The aim of my research is to expand the knowledge of the signaling networks within human T-lymphocytes.

I aim to perform this by expanding on my supervisor's, Mika Gustavsson's, previous work where he created a gene regulatory network for T-cell diffrentiation. To this network I intend to add proteomics and RNA-sequencing data from early T-cell diffrentiation to future enhance the network.

T-lymphocytes are the generals of the immune system coordinating the other immune cells to properly fight infections. As T-lymphocytes are very important to the proper function of the immune system they, when malfunctioning, very commonly cause autoimmune diseases. This makes T-lymphocytes lucrative drug targets. Drug development is however a very expensive and time consuming process. By expanding the knowledge behind the signaling network of these cells we aim to create a model to predict their response to drugs by the use of computer simulations.

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Higher education degrees

  • 2013 Degree of Bachelor of Chemical Biology, Linköping University, Linköping, Sweden

Bachelor’s Degree Project: ‘Do variations in the promotor of VRN1 affect frost resistance in wheat from Northern Europe?’, Linköping University, Linköping, Sweden
Supervisor: Jenny Hagenblad

  • 2015 Degree of Master of Experimental and Medical Biosciences, Linköping University, Linköping, Sweden

First year scientific project (15 credits): ‘BMP2 and STK32A expression is linked to variation in comb size’, Linköping University, Linköping, Sweden
Supervisor: Dominic Wright

Master thesis (30 credits): ‘TET-regulation of DNA-Methylation and T-cell differentiation: The influence of Vitamin C’, Linköping University, Linköping, Sweden
Supervisor: Colm Nestor

 

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