Protein Chemistry, 12 credits (NKED15)

Proteinkemi, 12 hp

Main field of study

Chemical Biology Chemistry

Level

Second cycle

Course type

Programme course

Examiner

Lars-Göran Mårtensson

Director of studies or equivalent

Magdalena Svensson

Available for exchange students

Yes
Course offered for Semester Period Timetable module Language Campus VOF
6MKOS Organic Synthesis and Medicinal Chemistry, Master's Programme 2 (Spring 2018) 1 1+2 English Linköping o
6MPRO Protein Science, Master's Programme (External) 2 (Spring 2018) 1 1+2 English Linköping o
6KBIO Biology 6 (Spring 2018) 1 1+2 English Linköping v
6KKEB Chemical Biology 6 (Spring 2018) 1 1+2 English Linköping o
6KKEM Chemistry 6 (Spring 2018) 1 1+2 English Linköping v

Main field of study

Chemical Biology, Chemistry

Course level

Second cycle

Advancement level

A1X

Course offered for

  • Organic Synthesis and Medicinal Chemistry, Master's Programme
  • Protein Science, Master's Programme
  • Biology
  • Chemical Biology
  • Chemistry

Entry requirements

Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshold requirements for progression within the programme, or corresponding.

Prerequisites

General Chemistry, Organic Chemistry, Biochemistry

Intended learning outcomes

The objectives of the course is to provide comprehensive knowledge in the following areas:
Protein chemistry, protein engineering, structure and function relationships, physicochemical properties of proteins and methodologies for characterization of proteins. After studies well learned the student will have proficiency to:

  • Identify structure motifs and from this draw conclusions regarding the structure and function of proteins.
  • Search for information from various data bases to visualize protein structures and compare amino acid sequences.
  • Draw conclusions about protein dynamics, structure and function from detailed chemical and physical properties.
  • Comprehend the fundamental mechanisms of protein folding and to have a deeper understanding of the factors determining the stability of a protein.
  • Define scientific problems within this area that can be tackled and solved by experiments.
  • Adopt a reflecting, scientific attitude to the theories and obtained experimental results.
  • Work in a group in a project-oriented way in the laboratory.

Course content

Theoretical part: Different structure motifs of proteins. Multifunctional enzymes, membrane proteins, prediction of protein structures. Studies of physico-chemical properties of proteins and methodology for studies of these properties: Chemical characteristics of polypeptides, protein engineering, physical interactions determining the properties of proteins, role of hydrophobic interaction, conformation flexibility, protein stability, mechanisms of protein folding, interaction with other proteins, enzyme catalysis.
Project part: Studies of physico-chemical properties of proteins and methodology for studies of these properties. Methodology used for these studies is biophysical methods such as fluorescence spectroscopy, circular dichroism spectroscopy (CD) and calorimetry (ITC). Sequence analysis and structure modeling are used for result analysis.

Teaching and working methods

The course is divided into a theoretical and a project part in order to give opportunity to deeper and more intergrated studies.The theory is presented and treated at lectures and lessons. Three-dimensional structures of proteins and computer simulations are performed in smaller groups. During the project part the students work with genetically mutated proteins cloned in bacteria. The origin of the mutated protein can be proteins that have been mutated by the students in an earlier course in gene technology or can be provided by the research group. The protein variants are characterized. Starting with a project plan the students perform the detail plans for the experimental work. This planning process will proceed interactively through meetings between the groups and the teacher/lab.assistant. The students should then independently evaluate their experimental results. The results of the experimental work is presented in a written report in enlish.

Examination

TEN1Written examinationU, 3, 4, 56 credits
PRA1Project workU, G6 credits
The exercises of the written examination and the test elucidate how well the student perform the the demands of the course.

Grades

Four-grade scale, LiU, U, 3, 4, 5

Department

Institutionen för fysik, kemi och biologi

Director of Studies or equivalent

Magdalena Svensson

Examiner

Lars-Göran Mårtensson

Education components

Preliminary scheduled hours: 55 h
Recommended self-study hours: 265 h

Course literature

David Whitford, Proteins Structure and Function, Wiley. Projektbeskrivning från institutionen.
David Whitford, Proteins Structure and Function, Wiley. Projektbeskrivning från institutionen.
TEN1 Written examination U, 3, 4, 5 6 credits
PRA1 Project work U, G 6 credits
The exercises of the written examination and the test elucidate how well the student perform the the demands of the course.

Course syllabus

A syllabus has been established for each course. The syllabus specifies the aim and contents of the course, and the prior knowledge that a student must have in order to be able to benefit from the course.

Timetabling

Courses are timetabled after a decision has been made for this course concerning its assignment to a timetable module. A central timetable is not drawn up for courses with fewer than five participants. Most project courses do not have a central timetable.

Interrupting a course

The vice-chancellor’s decision concerning regulations for registration, deregistration and reporting results (Dnr LiU-2015-01241) states that interruptions in study are to be recorded in Ladok. Thus, all students who do not participate in a course for which they have registered must record the interruption, such that the registration on the course can be removed. Deregistration from a course is carried out using a web-based form: www.lith.liu.se/for-studenter/kurskomplettering?l=sv. 

Cancelled courses

Courses with few participants (fewer than 10) may be cancelled or organised in a manner that differs from that stated in the course syllabus. The board of studies is to deliberate and decide whether a course is to be cancelled or changed from the course syllabus. 

