Roland Andersson

Visiting Professor

Epidemiology, pathophysiology, diagnosis and management of acute appendicitis

Patients with acute abdominal pain with suspicion of appendicitis are common. The etiology and pathophysiology of acute appendicitis is not well understood, and the management of patients with suspicion of appendicitis is controversial.

The main goals of this long term project are to elucidate the natural history and to investigate the pathophysiology of acute appendicitis, to improve the clinical diagnosis and to define the role of diagnostic imaging techniques and laparoscopy in the structured management of patients with suspicion of appendicitis.

Within this project we use epidemiologic techniques to analyse different aspects about appendicitis, like mortality, long term associations of appendicitis and appendectomy with other intestinal inflammatory conditions like inflammatory bowel disease and diverticulitis and to analyse the effects of the implementation of the laparoscopic technique in the management of appendicitis.

We also analyse the impact of environmental factors during infancy, mainly breastfeeding and exposure to tobacco, on the risk of having acute appendicitis later in life.

We use immunologic techniques to study the systemic and local inflammatory response in appendicitis to elucidate the pathogenesis of appendicitis and to find useful diagnostic markers of especially advanced appendicitis.

In prospective clinical multicenter studies we search means to improve the clinical diagnosis of appendicitis and to define the role of diagnostic imaging in the structured management of patients with suspicion of appendicitis.

Publications

2025

Martin Salo, Catarina Tiselius, Anders Rosemar, Elin Ost, Sara Sohlberg, Roland Andersson (2025) Swedish national guidelines for diagnosis and management of acute appendicitis in adults and children BJS Open, Vol. 9, Article zrae165 (Article, review/survey) Continue to DOI
Roland Andersson, Elin Moltubak, Kalle Landerholm (2025) Letter to the editor regarding the Alvarado and AIR score in pregnant women European Journal of Trauma and Emergency Surgery, Vol. 51, Article 168 (Article in journal) Continue to DOI
Roland Andersson, Joachim Stark (2025) Diagnostic value of the appendicitis inflammatory response (AIR) score. A systematic review and meta-analysis World Journal of Emergency Surgery, Vol. 20, Article 12 (Article, review/survey) Continue to DOI