Sensation of human pain: Perception and afferent coding

In my PhD, I have been investigating the mechanisms underlying the comorbidity between attention deficit/hyperactivity disorder (ADHD) and pain. I used behavioral approaches, morphological analysis and in vivo electrophysiology combined with optogenetics in mice.
Currently, I aim to decipher how individual sensory afferents encode painful stimuli by using microneurography (in vivo electrophysiology) and psychophysics in humans.


Key publications

  • Bouchatta O, Aby F, Sifeddine W, Bouali-Benazzouz R, Brochoire L, Manouze H, Fossat P, Ba-M’Hamed S, Bennis M, Landry M (2022). Pain hypersensitivity in a pharmacological mouse model of Attention-Deficit/Hyperactivity Disorder. Proceedings of the National Academy of Sciences, 119(30): e2114094119. doi:10.1073/pnas.2114094119.
  • Aby F, Lorenzo LE, Grivet Z, Bouali-Benazzouz R, Martin H, Valerio S, Whitestone S, Isabel D, Idi W, Bouchatta O, De Deurwaerdere P, Godin AG, Herry C, Fioramonti X, Landry M, De Koninck Y and Fossat P (2022). Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain. Science Advances, 8(30): eabo0689. doi: 10.1126/sciadv.abo0689.