Department of Biomedical and Clinical Sciences (BKV)

Wallenberg Centre for Molecular Medicine at LiU

WCMM at LiU focuses on the medicine-technology interface, and build upon our existing strengths in research within medical technology, materials science and bioengineering.

The McIntyre Lab

Holding a mug, feeling the ground as you walk, petting your furry friend, or hugging your child, all of these touch sensations start with deformation of the skin that the nervous system must process to serve physiological, emotional and social goals.

Journeys - Safe and Informed Journeys through Barnahus

The overall objective of the JOURNEYS project is to contribute to improved access to child-friendly justice, protection and recovery for child victims and their families.

The Igelström lab

Everyday sensory stimuli often feel overwhelming for autistic people, causing stress and exhaustion. We study brain processes related to sensory problems in autism and other neurodevelopmental conditions.

N-forte trial

The aim of the N-forte trial is to explore how breast milk composition influences the development of NEC, sepsis and neurological impairment in extremely preterm infants in order to improve future treatments in this patient group.

Pantazis Laboratory of Cellular Excitability – PaLaCE

In the Pantazis Laboratory of Cellular Excitability - PaLaCE, we employ cutting-edge experimental and computational approaches to understand how the intricate structure of ion channels relates to their function.

Epistemologi och post-Covid

The pandemic has impacted us all, but some more than others. For those who are suffering from post-Covid, the lingering impact is particularly tangible. Interdisciplinary research is needed to understand this new health challenge.

Pragmatic Research in Orthopedics - PRIO

Pragmatic Research in Orthopedics is a research group that aim to optimize the quality of care within the field of orthopedic surgery. We have a strong focus on the orthopedic interventions aimed at the lower extremities.

The Olausson Lab

Human touch is a powerful way of evoking emotions. What is the functional significance of the system for ultrafast nociceptors that we recently discovered? How does the nervous system distinguish social and self-touch? Our lab is looking for answers.

Center for Social and Affective Neuroscience - CSAN

Center for Social and Affective Neuroscience (CSAN) integrates knowledge and methodology from different areas of basic and clinical neuroscience.

Experimental Orthopedics

The purpose of this research is to ensure and accelerate the healing of injured bones and tendons.The project involves clinical research that builds on our previous experimental work, mainly regarding PTH and bisphosphonates.

Doesn´t one sperm suffice

Reproduction is, for its comparative strength and dynamic character, a major sentinel of the health of animals and humans. Basic discoveries in relation to sperm selection and preservation of cell integrity have been central in our research.

Cell signaling in intestinal inflammation

All cells in an organism communicate with one another and with their environment through integrated signaling pathways. By exploring the molecular events that shape cellular decision-making, we can predict and control the fate of individual cells.

Viral vaccines focused on influenza and HIV

Our research will provide new knowledge about how effective vaccination can be done with a focus on viral infections. Why and how vaccines work is an exciting research area in which we operate.

Bone, mineralization and vascular calcification

Mineralization occurs normally in bone but has, nevertheless, much in common with the pathological process of vascular calcification, which inevitably leads to increased morbidity and mortality.

Molecular physiology of voltage-gated ion channels

Voltage-gated ion channels are key players in all biological systems where they generate and modulate for instance the nervous impulse and pacemaker activity in the heart and the brain.

It’s in your DNA - your body’s experiences become imprinted as methylation signatures!

Our research explores how infections like COVID-19 and tuberculosis alter DNA through epigenetic changes. Tuberculosis exposure leaves marks in immune and other cells. COVID-19 also rewires immune cell DNA, offering diagnostic insights.

The Engblom Lab

At the Engblom Lab, we investigate the mechanisms and circuits underpinning the aversive affective states and the depressive symptoms accompanying inflammatory diseases and major depression.

Auditory neuroscience group

To study the function of these stereocilia, the research group has developed a new type of confocal microscope that makes it possible to directly observe sound-evoked motion.

The Morrison Lab

The Morrison Lab: Embodied Brain Lab investigates emotional and social aspects of both touch and pain, and how these influence - and are influenced by - behavior.

Studies on chronic lymphocytic leukemia

We reported a novel finding on the highly restricted and biased specificities of CLL Abs some years ago, showing limited target structures for the CLL Abs, which were exposed on oxidized-LDL, apoptotic cells...

Molecular Regulation of Epigenetic Inheritance of Metabolic Disease

New evidence suggests that metabolic memories, set by the parents, can affect eating behavior and obesity in future generations.

