Photo of Elena Di Martino

Elena Di Martino

Assistant Professor

Understanding how the neonatal brain develops and responds to injury is essential for tackling some of the most pressing long-term challenges.

About me

I earned my PhD in Neuroscience from Karolinska Institutet, where I investigated the neuroinflammatory mechanisms underlying neonatal hypoxic–ischemic brain injury. I subsequently pursued postdoctoral research at the University of California, San Francisco (UCSF), focusing on microglia–neuron interactions in neonatal stroke.

Over time, my research interests expanded to include the role of peripheral immune signaling in the developing brain. Since my appointment as an Assistant Professor at Linköping University and the establishment of the Experimental Pediatrics Lab with focus on Perinatal Neuroscience, my research has focused on understanding how brain injuries during the neonatal period influence brain development, with particular emphasis on the mechanisms through which innate immune cells communicate with and shape the neuroinflammatory response in the post-ischemic brain.

Publications

2026

Elena Di Martino, Davide Vacondio, Luis Enrique Arroyo-Garcia, Michele Bedin, Luigi Balasco, Isabella Schmeh, Melanie Pieber, Anne-Kristin Kukla, Takeo Mukai, Shunichiro Tsuji, Xing-Mei Zhang, Ronny Wickstrom, Klas Blomgren, Robert A. Harris, Ulrika Ådén (2026) Delayed adoptive transfer of bone marrow-derived macrophages modulates post-ischemic inflammation in a model of neonatal hypoxia-ischemia Brain, behavior, and immunity, Vol. 131, Article 106179 (Article in journal) https://dx.doi.org/10.1016/j.bbi.2025.106179

2025

K. Kopaczka, Elena Di Martino, R. Zen, N. Matysiak, Ł. Mielańczyk, S. Bencina, R. Gramignoli, Ulrika Ådén (2025) Human Amnion-Derived Cells for Neonatal Hypoxic-Ischemic Encephalopathy in Mice Neuromethods, p. 157-169 (Chapter in book) https://dx.doi.org/10.1007/978-1-0716-4783-7_12
Katarzyna Kopaczka, Elena Di Martino, Rika Zen, Natalia Matysiak, Łukasz Mielańczyk, Stefan Bencina, Roberto Gramignoli, Ulrika Ådén (2025) Human Amnion-Derived Cells for Neonatal Hypoxic-Ischemic Encephalopathy in Mice Regenerative Cellular Therapies for Neurological Diseases, p. 157-169 (Chapter in book) https://dx.doi.org/10.1007/978-1-0716-4783-7_12

2024

Elena Di Martino, Anoop Ambikan, Daniel Ramskold, Takashi Umekawa, Sarantis Giatrellis, Davide Vacondio, Alejandro Lastra Romero, Marta Gomez Galan, Rickard Sandberg, Ulrika Ådén, Volker M. Lauschke, Ujjwal Neogi, Klas Blomgren, Julianna Kele (2024) Inflammatory, metabolic, and sex-dependent gene-regulatory dynamics of microglia and macrophages in neonatal hippocampus after hypoxia-ischemia iScience, Vol. 27, Article 109346 (Article in journal) https://dx.doi.org/10.1016/j.isci.2024.109346

Research

Hypoxic–ischemic brain injury is a leading cause of neonatal mortality and long-term neurological disability worldwide, yet effective therapeutic options remain limited.

Our lab aims to address this unmet need by uncovering the neuroinflammatory mechanisms that shape brain development and influence vulnerability to injury. Our research focuses on two main areas:

  • The impact of neonatal brain injury on brain homeostasis and repair, with a particular focus on lipid regulation, blood–brain barrier integrity, and scar formation.
  • The role of innate immune cells in post-ischemic neuroinflammation, investigating how these cells contribute to the inflammatory cascade and influence brain injury, recovery, and subsequent development.

CV & Metrics

CV

  • 2023-present : Assistant Professor in Experimental Pediatrics with focus on Perinatal Neuroscience, Linköping University, Sweden
  • 2021-2023 : Postdoctoral Scholar, Department of Neurology, University of California San Francisco, USA
  • 2020 : PhD in Neuroscience, Department of Women’s and Children’s Health, Karolinska Institute, Sweden
  • 2016 : Visiting PhD student, Department of Neurology & Neurological Sciences, Stanford University, USA
  • 2014 : Research Assistant, Department of Neuroscience and Physiology, University of Gothenburg, Sweden
  • 2013 : Visiting Student, Brain Research Centre, University of British Columbia, Vancouver, Canada
  • 2013 : International Master’s Degree In Neuroscience, University of Trieste, Italy

Teaching

  • Teaching assistant in Bachelor course Molecular Genetics and Epigenetics and Master courses Advance Neurobiology and Molecular Genetics and Gene Technology.
  • Coordinator and examiner for PhD course Early brain development: injuries, preclinical models and clinical interventions.
  • Supervisor of 15+ Bachelor, Master and Erasmus students.
  • Co-supervisor of PhD students at Linköping University and Karolinska Institute.

Organisation