Pantazis Laboratory of Cellular Excitability - PaLaCE

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Our research

Ion channel function, structure and regulation in health and disease. Ion channels are fascinating proteins that generate and sense electrical signals in the cell.

In the Pantazis Laboratory of Cellular Excitability - PaLaCE, we employ cutting-edge experimental and computational approaches to understand how the intricate structure of ion channels relates to their function.

We also study how protein partners and signaling molecules regulate ion channel activity, altering their structure and bestowing new functional properties. Finally, we are striving to understand, at the molecular level, life-threatening diseases that arise from ion channel dysfunction (channelopathies). We use techniques such as electrophysiology, fluorescence spectroscopy, confocal microscopy, flow cytometry, and computer simulation—in addition, we develop new methods to tackle experimental challenges in physiology.

Click play to see how the voltage-clamp fluorometry technique “illuminates” a voltage-gated calcium channel complex (structure #7MIY by the Yan lab).

Research group


Lab notices

November 2023

🏆 Award: Antonios received the Swedish Fernström Prize!

October 2023

📰 Publication: Mínguez-Viñas T, Prakash V, Wang K, Lindström SH, Pozzi S, Scott SA, Spiteri E, Stevenson DA, Ashley EA, Gunnarsson C, Pantazis A. Two epilepsy-associated variants in KCNA2 (KV1.2) at position H310 oppositely affect channel functional expression. J Physiol. 2023 Oct 26. doi: 10.1113/JP285052. PMID: 37883018.

June 2023

💰 Funding: The Swedish Brain Foundation (Hjärnfonden) funded our application FO2023-0025!

March 2023

🏆 Award: Michelle Nilsson’s article received the “Best Scientific Paper Award” by the LiU Medical Faculty Student Association.

🙂 People: Panagiota “Penny” Gkotsi (Univ. of Patras School of Medicine) is joining us as an Erasmus+ exchange student.

🙂 People: Serena Pozzi is now officially a PhD student! She will study how a new variant of the cardiac sodium channel causes an unexpected, familial, and sometimes lethal type of cardiac arrhythmia.

February 2023

🌎🏆 Conference & Award: Biophysical Society annual meeting, San Diego, CA. Michelle gave a platform presentation; Serena, Catherine and Antonios presented posters, and there was one more poster from our collaboration with the Olcese lab, UCLA. Antonios also co-chaired the Voltage-gated sodium and calcium channel platforms session. Catherine was given a travel award by the Biophysical Society!
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News articles from LiU

External news articles



Teresa Mínguez‐Viñas, Varsha Prakash, Kaiqian Wang, Sarah Lindström, Serena Pozzi, Stuart A. Scott, Elizabeth Spiteri, David A. Stevenson, Euan A. Ashley, Cecilia Gunnarsson, Antonios Pantazis (2023) Two epilepsy‐associated variants in KCNA2 (KV1.2) at position H310 oppositely affect channel functional expression Journal of Physiology Continue to DOI


Michelle Nilsson, Sarah H Lindström, Maki Kaneko, Kaiqian Wang, Teresa Minguez-Viñas, Marina Angelini, Federica Steccanella, Deborah Holder, Michela Ottolia, Riccardo Olcese, Antonios Pantazis (2022) An epilepsy-associated KV1.2 charge-transfer-center mutation impairs KV1.2 and KV1.4 trafficking Proceedings of the National Academy of Sciences of the United States of America, Vol. 119 Continue to DOI


Marina Angelini, Arash Pezhouman, Nicoletta Savalli, Marvin G. Chang, Federica Steccanella, Kyle Scranton, Guillaume Calmettes, Michela Ottolia, Antonios Pantazis, Hrayr S. Karagueuzian, James N. Weiss, Riccardo Olcese (2021) Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current The Journal of General Physiology, Vol. 153, Article e202012584 Continue to DOI


Antonios Pantazis, Maki Kaneko, Marina Angelini, Federica Steccanella, Annie M. Westerlund, Sarah Lindström, Michelle Nilsson, Lucie Delemotte, Sulagna C. Saitta, Riccardo Olcese (2020) Tracking the motion of the K(V)1.2 voltage sensor reveals the molecular perturbations caused by ade novomutation in a case of epilepsy Journal of Physiology, Vol. 598, p. 5245-5269 Continue to DOI


Antonios Pantazis, Riccardo Olcese (2019) Cut-Open Oocyte Voltage-Clamp Technique Encyclopedia of Biophysics Continue to DOI
Sharmila Venugopal, Soju Seki, David H. Terman, Antonios Pantazis, Riccardo Olcese, Martina Wiedau-Pazos, Scott H. Chandler (2019) Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons. PloS Computational Biology, Vol. 15, Article e1007154 Continue to DOI
Soju Seki, Toru Yamamoto, Kiara Quinn, Igor Spigelman, Antonios Pantazis, Riccardo Olcese, Martina Wiedau-Pazos, Scott H. Chandler, Sharmila Venugopal (2019) Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1(G93A) Mouse Model for ALS Journal of Neuroscience, Vol. 39, p. 8798-8815 Continue to DOI


Antonios Pantazis, Karin Westerberg, Thorsten Althoff, Jeff Abramson, Riccardo Olcese (2018) Harnessing photoinduced electron transfer to optically determine protein sub-nanoscale atomic distances Nature Communications, Vol. 9, Article 4738 Continue to DOI

Lab Alumni

Research area