Epidemiology, pathophysiology, diagnosis and management of acute appendicitis

Patients with acute abdominal pain with suspicion of appendicitis are common. The etiology and pathophysiology of acute appendicitis is not well understood, and the management of patients with suspicion of appendicitis is controversial.

The main goals of this long term project are to elucidate the natural history and to investigate the pathophysiology of acute appendicitis, to improve the clinical diagnosis and to define the role of diagnostic imaging techniques and laparoscopy in the structured management of patients with suspicion of appendicitis.

Within this project we use epidemiologic techniques to analyse different aspects about appendicitis, like mortality, long term associations of appendicitis and appendectomy with other intestinal inflammatory conditions like inflammatory bowel disease and diverticulitis and to analyse the effects of the implementation of the laparoscopic technique in the management of appendicitis.

We also analyse the impact of environmental factors during infancy, mainly breastfeeding and exposure to tobacco, on the risk of having acute appendicitis later in life.

We use immunologic techniques to study the systemic and local inflammatory response in appendicitis to elucidate the pathogenesis of appendicitis and to find useful diagnostic markers of especially advanced appendicitis.

In prospective clinical multicenter studies we search means to improve the clinical diagnosis of appendicitis and to define the role of diagnostic imaging in the structured management of patients with suspicion of appendicitis.

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2021

Nicola DeAngelis, Fausto Catena, Riccardo Memeo, Federico Coccolini, Aleix Martinez-Perez, Oreste M. Romeo, Belinda De Simone, Salomone Di Saverio, Raffaele Brustia, Rami Rhaiem, Tullio Piardi, Maria Conticchio, Francesco Marchegiani, Nassiba Beghdadi, Fikri M. Abu-Zidan, Ruslan Alikhanov, Marc-Antoine Allard, Niccolo Allievi, Giuliana Amaddeo, Luca Ansaloni, Roland Andersson, Enrico Andolfi, Mohammad Azfar, Miklosh Bala, Amine Benkabbou, Offir Ben-Ishay, Giorgio Bianchi, Walter L. Biffl, Francesco Brunetti, Maria Clotilde Carra, Daniel Casanova, Valerio Celentano, Marco Ceresoli, Osvaldo Chiara, Stefania Cimbanassi, Roberto Bini, Raul Coimbra, Gianm Luigi deAngelis, Francesco Decembrino, Andrea De Palma, Philip R. de Reuver, Carlos Domingo, Christian Cotsoglou, Alessandro Ferrero, Gustavo P. Fraga, Federica Gaiani, Federico Gheza, Angela Gurrado, Ewen Harrison, Angel Henriquez, Stefan Hofmeyr, Roberta Iadarola, Jeffry L. Kashuk, Reza Kianmanesh, Andrew W. Kirkpatrick, Yoram Kluger, Filippo Landi, Serena Langella, Real Lapointe, Bertrand Le Roy, Alain Luciani, Fernando Machado, Umberto Maggi, Ronald V. Maier, Alain Chichom Mefire, Kazuhiro Hiramatsu, Carlos Ordonez, Franca Patrizi, Manuel Planells, Andrew B. Peitzman, Juan Pekolj, Fabiano Perdigao, Bruno M. Pereira, Patrick Pessaux, Michele Pisano, Juan Carlos Puyana, Sandro Rizoli, Luca Portigliotti, Raffaele Romito, Boris Sakakushev, Behnam Sanei, Olivier Scatton, Mario Serradilla-Martin, Anne-Sophie Schneck, Mohammed Lamine Sissoko, Iradj Sobhani, Richard P. ten Broek, Mario Testini, Roberto Valinas, Giorgos Veloudis, Giulio Cesare Vitali, Dieter Weber, Luigi Zorcolo, Felice Giuliante, Paschalis Gavriilidis, David Fuks, Daniele Sommacale (2021) 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy World Journal of Emergency Surgery , Vol. 16 Continue to DOI
Mauro Podda, Roland Andersson, Marja Boermeester, Federico Coccolini, Massimo Sartelli, Ernest E. Moore, Michael Sugrue, Fikri Abu-Zidan, Matti Tolonen, Dimitrios Damaskos, Yoram Kluger, Kjetil Soreide, Adolfo Pisanu, Goran Augustin, Rifat Latifi, Michael Kelly, Ari Leppaniemi, Gustavo P. Fraga, Richard Ten Broek, Edward Tan, Herry Van Goor, Osvaldo Chiara, Ronald V Maier, Francesco Pata, Belinda De Simone, Carlos A. Ordonez, Luca Ansaloni, Fausto Catena, Salomone Di Saverio (2021) Do young patients with high clinical suspicion of appendicitis really need cross-sectional imaging? Proceedings from a highly controversial debate among the experts panel of 2020 WSES Jerusalem guidelines Journal of Trauma and Acute Care Surgery , Vol. 90 , s. E101-E107 Continue to DOI