To advance the field of nanomedicine, we are developing new nanoparticle design principles to facilitate nano-mediated delivery to targeted organs and highly specific delivery to cells involved in the diseases progression to enable precise therapies. We’re through our research establishing the relationship between chemical structures and activity of nanoparticles. One of our focuses is immunotherapy, since our immune system has the inherent capacity to provide protection from components/pathogens causing diseases. We’re engineering nanoparticles to program patients’ immune cells and cancer cells to induce signaling that would unleash the patient’s immune system full potential to recognize and fight cancer cells. Our research program is also pioneering technical advancements to enable new avenues for RNA-based therapies that would help patients having central nervous system (CNS) disorders.
Johan Karlsson
Assistant Professor
Delivery is a major barrier to realize the transformative potential of RNA-based therapies. We're engineering innovative biomaterials that can spontaneously self-assemble with RNA molecules and form nanoparticles for precision delivery to enable treatments for unmet therapeutic needs.
Publications
2023
Biodegradable lipophilic polymeric mRNA nanoparticles for ligand-free targeting of splenic dendritic cells for cancer vaccination
Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, Article e2301606120
(Article in journal)
https://dx.doi.org/10.1073/pnas.2301606120
2022
Delivery strategies for ex vivo and in vivo T-cell reprogramming
Systemic Drug Delivery Strategies, p. 31-62
(Chapter in book)
https://dx.doi.org/10.1016/B978-0-323-85781-9.00002-6
2021
Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy
Advanced Functional Materials, Vol. 31, Article 2009768
(Article in journal)
https://dx.doi.org/10.1002/adfm.202009768
Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies
Advanced Drug Delivery Reviews, Vol. 179, Article 113999
(Article in journal)
https://dx.doi.org/10.1016/j.addr.2021.113999
2020
Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities
Expert Opinion on Drug Delivery, Vol. 17, p. 1395-1410
(Article in journal)
https://dx.doi.org/10.1080/17425247.2020.1796628