Strategies to combat the allergy epidemic: Can we predict and prevent childhood allergies?

Childhood immune maturation and allergy development: Epigenetic regulation by maternal immunity and microbial exposure during pregnancy.

The Nestor Lab

Our research aims to understand the function of DNA methylation in the biology of human CD4+ T-cells, and use this knowledge to dissect its role in disease.

Stopping the propagation of neurodegenerative diseases like Alzheimer’s and Parkinson’s

Neurodegenerative disease like Alzheimer's and Parkinson’s are progressive disease that causes great suffering for the victims and relatives, in addition it cause large economic costs for society.

Revealing the secrets of the lysosome

The aim of our research is to elucidate how lysosomal functions are regulated in normal cells and how they are affected in different pathological conditions.

Cornea Research

Our research team focuses on understanding the origins of blinding diseases of the cornea, evaluating new pharmacologic, surgical, and regenerative therapies to treat corneal disease.

Experimental and Clinical Studies of Psoriasis

We are studying the pathogenesis of the disease in experimental systems using broad cell biological techniques. Special interest is devoted to psoriasin which is a small protein...

Ingrid Asp Psoriasis Research Center

Our research program has been made possible by a generous donation from the Ingrid Asp Foundation. Our ultimate goal is to obtain an improved understanding of the pathogenesis of psoriasis and to find new modalities for its therapy.

How to solve murders using postmortem metabolomics and artificial intelligence

Successful efforts from this research environment will be implemented into routine case work and will aid police work in providing investigative leads and new tools to expand objective forensic evidence.

CIRCA – a support for social interaction

CIRCA is a webpage developed to support social interaction for people who find it challenging to partake in conversational activities, for example older aduls who experience memory problems, and their next of kin.

Bojmar Lab

Cancer is a systemic disease. Our research focuses on understanding crosstalk between different organs in the human body, and how this affects cancer progression. We focus mainly on gastrointestinal cancers and their common hepatic metastasis.

Disaster Medicine

Knowledge within the field of disaster medicine forms the basis of the preparedness of the health care system for disastrous events.

Multi-sectoral Responses to Child Abuse and Neglect in Europe

Multi-Sectoral Responses to Child Abuse and Neglect in Europe (Euro-CAN) is a COST Action network project with participants from several European countries.

Leukemia and blood stem cells

Regulation of survival and differentiation of hematopoietic stem cells and leukemia-initiating cells.

Individualised diagnosis and treatment of tuberculosis

Our general aim is to individualise and thereby optimize management of clinical TB by new methods and strategies. The research group consists of specialists in tuberculosis from different professions.

ABOGRAFT

The ABOGRAFT study is a multi-center international study into the effects of providing local antibiotics to prevent joint infection in patients who undergo hip replacement surgery using bone graft.

The Fredriksson Lab

The main challenge of addiction treatment is high relapse rates during abstinence. We use preclinical models to study the mechanisms and circuits that mediate opioid relapse and craving.

The Johansson Capusan Lab

We explore genetic and environmental risk and follow clinical outcomes in addiction medicine using national and regional Swedish registers with the overall aim to improve healthcare for addiction.

Emergency Medicine Research Center

The research and development unit of the Emergency Department at Linköping University Hospital was started in 2016. In 2021, the Emergency Department became Sweden's first university healthcare unit in emergency medicine.

The Barbier Lab

We explore the neural circuits and molecular mechanisms that underlie alcohol use- and anxiety disorders. Additionally, we examine potential common mechanisms that may link these two disorders.

The Cantù Lab - Genome Regulation in Development and Disease

The Cantù Lab at LiU is focused on one important goal: to discover the mechanisms of genome regulation that drive cell differentiation and specialization during embryonic development.

The Szczot Lab

External stimuli in concert with internal state guide behaviors, moods and choices. Deciphering how sensory representation is altered by injury, might have major implications for the treatment of somatosensory dysfunctions like chronic pain.

The Zetterqvist Lab

Our research group addresses nonsuicidal self-injury (NSSI) which is a significant mental health issue in adolescents and linked with impairments in emotion regulation. We are dedicated to developing novel approaches for preventing and treating NSSI.

The Heilig Translational Psychiatry Lab: Clinical group

We use brain imaging, behavior analysis and pharmacology to study how a breakdown of coping with stress and regulating negative emotions results in disorders such as depression, post-traumatic stress and addiction.

