Estelle Barbier

Research

The Barbier Lab

We explore the neural circuits and molecular mechanisms that underlie alcohol use- and anxiety disorders. Additionally, we examine potential common mechanisms that may link these two disorders.

News

Two researchers in lab coats are working in a lab.

How fear memories get stuck in some brains

Researchers at Linköping University have discovered a biological mechanism that increases the strength with which fear memories are stored in the brain. The study identifies shared mechanisms behind anxiety and alcohol dependence.

Mechanism behind compulsive alcohol use revealed

A small group of nerve cells in the brain determines whether an individual continues to consume alcohol even when it has negative consequences. The scientists have identified a mechanism that may be a suitable target for treatment by medication.

People with alcohol dependency lack important enzyme

A research group under the leadership of Professor Markus Heilig has identified an enzyme whose production is turned off in nerve cells of the frontal lobe when alcohol dependence develops.

Publications

Publications in DiVA

2024

Sanne Toivainen Eloff, Michele Petrella, Li Xu, Esther Visser, Tamina Weiss, Sofia Vellere, Zane Zeier, Claes Wahlestedt, Estelle Barbier, Esi Domi, Markus Heilig (2024)

Generation and Characterization of a Novel Prkcd-Cre Rat Model Journal of Neuroscience, Vol. 44, Article e0528242024 (Article in journal)

https://dx.doi.org/10.1523/JNEUROSCI.0528-24.2024

Kanat Chanthongdee, Yerko Fuentealba, Thor Wahlestedt, Lou Foulhac, Tetiana Kardash, Andrea Coppola, Markus Heilig, Estelle Barbier (2024)

Comprehensive ethological analysis of fear expression in rats using DeepLabCut and SimBA machine learning model Frontiers in Behavioral Neuroscience, Vol. 18, Article 1440601 (Article in journal)

https://dx.doi.org/10.3389/fnbeh.2024.1440601

Michele Petrella, Anna Maria Borruto, Lorenzo Curti, Ana Domi, Esi Domi, Li Xu, Estelle Barbier, Alice Ilari, Markus Heilig, Friedbert Weiss, Guido Mannaioni, Alessio Masi, Roberto Ciccocioppo (2024)

Pharmacological blockage of NOP receptors decreases ventral tegmental area dopamine neuronal activity through GABAB receptor-mediated mechanism Neuropharmacology, Vol. 248, Article 109866 (Article in journal)

https://dx.doi.org/10.1016/j.neuropharm.2024.109866

Organisation

A researcher is looking at encased samples in a lab.

Center for Social and Affective Neuroscience - CSAN

Center for Social and Affective Neuroscience (CSAN) integrates knowledge and methodology from different areas of basic and clinical neuroscience.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.