The Mayo Affective Neuroscience (MAN) Lab
We are interested in how humans process and react to emotional information and stressful situations, and how dysregulation of these processes contribute to various psychiatric disorders. We approach these questions using a combination of psychophysiology, neuroimaging, behavior, and pharmacology in healthy and clinical populations.
We are particularly interested in the role of the endocannabinoid system, a neuromodulatory system implicated in affect and stress reactivity. In healthy humans, we are exploring how external factors (e.g. stress, drugs of abuse) influence the endocannabinoid system. In clinical populations, we are interested in how dysregulation of the endocannabinoid system contributes to impairments in stress responding and emotional reactivity.
Our long term goal is to determine whether this neurotransmitter system may serve as a novel target in the treatment of stress- and affect-related psychiatric disorders such as post-traumatic stress disorder (PTSD).