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Mikael Sigvardsson

Professor

News

illustration of cancer cells and red blood cells in blood vessel.

Possible explanation for long-term effects in leukemia survivors

Contrary to previous belief, stem cells, from which all new blood cells are formed, remain in bone marrow in the blood cancer type acute lymphocytic leukemia. But they have a hidden defect and lose their ability to form new blood cells.

Publications

2024

Mohamed Eldeeb, Anna Konturek-Ciesla, Qinyu Zhang, Shabnam Kharazi, Johanna Tingvall-Gustafsson, Jonas Ungerback, Mikael Sigvardsson, David Bryder (2024) Ontogeny shapes the ability of ETV6::RUNX1 to enhance hematopoietic stem cell self-renewal and disrupt early lymphopoiesis Leukemia, Vol. 38, p. 455-459 (Article in journal) Continue to DOI

2023

Mikael Sigvardsson (2023) Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia Genes & Development, Vol. 37, p. 703-723 (Article, review/survey) Continue to DOI
Monika Dolinska, Huan Cai, Alma Mansson, Jingyi Shen, Pingnan Xiao, Thibault Bouderlique, Xidan Li, Elory Leonard, Marcus Chang, Yuchen Gao, Juan Pablo Medina Giménez, Makoto Kondo, Lakshmi Sandhow, Anne-Sofie Johansson, Stefan Deneberg, Stina Söderlund, Martin Jädersten, Johanna S Ungerstedt, Magnus Tobiasson, Arne Östman, Satu Mustjoki, Leif Stenke, Katarina Le Blanc, Eva S Hellstrom-Lindberg, Sören Lehmann, Marja Ekblom, Ulla Olsson-Strömberg, Mikael Sigvardsson, Hong Qian (2023) Characterization of Bone Marrow Niche in Chronic Myeloid Leukemia Patients Identifies CXCL14 as a New Therapeutic Option Blood, Vol. 142, p. 73-89 (Article in journal) Continue to DOI

Related Research

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Wallenberg Centre for Molecular Medicine at LiU

WCMM at LiU focuses on the medicine-technology interface, and build upon our existing strengths in research within medical technology, materials science and bioengineering.

Organisation

Molecular medicine and virology.

Division of Molecular Medicine and Virology (MMV)

At the division, the research involves studies on the molecular biology level as well as studies of biological effects on cells, on tissue, and organisms. We are also involved in medical and biomedical education programs.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

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