Regulations relating to examinations and examiners 

Details are given in a decision in the university’s rule book: http://styrdokument.liu.se/Regelsamling/VisaBeslut/622678.

Forms of examination

Examination

Written and oral examinations are held at least three times a year: once immediately after the end of the course, once in August, and once (usually) in one of the re-examination periods. Examinations held at other times are to follow a decision of the board of studies.

Principles for examination scheduling for courses that follow the study periods:

  • courses given in VT1 are examined for the first time in March, with re-examination in June and August
  • courses given in VT2 are examined for the first time in May, with re-examination in August and October
  • courses given in HT1 are examined for the first time in October, with re-examination in January and August
  • courses given in HT2 are examined for the first time in January, with re-examination at Easter and in August.

The examination schedule is based on the structure of timetable modules, but there may be deviations from this, mainly in the case of courses that are studied and examined for several programmes and in lower grades (i.e. 1 and 2). 

  • Examinations for courses that the board of studies has decided are to be held in alternate years are held only three times during the year in which the course is given.
  • Examinations for courses that are cancelled or rescheduled such that they are not given in one or several years are held three times during the year that immediately follows the course, with examination scheduling that corresponds to the scheduling that was in force before the course was cancelled or rescheduled.
  • If teaching is no longer given for a course, three examination occurrences are held during the immediately subsequent year, while examinations are at the same time held for any replacement course that is given, or alternatively in association with other re-examination opportunities. Furthermore, an examination is held on one further occasion during the next subsequent year, unless the board of studies determines otherwise.
  • If a course is given during several periods of the year (for programmes, or on different occasions for different programmes) the board or boards of studies determine together the scheduling and frequency of re-examination occasions.

Registration for examination

In order to take an examination, a student must register in advance at the Student Portal during the registration period, which opens 30 days before the date of the examination and closes 10 days before it. Candidates are informed of the location of the examination by email, four days in advance. Students who have not registered for an examination run the risk of being refused admittance to the examination, if space is not available.

Symbols used in the examination registration system:

  ** denotes that the examination is being given for the penultimate time.

  * denotes that the examination is being given for the last time.

Code of conduct for students during examinations

Details are given in a decision in the university’s rule book: http://styrdokument.liu.se/Regelsamling/VisaBeslut/622682.

Retakes for higher grade

Students at the Institute of Technology at LiU have the right to retake written examinations and computer-based examinations in an attempt to achieve a higher grade. This is valid for all examination components with code “TEN” and "DAT". The same right may not be exercised for other examination components, unless otherwise specified in the course syllabus.

Retakes of other forms of examination

Regulations concerning retakes of other forms of examination than written examinations and computer-based examinations are given in the LiU regulations for examinations and examiners, http://styrdokument.liu.se/Regelsamling/VisaBeslut/622678.

Plagiarism

For examinations that involve the writing of reports, in cases in which it can be assumed that the student has had access to other sources (such as during project work, writing essays, etc.), the material submitted must be prepared in accordance with principles for acceptable practice when referring to sources (references or quotations for which the source is specified) when the text, images, ideas, data, etc. of other people are used. It is also to be made clear whether the author has reused his or her own text, images, ideas, data, etc. from previous examinations.

A failure to specify such sources may be regarded as attempted deception during examination.

Attempts to cheat

In the event of a suspected attempt by a student to cheat during an examination, or when study performance is to be assessed as specified in Chapter 10 of the Higher Education Ordinance, the examiner is to report this to the disciplinary board of the university. Possible consequences for the student are suspension from study and a formal warning. More information is available at https://www.student.liu.se/studenttjanster/lagar-regler-rattigheter?l=sv.

Grades

The grades that are preferably to be used are Fail (U), Pass (3), Pass not without distinction (4) and Pass with distinction (5). Courses under the auspices of the faculty board of the Faculty of Science and Engineering (Institute of Technology) are to be given special attention in this regard.

  1. Grades U, 3, 4, 5 are to be awarded for courses that have written examinations.
  2. Grades Fail (U) and Pass (G) may be awarded for courses with a large degree of practical components such as laboratory work, project work and group work.

Examination components

  1. Grades U, 3, 4, 5 are to be awarded for written examinations (TEN).
  2. Grades Fail (U) and Pass (G) are to be used for undergraduate projects and other independent work.
  3. Examination components for which the grades Fail (U) and Pass (G) may be awarded are laboratory work (LAB), project work (PRA), preparatory written examination (KTR), oral examination (MUN), computer-based examination (DAT), home assignment (HEM), and assignment (UPG).
  4. Students receive grades either Fail (U) or Pass (G) for other examination components in which the examination criteria are satisfied principally through active attendance such as other examination (ANN), tutorial group (BAS) or examination item (MOM).

The examination results for a student are reported at the relevant department.

Regulations (apply to LiU in its entirety)

The university is a government agency whose operations are regulated by legislation and ordinances, which include the Higher Education Act and the Higher Education Ordinance. In addition to legislation and ordinances, operations are subject to several policy documents. The Linköping University rule book collects currently valid decisions of a regulatory nature taken by the university board, the vice-chancellor and faculty/department boards.

LiU’s rule book for education at first-cycle and second-cycle levels is available at http://styrdokument.liu.se/Regelsamling/Innehall/Utbildning_pa_grund-_och_avancerad_niva. 

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