Department of Biomedical and Clinical Sciences (BKV)

Wallenberg Centre for Molecular Medicine at LiU

WCMM at LiU focuses on the medicine-technology interface, and build upon our existing strengths in research within medical technology, materials science and bioengineering.

Doesn´t one sperm suffice

Reproduction is, for its comparative strength and dynamic character, a major sentinel of the health of animals and humans. Basic discoveries in relation to sperm selection and preservation of cell integrity have been central in our research.

Tumor Immunology and Immunotherapy

The aims of our research are to uncover the cellular and molecular mechanisms that predispose to systemic and long-term anti-tumor immunity and the mechanisms that drive resistance to immunotherapy.

Haemostasis Research Group in Linköping

We study regulation of platelet activation and interaction with coagulation from biochemistry and genes to clinical studies on antithrombotic drugs in cardiovascular diseases and how covid-19 causes thrombosis. We also develop new diagnostic methods.

Genome integrity: from nuclear structure to telomere protection

We study the molecular mechanisms that preserve genome stability in mammalian cells and their roles in cancer and ageing.

The Böhme Lab

We investigate how the experience of “self” is generated by the brain and body – and what happens if self-other-distinction is altered in psychiatric conditions or through experimental interventions.

RNA in Adaptive Immunity and Autoimmune Disease

A McIntyre Lab at LiU uses cellular and molecular biology approaches, along with computational analysis, to study the adaptive immune system.

Disaster Medicine

Knowledge within the field of disaster medicine forms the basis of the preparedness of the health care system for disastrous events.

Epistemologi och post-Covid

The pandemic has impacted us all, but some more than others. For those who are suffering from post-Covid, the lingering impact is particularly tangible. Interdisciplinary research is needed to understand this new health challenge.

Experimental Orthopedics

The purpose of this research is to ensure and accelerate the healing of injured bones and tendons.The project involves clinical research that builds on our previous experimental work, mainly regarding PTH and bisphosphonates.

Effects of rTMS on alcohol use

Craving alcohol and an impaired ability to stop drinking despite adverse consequences are key features of alcohol addiction. This project aims to find a noninvasive brain stimulation method that can be used as treatment for addiction.

ABOGRAFT

The ABOGRAFT study is a multi-center international study into the effects of providing local antibiotics to prevent joint infection in patients who undergo hip replacement surgery using bone graft.

Cancer

Cancer is a research network for scientists and health care professionals at Linköping University and at the County Council of Östergötland (Region Östergötland). The research is related to cancer diagnosis, pathogenesis and treatment.

Strategic Research Area in Forensic Sciences

The Strategic Research Area in Forensic Sciences is a joint venture between the National Board of Forensic Medicine in Sweden and Linköping University.

Atypical Interaction Conference

Welcome to Linköping University, Sweden and the Atypical Interaction Conference, 10-12 June 2025. Abstract submissions will appear here in November. Abstract submission deadline will be 20 January 2025.

Multi-sectoral Responses to Child Abuse and Neglect in Europe

Multi-Sectoral Responses to Child Abuse and Neglect in Europe (Euro-CAN) is a COST Action network project with participants from several European countries.

Journeys - Safe and Informed Journeys through Barnahus

The overall objective of the JOURNEYS project is to contribute to improved access to child-friendly justice, protection and recovery for child victims and their families.

Bojmar Lab

Cancer is a systemic disease. Our research focuses on understanding crosstalk between different organs in the human body, and how this affects cancer progression. We focus mainly on gastrointestinal cancers and their common hepatic metastasis.

Tick-borne infections

We conduct translational, patient-centered research on tick-borne infections and COVID-19. Collaborative projects form the foundation of the translational research being carried out.

Neurodegeneration

We perform clinical and experimental studies to investigate the role of autophagy in the development of peripheral neuropathy in conditions such as diabetes or physical trauma.

Cell migration in health and disease

Directional cell motility follows us from creation to death and is a vital part of life. Our main interest in this regard is how water flux via AQP contribute to the process of membrane protrusion necessary for directional whole cell translocation.

Genetics and Toxicology in Cancer Chemotherapy and Forensic Sciences

The aim of our research is to identify, validate and implement genetic markers or other biomarkers to predict drug metabolism or drug effects.

Pantazis Laboratory of Cellular Excitability – PaLaCE

In the Pantazis Laboratory of Cellular Excitability - PaLaCE, we employ cutting-edge experimental and computational approaches to understand how the intricate structure of ion channels relates to their function.

