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Markus Karlsson

My aim is to develop methods for diagnosis of liver diseases

Early characterization of function, fibrosis and inflammation in the liver

The aim of my research is to develop methods for characterization of liver fibrosis, inflammation and function using magnetic resonance imaging (MRI). I’m mainly working with two different technics: MR-elastography (MRE) and dynamic contrast enhanced MRI (DCE‑MRI) together with systems biology.

MRE is currently being used for characterization of liver fibrosis. The goal of my work is to show that by using 3D multi frequency MRE it is possible to characterize not only liver fibrosis, but also liver inflammation.

The second part of my research, concerning DCE‑MRI, is aimed at determining regional liver function. DCE‑MRI is performed with the liver specific contrast agent Gd‑EOB‑DTPA (Primovist®). From the resulting images, quantitative measures of contrast agent concentration can be derived. These concentrations are then used to estimate kinetic parameters, of the uptake of contrast agent, in a mechanistic mathematical model. Our hope is some of these kinetic parameters will be used as biomarkers for liver function.



Markus Karlsson, Christian Simonsson, Nils Dahlström, Gunnar Cedersund, Peter Lundberg (2023) Mathematical models for biomarker calculation of drug-induced liver injury in humans and experimental models based on gadoxetate enhanced magnetic resonance imaging PLOS ONE, Vol. 18, Article e0279168 Continue to DOI


Carl Edin, Mattias Ekstedt, Tobias Scheffel, Markus Karlsson, Eva Swahn, Carl Johan Östgren, Jan Engvall, Tino Ebbers, Olof Dahlqvist Leinhard, Peter Lundberg, Carl-Johan Carlhäll (2022) Ectopic fat is associated with cardiac remodeling - A comprehensive assessment of regional fat depots in type 2 diabetes using multi-parametric MRI. Frontiers in Cardiovascular Medicine, Vol. 9, Article 813427 Continue to DOI


Mikael F Forsgren, Patrik Nasr, Markus Karlsson, Nils Dahlström, Bengt Norén, Simone Ignatova, Ralph Sinkus, Gunnar Cedersund, Olof Dahlqvist Leinhard, Mattias Ekstedt, Stergios Kechagias, Peter Lundberg (2020) Biomarkers of liver fibrosis: prospective comparison of multimodal magnetic resonance, serum algorithms and transient elastography. Scandinavian Journal of Gastroenterology, Vol. 55, p. 848-859 Continue to DOI