Evolutionary genetics of ageing and sex differences - Friberg Group


Friberg group

Photo: Karl-Olof Bergman

Research in our group focuses on two fascinating biological phenomena – ageing and sex differences - and their interesting intersection. To answer questions related to these topics we primarily conduct research using the model organism Drosophila melanogaster.

 

Evolution and Genetics of Sexual Dimorphism

In order to successfully transmit their genes to the next generation males and females typically have to overcome rather different challenges. While males face choosy females and stiff competition from other males, females are forced to secure resources enough to produce metabolically expensive eggs and demanding offspring. From this it follows that males and females often are selected towards different reproductive strategies, which set the scene for evolution of sex differences. Sex specific selection pressures have led evolution to produce some of the most beautiful as well as bizarre phenotypes ever witnessed – where the peacock’s train perhaps is the most classic example - but sex differences occur in all types of traits, including morphological, physiological, and not the least behavioral.

 

While it is relatively easy to understand that selection often favors differences between the sexes, it is much more difficult to understand how evolution can generate such differences. The reason to this is than males and females have virtually identical genomes. We are interested in the genetics that makes sex differences possible. Some questions we try to answer are: Do all sex differences result from downstream effects of a single sex determining gene? What role does the X chromosome play in generating sex differences? How does condition influence expression of traits that show sex differences? To address these and related questions we primarily investigate genes which show different expression levels in males females.

 

Evolution and Genetics of Ageing

The fact that everyone eventually ages and dies is something that have generated a tremendous amount of thought and speculation ever since the dawn of man. For more than half a century ageing has now been understood from an evolutionary perspective, but despite an ever increasing research effort our knowledge of its genetic foundation is still very poor. We try to understand what type of mutations that generate ageing, how general condition of individuals affects patterns of ageing, and how genetic variation in ageing is distributed over the genome. To learn more about these questions we conduct various genetic experiments.

 

Evolution and Genetics of Sex Differences in Lifespan and Ageing

Above two research themes converge on the observation that males and females have different lifespan and patterns of ageing, in humans and virtually all other species. Why is this? We investigate several theories with the potential to explain this interesting fact.

 

Find our publications here. 

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Previous members

Robert Griffin (PhD-student), now post doc at University of Queensland, AU 
Rebecca Dean (Post doc), now post doc at University College London, UK
Jaime Grace (Post doc), now assistant professor at Bradley University, US
Marios Thoma (Master student)
Élise Biquand (Project student)
Damien Le Gall (Project student)
Marcus Nyberg (Project student)
Jack Maguire-Baxter (Placement student)
Aivars Cirulis (Research training), now PhD student at Lund University
Fredrik Dölfors (Research training)
Markus Hiltunen (Research training), now PhD student at Uppsala University
Therese Jonsson (Research training)
Preeti Menon (Research training)
Emma Thoren (Research training)
Balaje Vijayaraghavan (Research training)
Cindy Canton (Research technician)
Ilona Flis (Research technician), now PhD-student at Oxford University, UK
Henrik Lysell (Research technician)
Marie Roth (Technician)
Phoebe Elias (Placement student)
Josephine Thompson (Placement student)
Miruna Dumea (Placement student)
Christopher Kimber (Post doc)
Antonino Malacrinò (Post doc), now post doc at Ohio State University, US

 

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