Center for Social and Affective Neuroscience - CSAN

Center for Social and Affective Neuroscience (CSAN) integrates knowledge and methodology from different areas of basic and clinical neuroscience.

How to solve murders using postmortem metabolomics and artificial intelligence

Successful efforts from this research environment will be implemented into routine case work and will aid police work in providing investigative leads and new tools to expand objective forensic evidence.

Neuroretreat 2025

Center for Systems Neurobiology at Linköping University is organizing a retreat on 15th to 16th of May, 2025.

Molecular Regulation of Epigenetic Inheritance of Metabolic Disease

New evidence suggests that metabolic memories, set by the parents, can affect eating behavior and obesity in future generations.

Experiencing the Self through Touch

Through functional magnetic resonance imaging (fMRI) this project gathers information about the boundaries between the self and others and compares the outcome of the reactions of neurotypical volunteers with participants with a psychiatric disorder

Auditory neuroscience group

To study the function of these stereocilia, the research group has developed a new type of confocal microscope that makes it possible to directly observe sound-evoked motion.

The Cantù Lab - Genome Regulation in Development and Disease

The Cantù Lab at LiU is focused on one important goal: to discover the mechanisms of genome regulation that drive cell differentiation and specialization during embryonic development.

Studies on chronic lymphocytic leukemia

We reported a novel finding on the highly restricted and biased specificities of CLL Abs some years ago, showing limited target structures for the CLL Abs, which were exposed on oxidized-LDL, apoptotic cells...

Selective vulnerability to neurodegeneration

Neurodegenerative diseases cause stereotypical signs based on the specific brain region that is targeted. We try to understand how unaffected regions resist disease with the hope that these secrets can be transferred to vulnerable brain regions.

Cardiac Rhythm

Ion channels are critical for heart rhythm. They generate and regulate the electric activity that underlies each heart beat.

Research on reproductive endocrinology

Age related decreases in sex steroid production often lead to a number of symptoms and metabolic changes. The research is focusing on these issues with special attention being given to changes in hypothalamic temperature regulation.

The Endoplasmic Reticulum stress response and its role in disease

ER stress is a key molecular link in the pathology of numerus human diseases including metabolic syndrome, and protein misfolding diseases. In my research, I try to understand how this is possible and find new approaches for diagnosis/treatment.

Endocrine tumors

Molecular genetic analysis of endocrine tumors (thyroid, parathyroid, adrenal, neuroendocrine): pathogenesis and development of metastases.

CIRCA – a support for social interaction

CIRCA is a webpage developed to support social interaction for people who find it challenging to partake in conversational activities, for example older aduls who experience memory problems, and their next of kin.

The Nagi Lab

Pain in the ultrafast lane. We are interested in better understanding the peripheral nervous system’s role in acute and persistent pain using microneurography.

Cell signaling in intestinal inflammation

All cells in an organism communicate with one another and with their environment through integrated signaling pathways. By exploring the molecular events that shape cellular decision-making, we can predict and control the fate of individual cells.

The impact of mercury, silver, gold and drugs on the immune system

We have studied adverse effects on the immune system by exposure in vitro and in vivo using both animal models and humans. This has enabled us to establish the threshold dose for effect of different modes of exposure to mercury, silver, and gold.

Bone, mineralization and vascular calcification

Mineralization occurs normally in bone but has, nevertheless, much in common with the pathological process of vascular calcification, which inevitably leads to increased morbidity and mortality.

Molecular physiology of voltage-gated ion channels

Voltage-gated ion channels are key players in all biological systems where they generate and modulate for instance the nervous impulse and pacemaker activity in the heart and the brain.

Cornea Research

Our research team focuses on understanding the origins of blinding diseases of the cornea, evaluating new pharmacologic, surgical, and regenerative therapies to treat corneal disease.

Revealing the secrets of the lysosome

The aim of our research is to elucidate how lysosomal functions are regulated in normal cells and how they are affected in different pathological conditions.

Stopping the propagation of neurodegenerative diseases like Alzheimer’s and Parkinson’s

Neurodegenerative disease like Alzheimer's and Parkinson’s are progressive disease that causes great suffering for the victims and relatives, in addition it cause large economic costs for society.

Strategies to combat the allergy epidemic: Can we predict and prevent childhood allergies?

Childhood immune maturation and allergy development: Epigenetic regulation by maternal immunity and microbial exposure during pregnancy.

Experimental and Clinical Studies of Psoriasis

We are studying the pathogenesis of the disease in experimental systems using broad cell biological techniques. Special interest is devoted to psoriasin which is a small protein...