The Augier Lab

Addiction leads to a progressively increased choice of drugs over healthy rewards such as food and social interaction. We investigate the mechanisms and circuits driving individual variability to substance use disorder.

The Heilig Translational Psychiatry Lab: Preclinical group

We use animal models to discover molecular and neural mechanisms that cause a progression into alcohol addiction, and to identify novel targets for pharmacological addiction treatments.

The Böhme Lab

We investigate how the experience of “self” is generated by the brain and body – and what happens if self-other-distinction is altered in psychiatric conditions or through experimental interventions.

Robust, Realistic and Reliable Measurements of Metabolism

New measuring techniques have always been one of the most important driving forces for medical development. The methods developed in this project could allow us to look further into the body: into the highly detailed metabolism of the human cells.

Precursors of Intentional Communication Skills in Children

The project aims to create a checklist for parents, identify early communicative behaviors in young children up to one year of age, and examine their connection to later linguistic and communicative abilities.

Young Survivor Unit - YoSU

Our research aims to better understand the development of children who have been seriously ill early in life. Furthermore, to develop and study interventions that, in the long term, increase the children's functioning in everyday life.

Haemostasis Research Group in Linköping

We study regulation of platelet activation and interaction with coagulation from biochemistry and genes to clinical studies on antithrombotic drugs in cardiovascular diseases and how covid-19 causes thrombosis. We also develop new diagnostic methods.

Educational Equality for Children with Developmental Language Disorder. A Study of Goal Attainment, Experience and Participation

The project aims to generate knowledge that can be used to improve the organization of learning activities for children with developmental language disorder (DLD), as well as to improve the experience of school attendance among these children.

EpiChrom 2021

Welcome to EpiChrom 2021, Swedish Epigenetics and Chromatin Meeting. Organized by Linköping University on September 2nd to September 3rd, 2021.

Selective vulnerability to neurodegeneration

Neurodegenerative diseases cause stereotypical signs based on the specific brain region that is targeted. We try to understand how unaffected regions resist disease with the hope that these secrets can be transferred to vulnerable brain regions.

Cardiac Rhythm

Ion channels are critical for heart rhythm. They generate and regulate the electric activity that underlies each heart beat.

Research Focus Dermatology

The ultimate goal of the research is to increase the understanding of the underlying mechanisms of skin diseases, in order to facilitate the development of more specific treatments and clinical care.

M4-health: the basis for general AI in health care

In the VR funded project “M4-health: the basis for general AI in health care” we make way for a more general and flexible type of AI in health care.

Experiencing the Self through Touch

Through functional magnetic resonance imaging (fMRI) this project gathers information about the boundaries between the self and others and compares the outcome of the reactions of neurotypical volunteers with participants with a psychiatric disorder

Clinical Ophthalmic Research

Sight is our most important source of information about the world around us, and is the mind that engages most of the brain. Preserved vision is a basic prerequisite for maintaining one's independence in everyday activities, especially in old age.

Cell migration in health and disease

Directional cell motility follows us from creation to death and is a vital part of life. Our main interest in this regard is how water flux via AQP contribute to the process of membrane protrusion necessary for directional whole cell translocation.

The Endoplasmic Reticulum stress response and its role in disease

ER stress is a key molecular link in the pathology of numerus human diseases including metabolic syndrome, and protein misfolding diseases. In my research, I try to understand how this is possible and find new approaches for diagnosis/treatment.

Knowledge Driven Drug Development

In this project, financed by VR medicine’s investment in pharmacy, the researchers are working with AstraZeneca to develop a new type of knowledge driven drug development.

Treatment of meniscus injuries

Keyhole surgery has long been the most common treatment for suspected meniscus injury. But the benefits of the operation are now being questioned and instead replaced with training primarily for middle-aged and older people with knee pain.

Barnafrid

Barnafrid is a national knowledge center with the aim of assembling and disseminating knowledge about violence and other abuses against children. It is a government commission that was assigned Linköping University in 2015.

Effects of rTMS on alcohol use

Craving alcohol and an impaired ability to stop drinking despite adverse consequences are key features of alcohol addiction. This project aims to find a noninvasive brain stimulation method that can be used as treatment for addiction.

