Oliver Gimm received his surgical training in Germany where he became interested in endocrine surgery. His research training was intensified during a 3-year stay in the U.S.A. where he became familiar with molecular genetics.
Since 2007, Oliver Gimm is working at the University Hospital in Linköping. In 2010, he became University affiliated. His research is both pre-clinically and clinically oriented. Currently, Oliver Gimm’s research is mainly focusing on the following topics.
Endocrine tumors (clinical and preclinical studies)
Molecular genetic analysis of endocrine tumors (thyroid, parathyroid, adrenal, neuroendocrine): pathogenesis and development of metastases
The aim of these projects are to:
- Identify chromosomal regions with loss or gain to then further look for genes that affect tumor development and / or metastasis.
Graphic illustration of a DNA microarray analysis showing typical regions with gains and loss in a pheochromocytoma (catecholamine producing adrenal tumor).
Click on the images to see in a larger view.
- Study and compare gene/protein expression between normal tissue, benign tumors, malignant tumors and metastases. In this way, we want to find specific biological properties and / or processes that may be important for tumor pathogenesis and development of metastases.
Picture 1: Expression of the neurofibromatosis
gene NF1: loss is associated with lower mRNA expression in pheochromcoytomas.
Picture 2: Immunostaining for SDHB: a pheochromocytoma (top) stains negative in comparison to a positive control (bottom) which is highly suggestive for a mutation in SDHB, a tumor often associated with malignant behavior
- Study the clinical, diagnostic and prognostic significance of various gene / protein expression and relate them to known clinical and pathological markers and prognostic factors.
Clinical correlation: pheochromocytomas with somatic NF1 mutation produce higher levels of catecholamines
- Evaluate gene/protein expression in relation to the treatment of endocrine tumors.
Localization of small endocrine tumors such as ectopic parathyroid glands
The aim of these projects are to
- Improve our ability to localize small endocrine tumors (e.g., ectopic parathyroid glands) either by modifying existing techniques or by developing new techniques.
Picture 1: Superselective venous sampling of parathyroid hormone (PTH) levels helping regionalizing a parathyroid adenoma responsible for hypercalcemia
Picture 2: Dual-energy CT localizing an ectopic parathyroid adenoma missed by other imaging techniques
Name: Oliver Gimm
Position: Professor of Surgery
Department of Clinical and Experimental Medicine
Division of Clinical Sciences, Surgery
SE-581 85 Linköping
Last updated: Mon Jan 25 10:55:33 CET 2016