I aim to perform this by expanding on my supervisor's, Mika Gustavsson's, previous work where he created a gene regulatory network for T-cell diffrentiation. To this network I intend to add proteomics and RNA-sequencing data from early T-cell diffrentiation to future enhance the network.
T-lymphocytes are the generals of the immune system coordinating the other immune cells to properly fight infections. As T-lymphocytes are very important to the proper function of the immune system they, when malfunctioning, very commonly cause autoimmune diseases. This makes T-lymphocytes lucrative drug targets. Drug development is however a very expensive and time consuming process. By expanding the knowledge behind the signaling network of these cells we aim to create a model to predict their response to drugs by the use of computer simulations.
Olof Rundquist
PhD student
