Lovisa Holm

Principal Research Engineer

Publications

2026

Lars Östman Vasko, Elisabeth Paul, He Zhang, Evelina Larsson, Irene Perini, Lilly Schwieler, Sophie Erhardt, Lovisa Holm, Åsa Axén, Leah Mayo, Markus Heilig, Andrea Johansson Capusan (2026)

The role of proinflammatory response and the kynurenine pathway in the association between childhood maltreatment and lifetime substance use disorder NEUROBIOLOGY OF STRESS, Vol. 42, Article 100820 (Article in journal)

https://dx.doi.org/10.1016/j.ynstr.2026.100820

2023

Esi Domi, Li Xu, Sanne Toivainen Eloff, Joost Wiskerke, Andrea Coppola, Lovisa Holm, Eric Augier, Michele Petrella, Markus Heilig (2023)

Activation of GABA(B) receptors in central amygdala attenuates activity of PKC delta plus neurons and suppresses punishment-resistant alcohol self-administration in rats Neuropsychopharmacology, Vol. 48, p. 1386-1395 (Article in journal)

https://dx.doi.org/10.1038/s41386-023-01543-1

2022

Elisabeth Paul, Lilly Schwieler, Sophie Erhardt, Sandra Boda, Ada Trepci, Robin Kämpe, Anna Asratian, Lovisa Holm, Adam Yngve, Robert Dantzer, Markus Heilig, Paul J. Hamilton, Martin Samuelsson (2022)

Peripheral and central kynurenine pathway abnormalities in major depression Brain, behavior, and immunity, Vol. 101, p. 136-145 (Article in journal)

https://dx.doi.org/10.1016/j.bbi.2022.01.002

2021

Esi Domi, Li Xu, Sanne Toivainen, Anton Nordeman, Francesco Gobbo, Marco Venniro, Yavin Shaham, Robert O. Messing, Esther Visser, Michel C. van den Oever, Lovisa Holm, Estelle Barbier, Eric Augier, Markus Heilig (2021)

A neural substrate of compulsive alcohol use Science Advances, Vol. 7, Article eabg9045 (Article in journal)

https://dx.doi.org/10.1126/sciadv.abg9045

Riccardo Barchiesi, Kanat Chanthongdee, Esi Domi, Francesco Gobbo, Andrea Coppola, Anna Asratian, Sanne Toivainen, Lovisa Holm, Gaëlle Augier, Li Xu, Eric Augier, Markus Heilig, Estelle Barbier (2021)

Stress-induced escalation of alcohol self-administration, anxiety-like behavior, and elevated amygdala Avp expression in a susceptible subpopulation of rats Addiction Biology, Vol. 26, Article e13009 (Article in journal)

https://dx.doi.org/10.1111/adb.13009

Research

The Heilig Translational Psychiatry Lab: Preclinical group

We use animal models to discover molecular and neural mechanisms that cause a progression into alcohol addiction, and to identify novel targets for pharmacological addiction treatments.

Organisation

researcher applies a very thin filament to the hand to measure properties of nerve cells in the skin

Center for Social and Affective Neuroscience (CSAN)

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

News

Mechanism behind compulsive alcohol use revealed

A small group of nerve cells in the brain determines whether an individual continues to consume alcohol even when it has negative consequences. The scientists have identified a mechanism that may be a suitable target for treatment by medication.