Mikael Sigvardsson

News

illustration of cancer cells and red blood cells in blood vessel.

Possible explanation for long-term effects in leukemia survivors

Contrary to previous belief, stem cells, from which all new blood cells are formed, remain in bone marrow in the blood cancer type acute lymphocytic leukemia. But they have a hidden defect and lose their ability to form new blood cells.

Publications

2026

Johanna Tingvall-Gustafsson, Kim Hellerstedt, Jonas Ungerback, Mikael Sigvardsson (2026)

B-lineage commitment is dependent on a reversible epigenetic switch Genes & Development, Vol. 40, p. 233-254, Article PMID 8711660 (Article in journal)

https://dx.doi.org/10.1101/gad.353002.125

2025

Johanna Tingvall-Gustafsson, Christina T. Jensen, Jonas Ungerback, Mikael Sigvardsson (2025)

Chromatin interaction-based annotation of regulatory elements reveals dynamic promoter-enhancer interactions in lymphocyte development iScience, Vol. 28, Article 112855 (Article in journal)

https://dx.doi.org/10.1016/j.isci.2025.112855

2024

Mikael Sigvardsson (2024)

Early B-Cell Factor 1: An Archetype for a Lineage-Restricted Transcription Factor Linking Development to Disease Transcription factors in blood cell development, p. 143-156 (Chapter in book)

https://dx.doi.org/10.1007/978-3-031-62731-6_7

Image of molecules that will take you to WCMM's homepage.

Wallenberg Centre for Molecular Medicine at LiU

WCMM at LiU focuses on the medicine-technology interface, and build upon our existing strengths in research within medical technology, materials science and bioengineering.

Organisation

Division of Molecular Medicine and Virology (MMV)

At the division, the research involves studies on the molecular biology level as well as studies of biological effects on cells, on tissue, and organisms. We are also involved in medical and biomedical education programs.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.