Ingrid Asp Psoriasis Research Center

Our research program has been made possible by a generous donation from the Ingrid Asp Foundation. Our ultimate goal is to obtain an improved understanding of the pathogenesis of psoriasis and to find new modalities for its therapy.

Young Survivor Unit - YoSU

Our research aims to better understand the development of children who have been seriously ill early in life. Furthermore, to develop and study interventions that, in the long term, increase the children's functioning in everyday life.

Center for Advanced Research in Emergency Response - CARER

A collaboration between LiU and the Swedish Civil Contingencies Agency which aims to consolidate and strengthen LiU's research in risk, response and rescue area.

The McIntyre Lab

Holding a mug, feeling the ground as you walk, petting your furry friend, or hugging your child, all of these touch sensations start with deformation of the skin that the nervous system must process to serve physiological, emotional and social goals.

Swedish-speaking children with developmental language disorder in comparison with second language learners

The focus of this project is language processing in children with Developmental Language Disorder (DLD) and bilingual children learning Swedish as their second language (L2). They are similarly challenged by Swedish grammar.

Precursors of Intentional Communication Skills in Children

The project aims to create a checklist for parents, identify early communicative behaviors in young children up to one year of age, and examine their connection to later linguistic and communicative abilities.

Wallenberg Center for Molecular Medicine Symposium

WCMM at LiU focuses on the medicine-technology interface and build upon our existing strengths in research within molecular medicine, medical technology and bioengineering.

Health examinations of children in out-of-home care

Research has consistently shown, both nationally and internationally, that children and young people placed in community care face a higher risk of poor health outcomes.

The Igelström lab

Everyday sensory stimuli often feel overwhelming for autistic people, causing stress and exhaustion. We study brain processes related to sensory problems in autism and other neurodevelopmental conditions.

N-forte trial

The aim of the N-forte trial is to explore how breast milk composition influences the development of NEC, sepsis and neurological impairment in extremely preterm infants in order to improve future treatments in this patient group.

The Olausson Lab

Human touch is a powerful way of evoking emotions. What is the functional significance of the system for ultrafast nociceptors that we recently discovered? How does the nervous system distinguish social and self-touch? Our lab is looking for answers.

Viral vaccines focused on influenza and HIV

Our research will provide new knowledge about how effective vaccination can be done with a focus on viral infections. Why and how vaccines work is an exciting research area in which we operate.

It’s in your DNA - your body’s experiences become imprinted as methylation signatures!

Our research explores how infections like COVID-19 and tuberculosis alter DNA through epigenetic changes. Tuberculosis exposure leaves marks in immune and other cells. COVID-19 also rewires immune cell DNA, offering diagnostic insights.

The Engblom Lab

At the Engblom Lab, we investigate the mechanisms and circuits underpinning the aversive affective states and the depressive symptoms accompanying inflammatory diseases and major depression.

The Morrison Lab

The Morrison Lab: Embodied Brain Lab investigates emotional and social aspects of both touch and pain, and how these influence - and are influenced by - behavior.

Leukemia and blood stem cells

Regulation of survival and differentiation of hematopoietic stem cells and leukemia-initiating cells.

Individualised diagnosis and treatment of tuberculosis

Our general aim is to individualise and thereby optimize management of clinical TB by new methods and strategies. The research group consists of specialists in tuberculosis from different professions.

The Fredriksson Lab

The main challenge of addiction treatment is high relapse rates during abstinence. We use preclinical models to study the mechanisms and circuits that mediate opioid relapse and craving.

Emergency Medicine Research Center

The research and development unit of the Emergency Department at Linköping University Hospital was started in 2016. In 2021, the Emergency Department became Sweden's first university healthcare unit in emergency medicine.

The Johansson Capusan Lab

We explore genetic and environmental risk and follow clinical outcomes in addiction medicine using national and regional Swedish registers with the overall aim to improve healthcare for addiction.

The Barbier Lab

We explore the neural circuits and molecular mechanisms that underlie alcohol use- and anxiety disorders. Additionally, we examine potential common mechanisms that may link these two disorders.

The Szczot Lab

External stimuli in concert with internal state guide behaviors, moods and choices. Deciphering how sensory representation is altered by injury, might have major implications for the treatment of somatosensory dysfunctions like chronic pain.

The Heilig Translational Psychiatry Lab: Clinical group

We use brain imaging, behavior analysis and pharmacology to study how a breakdown of coping with stress and regulating negative emotions results in disorders such as depression, post-traumatic stress and addiction.

