must therefore be weakened during pregnancy. New research shows that this adjustment is controlled by the placenta.

Organisation

Teaser image for the division II at BKV.

Division of Inflammation and Infection (II)

The Division of Inflammation and Infection (II) includes clinical subject areas such as Immunology, Rheumatology, Pathology and Microbiology.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.