Optical Devices Laboratory

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At Optical Devices Laboratory (ODL) we conduct multidisciplinary research on methods and devices for optical chemical sensing. We work on disposable and autonomous lab-on-a-chip (LOC) systems, and optical devices conceived for universal interfacing to readout instruments, such as cell phones.

Our activities entail optics and fluidics design, micro-fabrication including 3D printed optics and LOC, biochemical analysis integration, instrumentation and data processing. 

Optical devices

We investigate optical principles and their integration within disposable LOC devices, with special focus on coupling to cell phone camera readout. Some examples are illustrated above.


Focusing at short distance from the camera surface is crucial to simplify LOC positioning, and not only demands refocusing but also adaptive focusing to support diverse cameras with the same disposable LOC design. One solution was to configure a sessile drop on a controlled surface and to operate it as a disposable varifocal lens.

ODL has also demonstrated a disposable optical coupler that uses cell phone screens as light sources to perform label-free angle resolved surface plasmon resonance (SPR) detection with the phone camera.

3D printed integrated optics allow us to configure disposable LOCs for universal coupling to cell phone cameras, using our unibody-LOC (ULOC) technology.

LOC systems

At ODL we develop low-cost fast-prototyping alternatives to classical LOC fabrication of PDMS on glass devices. Replacing costly SU-8 templates by versatile stereolithography (SLA) 3D printed templates we are able to produce prototypes for ~0.5 US$, with unlimited number of 3D features for the same cost and at typically 20 min/prototype.

Further simplification can be achieved by transferring all complex fabrication tasks to the 3D printer and collecting all functional features in a single monolithic printout (unibody-LOC, ULOC), which hosts functionalization, transport and actuation features.

Low surface roughness, achievable with SLA printers, enables fabrication of arbitrarily long and geometrically regular open channels, which can be simply sealed with adhesive tape. Printing times of 10 min permit several optimization cycles/day.

ULOC devices have been configured for paper fluidics and classical LOC formats, can integrate optics, finger pumps and check-valves in entirely disposable configurations.

Read more at our old page.

Selected Papers
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German Comina, Anke Suska, Daniel Filippini (2016)

Analytical Methods , Vol.8 , s.6135-6142 Continue to DOI

German Comina, Anke Suska, Daniel Filippini (2016)

Biosensors & bioelectronics , Vol.77 , s.1153-1167 Continue to DOI

German Comina, Anke Suska, Daniel Filippini (2015)

Angewandte Chemie International Edition , Vol.54 , s.8708-8712 Continue to DOI

German Comina, Anke Suska, Daniel Filippini (2014)

Lab on a Chip , Vol.14 , s.2978-2982 Continue to DOI

German Comina, Anke Suska, Daniel Filippini (2014)

Lab on a Chip , Vol.14 , s.424-430 Continue to DOI

Pakorn Preechaburana, Anke Suska, Daniel Filippini (2014)

Trends in Biotechnology , Vol.32 , s.351-355 Continue to DOI

Pakorn Preechaburana, Marcos Gonzalez, Anke Suska, Daniel Filippini (2012)

Angewandte Chemie International Edition , Vol.51 , s.11585-11588 Continue to DOI

Staff
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