Pantazis Laboratory of Cellular Excitability - PaLaCE

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Our research

Ion channel function, structure and regulation in health and disease. Ion channels are fascinating proteins that generate and sense electrical signals in the cell.

In the Pantazis Laboratory of Cellular Excitability - PaLaCE, we employ cutting-edge experimental and computational approaches to understand how the intricate structure of ion channels relates to their function.

We also study how protein partners and signaling molecules regulate ion channel activity, altering their structure and bestowing new functional properties. Finally, we are striving to understand, at the molecular level, life-threatening diseases that arise from ion channel dysfunction (channelopathies). We use techniques such as electrophysiology, fluorescence spectroscopy, confocal microscopy, flow cytometry, and computer simulation—in addition, we develop new methods to tackle experimental challenges in physiology.

Click play to see how the voltage-clamp fluorometry technique “illuminates” a voltage-gated calcium channel complex (structure #7MIY by the Yan lab).

Research group

News and Twitter

Lab notices

March 2023

πŸ† Award: Michelle Nilsson’s article received the “Best Scientific Paper Award” by the LiU Medical Faculty Student Association.

πŸ™‚ People: Panagiota “Penny” Gkotsi (Univ. of Patras School of Medicine) is joining us as an Erasmus+ exchange student.

πŸ™‚ People: Serena Pozzi is now officially a PhD student! She will study how a new variant of the cardiac sodium channel causes an unexpected, familial, and sometimes lethal type of cardiac arrhythmia.

February 2023

πŸŒŽπŸ† Conference & Award: Biophysical Society annual meeting, San Diego, CA. Michelle gave a platform presentation; Serena, Catherine and Antonios presented posters, and there was one more poster from our collaboration with the Olcese lab, UCLA. Antonios also co-chaired the Voltage-gated sodium and calcium channel platforms session. Catherine was given a travel award by the Biophysical Society!
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Lab Alumni

Research area