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Otmane Bouchatta

Postdoc

Postdoctoral scientist interested in the sensory physiology of pain in health and disease.

Sensation of human pain: Perception and afferent coding

In my PhD, I have been investigating the mechanisms underlying the comorbidity between attention deficit/hyperactivity disorder (ADHD) and pain. I used behavioral approaches, morphological analysis and in vivo electrophysiology combined with optogenetics in mice.
Currently, I aim to decipher how individual sensory afferents encode painful stimuli by using microneurography (in vivo electrophysiology) and psychophysics in humans.

Publications

Key publications

  • Bouchatta O, Aby F, Sifeddine W, Bouali-Benazzouz R, Brochoire L, Manouze H, Fossat P, Ba-M’Hamed S, Bennis M, Landry M (2022). Pain hypersensitivity in a pharmacological mouse model of Attention-Deficit/Hyperactivity Disorder. Proceedings of the National Academy of Sciences, 119(30): e2114094119. doi:10.1073/pnas.2114094119.
  • Aby F, Lorenzo LE, Grivet Z, Bouali-Benazzouz R, Martin H, Valerio S, Whitestone S, Isabel D, Idi W, Bouchatta O, De Deurwaerdere P, Godin AG, Herry C, Fioramonti X, Landry M, De Koninck Y and Fossat P (2022). Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain. Science Advances, 8(30): eabo0689. doi: 10.1126/sciadv.abo0689.

2024

Huasheng Yu, Saad Nagi, Dmitry Usoskin, Yizhou Hu, Jussi Kupari, Otmane Bouchatta, Hanying Yan, Suna Li Cranfill, Mayank Gautam, Yijing Su, You Lu, James Wymer, Max Glanz, Phillip Albrecht, Hongjun Song, Guo-Li Ming, Stephen Prouty, John Seykora, Hao Wu, Minghong Ma, Andrew Marshall, Frank L. Rice, Mingyao Li, Håkan Olausson, Patrik Ernfors, Wenqin Luo (2024) Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation Nature Neuroscience (Article in journal) Continue to DOI
Kevin Ng, Odai Waleed Mohammad Lafee, Otmane Bouchatta, Adarsh D. Makdani, Andrew G. Marshall, Håkan Olausson, Sarah Mcintyre, Saad Nagi (2024) Human Foot Outperforms the Hand in Mechanical Pain Discrimination eNeuro, Vol. 11, Article 0412232024 (Article in journal) Continue to DOI

2023

Ilias Chaibi, Otmane Bouchatta, Mohamed Bennis, Saadia Ba-Mhamed (2023) The Role of the Anterior Cingulate Cortex in Aggression and Impulsivity Behavioral Neuroscience, Vol. 137, p. 155-169 (Article in journal) Continue to DOI

2022

Otmane Bouchatta, Franck Aby, Wahiba Sifeddine, Rabia Bouali-Benazzouz, Louison Brochoire, Houria Manouze, Pascal Fossat, Saadia Ba M'Hamed, Mohamed Bennis, Marc Landry (2022) Pain hypersensitivity in a pharmacological mouse model of attention-deficit/hyperactivity disorder Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, Article e2114094119 (Article in journal) Continue to DOI

Research

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The Nagi Lab

Pain in the ultrafast lane. We are interested in better understanding the peripheral nervous system’s role in acute and persistent pain using microneurography.

Organisation

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Center for Social and Affective Neuroscience - CSAN

Center for Social and Affective Neuroscience (CSAN) integrates knowledge and methodology from different areas of basic and clinical neuroscience.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

News

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Our sense of touch consists of 16 unique types of nerve cells

No less than 16 different types of nerve cells have been identified by scientists in a new study on the human sense of touch. Comparisons between humans, mice and macaques show both similarities and significant differences.

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