LiU Cancers seminarieserie 2022
LiU Cancer är ett initiativ från flera grupper vid Linköpings universitet med det gemensamma målet att förstå och besegra cancer. LiU Cancer anordnar veckovisa seminarier där både LiU-forskare och forskare från andra universitet är involverade.
För våren 2022 finns en rad föredrag som hålls av enastående talare! Alla från LiU är mer än välkomna att delta.
Nu finns ett sammanställt program med både interna och externa talare för LiU Cancers seminarieserie för våren 2022. Ta del av mer information och möteslänkar här nedan.
Kommande seminarier Visa/dölj innehåll
Abstrakt inför seminarium den 14 juni
Nucleases as Molecular Targets for Cancer Diagnosis
Alien Balian och Frank J. Hernandez
Early cancer diagnosis is a crucial element to improved treatment options and survival. Great research efforts have been made in the search for better performing cancer diagnostic biomarkers. However, the quest continues as novel biomarkers with high accuracy for an early diagnosis remain an unmet clinical need. Nucleases, which are enzymes capable of cleaving nucleic acids, have been long considered as potential cancer biomarkers. The diversity of nucleases in structure, function and subcellular localization, their implication in pivotal biological events together with their unique feature of catalytic activity led the enthusiasm towards investigating the role of nucleases as promising cancer biomarkers.
However, the most essential feature of these proteins, which is their enzymatic activity, has not been fully exploited. Herein, we discuss nucleases interrogated as cancer biomarkers, providing a glimpse of their physiological roles. Moreover, we highlight harnessing the enzymatic activity of cancer-associated nucleases as a novel diagnostic biomarker using nucleic acid probes as substrates.
