Biomolecular Disease Processes, 6 credits (TFKE48)

Biomolekylära sjukdomsprocesser, 6 hp

Main field of study

Chemical Biology Chemistry

Level

Second cycle

Course type

Programme course

Examiner

Peter Nilsson

Director of studies or equivalent

Magdalena Svensson

Available for exchange students

Yes
Course offered for Semester Period Timetable module Language Campus VOF
6MPRO Protein Science, Master's Programme (Internal) 1 (Autumn 2017) 2 1 Swedish/English Linköping o
6CKEB Chemical Biology, M Sc in Engineering (Protein Science and Technology) 7 (Autumn 2017) 2 1 Swedish/English Linköping v
6MPRO Protein Science, Master's programme (External) 3 (Autumn 2017) 2 1 Swedish/English Linköping o

Main field of study

Chemical Biology, Chemistry

Course level

Second cycle

Advancement level

A1X

Course offered for

  • Protein Science, Master's Programme
  • Chemical Biology, M Sc in Engineering
  • Protein Science, Master's programme

Entry requirements

Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshold requirements for progression within the programme, or corresponding.

Prerequisites

Protein chemistry. Three years of Chemistry / Chemical biology program or equivalent program

Intended learning outcomes

The course aims to provide knowledge of biomolecular processer of common degenerative diseases (Alzheimer´s disease, type II diabetes) and rare diseases (systemic and familial amyloidoses) which collectively are caused by misfolded protein molecules.After the course the student is able to:

  • explpain with deep insight of molecular processes concerning protein misfolding.
  • explain with deep insight how mutations influence protein conformational changes,
  • give avenues for therapeutic strategies against different diseases.

Course content

The course handles the background of a group of human diseases known as the amyloidoses or protein conformational diseases. The links between protein structure, the biophysical and chemical properties of proteins and the link from mutation to conformational change are studied in detail with a number of examples from human diseases.
Proteins studied in detail are: amyloid-beta (Alzheimer’s disease); prion protein (Creutzfeldt Jakob disease); BR12 (familial brittish and danish dementia); immunoglobulin (primary systemic amyloidosis); transthyretin (familial amyloidotic polyneuropathy); high density lipo proteins, amyloid-A (secondary amyloid-A amyloidosis), apoAII; gelsolin (Finnish familial amyloidosis); lysozyme (Inhereted non-neuropathic amyloidois); fibrinogen (inherited nephropathic amyloidosis); beta-2-microglobulin (dialysis related amyloidosis), cystatin-c (heritable cystatin-c amyloid angiopathy), islet amyloid poly peptide (type II diabetes).
The laboratory course contains experimental studies of amyloid fibrils.

Teaching and working methods

The course contains a number of lectures and a seminar series with active participation of the students. A minor laboratory course is also included.

Examination

TEN1Written examinationU, 3, 4, 55 credits
LAB1Laboratory workU, G1 credits

Grades

Four-grade scale, LiU, U, 3, 4, 5

Department

Institutionen för fysik, kemi och biologi

Director of Studies or equivalent

Magdalena Svensson

Examiner

Peter Nilsson

Education components

Preliminary scheduled hours: 54 h
Recommended self-study hours: 106 h

Course literature

Boken: ”Amyloid Proteins. The beta-sheet conformation and disease” vol. 2. Editor Jean D. Sipe (Whiley, VCH), samt vetenskapliga artiklar.
Boken: ”Amyloid Proteins. The beta-sheet conformation and disease” vol. 2. Editor Jean D. Sipe (Whiley, VCH), samt vetenskapliga artiklar.
TEN1 Written examination U, 3, 4, 5 5 credits
LAB1 Laboratory work U, G 1 credits

Regulations (apply to LiU in its entirety)

The university is a government agency whose operations are regulated by legislation and ordinances, which include the Higher Education Act and the Higher Education Ordinance. In addition to legislation and ordinances, operations are subject to several policy documents. The Linköping University rule book collects currently valid decisions of a regulatory nature taken by the university board, the vice-chancellor and faculty/department boards.

LiU’s rule book for education at first-cycle and second-cycle levels is available at http://styrdokument.liu.se/Regelsamling/Innehall/Utbildning_pa_grund-_och_avancerad_niva. 

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