Models in System Biology, 2 credits (TBMT19)

Systembiologisk modellering, 2 hp

Main field of study



First cycle

Course type

Programme course


Gunnar Cedersund

Director of studies or equivalent

Marcus Larsson
Course offered for Semester Period Timetable module Language Campus VOF
6CTBI Engineering Biology, M Sc in Engineering 6 (Spring 2017) 1 3 English Linköping o

Main field of study


Course level

First cycle

Advancement level


Course offered for

  • Engineering Biology, M Sc in Engineering

Entry requirements

Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshold requirements for progression within the programme, or corresponding.


Basics courses in Chemistry, Biology and Mathematics

Intended learning outcomes

This course will provide experience in mathematical modeling of biological systems. After completing this course, the participant shall be able to:

  • explain why mathematical modeling is a tool in biological experimentation; explain some of the common mistakes
  • construct a mathematical model of a class of biological systems
  • analyzing, structuring and simulating mathematical models based on differential equations
  • use methods for structured modeling in systems biology
  • adapt mathematical models to measured data
  • validate mathematical models to measured data; basic statistical tests
  • use modern computerized tools for mathematical modeling in systems biology
  • apply and integrate this with knowledge from previous courses


Course content

Lectures, laboratory work covers:

  • Systems biology: what it is, methods, issues and opportunities.
  • Mathematical modeling. Types of models and their properties.
  • Software for mathematical modeling and simulation in systems biology.
  • System Identification: adaptation of mathematical models to experimental data.
  • Validation and use of mathematical models. Troubleshooting and uncertainty analysis


Teaching and working methods

The course consists of lectures and a large laboratory assignment and voluntary pre-assignments. The course is examined by two minor tests together with oral discussions of the laboratory work.
The course runs for the first three weeks during the spring semester.


UPG1TestsU, G2 credits

Grades are given as ’Fail’ or *Pass’.


Two-grade scale, U, G


Institutionen för medicinsk teknik

Director of Studies or equivalent

Marcus Larsson


Gunnar Cedersund

Education components

Preliminary scheduled hours: 18 h
Recommended self-study hours: 35 h

Course literature

Additional literature


Gunnar’s Crash Course in Systems Biology. Online-lectures.


Additional literature


Gunnar’s Crash Course in Systems Biology. Online-lectures.


UPG1 Tests U, G 2 credits

Grades are given as ’Fail’ or *Pass’.

Regulations (apply to LiU in its entirety)

The university is a government agency whose operations are regulated by legislation and ordinances, which include the Higher Education Act and the Higher Education Ordinance. In addition to legislation and ordinances, operations are subject to several policy documents. The Linköping University rule book collects currently valid decisions of a regulatory nature taken by the university board, the vice-chancellor and faculty/department boards.

LiU’s rule book for education at first-cycle and second-cycle levels is available at 

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