Photo of Johan Karlsson

Johan Karlsson

Assistant Professor

Delivery is a major barrier to realize the transformative potential of RNA-based therapies. We're engineering innovative biomaterials that can spontaneously self-assemble with RNA molecules and form nanoparticles for precision delivery to enable treatments for unmet therapeutic needs.

To advance the field of nanomedicine, we are developing new nanoparticle design principles to facilitate nano-mediated delivery to targeted organs and highly specific delivery to cells involved in the diseases progression to enable precise therapies. We’re through our research establishing the relationship between chemical structures and activity of nanoparticles. One of our focuses is immunotherapy, since our immune system has the inherent capacity to provide protection from components/pathogens causing diseases. We’re engineering nanoparticles to program patients’ immune cells and cancer cells to induce signaling that would unleash the patient’s immune system full potential to recognize and fight cancer cells. Our research program is also pioneering technical advancements to enable new avenues for RNA-based therapies that would help patients having central nervous system (CNS) disorders.

Publications

2023

Elana Ben-Akiva, Johan Karlsson, Shayan Hemmati, Hongzhe Yu, Stephany Y. Tzeng, Drew M. Pardoll, Jordan J. Green (2023) Biodegradable lipophilic polymeric mRNA nanoparticles for ligand-free targeting of splenic dendritic cells for cancer vaccination Proceedings of the National Academy of Sciences, Vol. 120 Continue to DOI

2022

Elana Ben-Akiva, Johan Karlsson, Stephany Y. Tzeng, Hongzhe Yu, Jordan J. Green (2022) Chapter Two - Delivery strategies for ex vivo and in vivo T-cell reprogramming Systemic Drug Delivery Strategies, p. 31-62

2021

Johan Karlsson, Stephany Y Tzeng, Shayan Hemmati, Kathryn M Luly, Olivia Choi, Yuan Rui, David R Wilson, Kristen L Kozielski, Alfredo Quiñones-Hinojosa, Jordan J Green (2021) Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy. Advanced Functional Materials, Vol. 31, Article 2009768 Continue to DOI
Johan Karlsson, Kathryn M Luly, Stephany Y Tzeng, Jordan J Green (2021) Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies. Advanced Drug Delivery Reviews, Vol. 179, p. 113999-, Article 113999 Continue to DOI

2020

Johan Karlsson, Kelly R Rhodes, Jordan J Green, Stephany Y Tzeng (2020) Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities. Expert Opinion on Drug Delivery, Vol. 17, p. 1395-1410 Continue to DOI