The Augier Lab

Addiction leads to a progressively increased choice of drugs over healthy rewards such as food and social interaction. We investigate the mechanisms and circuits driving individual variability to substance use disorder.

The Heilig Translational Psychiatry Lab: Preclinical group

We use animal models to discover molecular and neural mechanisms that cause a progression into alcohol addiction, and to identify novel targets for pharmacological addiction treatments.

Robust, Realistic and Reliable Measurements of Metabolism

New measuring techniques have always been one of the most important driving forces for medical development. The methods developed in this project could allow us to look further into the body: into the highly detailed metabolism of the human cells.

Educational Equality for Children with Developmental Language Disorder. A Study of Goal Attainment, Experience and Participation

The project aims to generate knowledge that can be used to improve the organization of learning activities for children with developmental language disorder (DLD), as well as to improve the experience of school attendance among these children.

EpiChrom 2021

Welcome to EpiChrom 2021, Swedish Epigenetics and Chromatin Meeting. Organized by Linköping University on September 2nd to September 3rd, 2021.

Research Focus Dermatology

The ultimate goal of the research is to increase the understanding of the underlying mechanisms of skin diseases, in order to facilitate the development of more specific treatments and clinical care.

M4-health: the basis for general AI in health care

In the VR funded project “M4-health: the basis for general AI in health care” we make way for a more general and flexible type of AI in health care.

Clinical Ophthalmic Research

Sight is our most important source of information about the world around us, and is the mind that engages most of the brain. Preserved vision is a basic prerequisite for maintaining one's independence in everyday activities, especially in old age.

Knowledge Driven Drug Development

In this project, financed by VR medicine’s investment in pharmacy, the researchers are working with AstraZeneca to develop a new type of knowledge driven drug development.

Treatment of meniscus injuries

Keyhole surgery has long been the most common treatment for suspected meniscus injury. But the benefits of the operation are now being questioned and instead replaced with training primarily for middle-aged and older people with knee pain.

Barnafrid

Barnafrid is a national knowledge center with the aim of assembling and disseminating knowledge about violence and other abuses against children. It is a government commission that was assigned Linköping University in 2015.

Clinical and experimental rheumatology

A long-term ambition is to contribute to increased understanding of underlying mechanisms for the disease onset, progress and perceived quality of life in systemic inflammatory diseases, especially with regard to systemic lupus erythematosus (SLE)

Maternal obesity and perinatal outcome

How does maternal obesity affect the course of labor? We have shown that obese women experience a longer dilation phase during childbirth. Does the same apply to women who, for various reasons, require labor induction?

Gastroviruses

Rotavirus and norovirus (the winter vomiting disease, “vinterkräksjuka”) are major causes of acute diarrhea worldwide. The underlying disease mechanisms are still unresolved.

TPMT nomenclature committee

Our aim is to maintain a common, logical nomenclature system for thiopurine methyltransferase (TPMT) alleles in humans.

Skin cancer prevention in primary care

Studies to improve survival and quality of life among women with gynaecological cancer

We want to improve the treatment for patients with gynaecological cancer with the aim of prolonging survival without causing short- and long-term side-effects affecting daily life activities.

Center for Systems Neurobiology

Center for Systems Neurobiology is a strategic effort from Linköping University (LiU) and Region Östergötland aimed at strengthening research within the medical field.

Microbial pathogenisity in tuberculosis

Our research focuses on the beneficial role of innate immune cells and their cooperation for the control of Mtb during simultaneous co-infection.

Psychosocial Obstetrics and Reproduction

We study IVF, oocytes and sperm donation and surrogate motherhood – from the very first conversation at the clinic to follow up several years later.

Applied Auditory Research

The hearing science group at LiU conduct research in several areas such as hearing physiology, diagnosis of hearing loss, rehabilitation and intervention, hearing aids and cochlear implants, and digital signal processing.

Reproduction and Neuro Immunology

The general purpose of our research is to reveal mechanisms of immune tolerance in pregnancy and how failure of tolerance mechanisms can lead to pregnancy complications.

Oncopharmacology

Our research is within the field of Drug research and Onco-pharmacology. Our aim is to identify drugs with new mechanisms of action, and try to develop drug candidates for clinical use.

Importance of pharmacogenetics for individualising chemotherapy

In addition to cellular studies, we study TPMT and the various genetic variants using recombinant protein. We use biophysical techniques to study the difference in protein stability and drug affinity between TPMT and other genetic varieties.

Head and Neck Cancer

We aim to study the signaling pathways involved in response/resistance to cisplatin, cetuximab, and radiotherapy in order to find new predictive markers and new targets for therapy