By exploiting biorthogonal covalent crosslinking reactions and self-assembling peptides we are currently developing novel peptide-hybrid materials for applications in 3D cell culture, biomineralization, drug delivery and regenerative medicine. Furthermore, we also combine different fibrous polymer meshes with other functional components (e.g. electrically conducting- and antimicrobial polymers) to realise biomaterials for cardiac regeneration and advanced wound care applications.