LiU Cancer Seminar Series 2022
LiU Cancer is an initiative from several groups at Linköping University having the common goal to understand and defeat cancer. LiU Cancer organizes weekly seminars where both LiU researchers and scientists from other universities are involved.
For the spring of 2022, there is a line of talks given by outstanding speakers! Everyone from LiU is more than welcome to participate.
There is now a preliminary program available with both internal and external speakers for LiU Cancer's seminar series for the spring of 2022. You will find more information and meeting links below.
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Abstract - Seminar on June 14th
Nucleases as Molecular Targets for Cancer Diagnosis
Alien Balian and Frank J. Hernandez
Early cancer diagnosis is a crucial element to improved treatment options and survival. Great research efforts have been made in the search for better performing cancer diagnostic biomarkers. However, the quest continues as novel biomarkers with high accuracy for an early diagnosis remain an unmet clinical need. Nucleases, which are enzymes capable of cleaving nucleic acids, have been long considered as potential cancer biomarkers. The diversity of nucleases in structure, function and subcellular localization, their implication in pivotal biological events together with their unique feature of catalytic activity led the enthusiasm towards investigating the role of nucleases as promising cancer biomarkers.
However, the most essential feature of these proteins, which is their enzymatic activity, has not been fully exploited. Herein, we discuss nucleases interrogated as cancer biomarkers, providing a glimpse of their physiological roles. Moreover, we highlight harnessing the enzymatic activity of cancer-associated nucleases as a novel diagnostic biomarker using nucleic acid probes as substrates.