Clinical and experimental rheumatology

A long-term ambition is to contribute to increased understanding of underlying mechanisms for the disease onset, progress and perceived quality of life in systemic inflammatory diseases, especially with regard to systemic lupus erythematosus (SLE)

Neurodegeneration

We perform clinical and experimental studies to investigate the role of autophagy in the development of peripheral neuropathy in conditions such as diabetes or physical trauma.

Endocrine tumors

Molecular genetic analysis of endocrine tumors (thyroid, parathyroid, adrenal, neuroendocrine): pathogenesis and development of metastases.

The impact of mercury, silver, gold and drugs on the immune system

We have studied adverse effects on the immune system by exposure in vitro and in vivo using both animal models and humans. This has enabled us to establish the threshold dose for effect of different modes of exposure to mercury, silver, and gold.

Research on reproductive endocrinology

Age related decreases in sex steroid production often lead to a number of symptoms and metabolic changes. The research is focusing on these issues with special attention being given to changes in hypothalamic temperature regulation.

Genetics and Toxicology in Cancer Chemotherapy and Forensic Sciences

The aim of our research is to identify, validate and implement genetic markers or other biomarkers to predict drug metabolism or drug effects.

Tick-borne infections

Gastroviruses

Rotavirus and norovirus (the winter vomiting disease, “vinterkräksjuka”) are major causes of acute diarrhea worldwide. The underlying disease mechanisms are still unresolved.

TPMT nomenclature committee

Our aim is to maintain a common, logical nomenclature system for thiopurine methyltransferase (TPMT) alleles in humans.

Skin cancer prevention in primary care

Studies to improve survival and quality of life among women with gynaecological cancer

We want to improve the treatment for patients with gynaecological cancer with the aim of prolonging survival without causing short- and long-term side-effects affecting daily life activities.

Center for Systems Neurobiology

Center for Systems Neurobiology is a strategic effort from Linköping University (LiU) and Region Östergötland aimed at strengthening research within the medical field.

Microbial pathogenisity in tuberculosis

Our research focuses on the beneficial role of innate immune cells and their cooperation for the control of Mtb during simultaneous co-infection.

Psychosocial Obstetrics and Reproduction

We study IVF, oocytes and sperm donation and surrogate motherhood – from the very first conversation at the clinic to follow up several years later.

Applied Auditory Research

The hearing science group at LiU conduct research in several areas such as hearing physiology, diagnosis of hearing loss, rehabilitation and intervention, hearing aids and cochlear implants, and digital signal processing.

Reproduction and Neuro Immunology

The general purpose of our research is to reveal mechanisms of immune tolerance in pregnancy and how failure of tolerance mechanisms can lead to pregnancy complications.

Oncopharmacology

Our research is within the field of Drug research and Onco-pharmacology. Our aim is to identify drugs with new mechanisms of action, and try to develop drug candidates for clinical use.

Importance of pharmacogenetics for individualising chemotherapy

In addition to cellular studies, we study TPMT and the various genetic variants using recombinant protein. We use biophysical techniques to study the difference in protein stability and drug affinity between TPMT and other genetic varieties.

Head and Neck Cancer

We aim to study the signaling pathways involved in response/resistance to cisplatin, cetuximab, and radiotherapy in order to find new predictive markers and new targets for therapy

Center for Social and Affective Neuroscience - CSAN

Center for Social and Affective Neuroscience (CSAN) integrates knowledge and methodology from different areas of basic and clinical neuroscience.

Division of Clinical Chemistry and Pharmacology (KKF)

The Division of Clinical Chemistry and Pharmacology (KKF) conducts research and education that includes the subject areas of anesthesiology/intensive care, pharmacology and clinical pharmacology, forensic sciences and clinical chemistry.

Division of Inflammation and Infection (II)

The Division of Inflammation and Infection (II) includes clinical subject areas such as Immunology, Rheumatology, Pathology and Microbiology.

Division of Molecular Medicine and Virology (MMV)

At the division, the research involves studies on the molecular biology level as well as studies of biological effects on cells, on tissue, and organisms. We are also involved in medical and biomedical education programs.

Division of Sensory Organs and Communication (SOK)

At the Division of Sensory Organs and Communication, research focusing on human communication is carried out.

Division of Surgery, Orthopedics and Oncology (KOO)

We carry out research in the fields of experimental orthopedics, surgery and oncology.

Division of Administrative Support (VS)

The Division of Administrative Support at BKV provides professional and effective administrative support to employees, students and collaboration partners with the aim of supporting research, education and collaboration.