Ion channels are fascinating proteins that generate and sense electrical signals in the cell. In the Pantazis laboratory, we employ cutting-edge experimental and computational approaches to understand how the intricate structure of ion channels relates to their function.
We also study how protein partners and signaling molecules regulate ion channel activity, altering their structure and bestowing new functional properties. Finally, we are striving to understand, at the molecular level, life-threatening diseases that arise from ion channel dysfunction (channelopathies). We use techniques such as electrophysiology, fluorescence spectroscopy, confocal microscopy, flow cytometry, and computer simulation—in addition, we develop new methods to tackle experimental challenges in physiology.