Optical Devices Laboratory

At Optical Devices Laboratory (ODL) we conduct multidisciplinary research on methods and devices for optical chemical sensing. We work on disposable and autonomous lab-on-a-chip (LOC) systems, and optical devices conceived for universal interfacing to readout instruments, such as cell phones.

Our activities entail optics and fluidics design, micro-fabrication including 3D printed optics and LOC, biochemical analysis integration, instrumentation and data processing. 

Optical devices

We investigate optical principles and their integration within disposable LOC devices, with special focus on coupling to cell phone camera readout. Some examples are illustrated above.


Focusing at short distance from the camera surface is crucial to simplify LOC positioning, and not only demands refocusing but also adaptive focusing to support diverse cameras with the same disposable LOC design. One solution was to configure a sessile drop on a controlled surface and to operate it as a disposable varifocal lens.

ODL has also demonstrated a disposable optical coupler that uses cell phone screens as light sources to perform label-free angle resolved surface plasmon resonance (SPR) detection with the phone camera.

3D printed integrated optics allow us to configure disposable LOCs for universal coupling to cell phone cameras, using our unibody-LOC (ULOC) technology.

LOC systems

At ODL we develop low-cost fast-prototyping alternatives to classical LOC fabrication of PDMS on glass devices. Replacing costly SU-8 templates by versatile stereolithography (SLA) 3D printed templates we are able to produce prototypes for ~0.5 US$, with unlimited number of 3D features for the same cost and at typically 20 min/prototype.

Further simplification can be achieved by transferring all complex fabrication tasks to the 3D printer and collecting all functional features in a single monolithic printout (unibody-LOC, ULOC), which hosts functionalization, transport and actuation features.

Low surface roughness, achievable with SLA printers, enables fabrication of arbitrarily long and geometrically regular open channels, which can be simply sealed with adhesive tape. Printing times of 10 min permit several optimization cycles/day.

ULOC devices have been configured for paper fluidics and classical LOC formats, can integrate optics, finger pumps and check-valves in entirely disposable configurations.

Publications

2022

Chi Xiao, Jens Eriksson, Anke Suska, Daniel Filippini, Wing Cheung Mak (2022) Print-and-stick unibody microfluidics coupled surface plasmon resonance (SPR) chip for smartphone imaging SPR (Smart-iSRP) Analytica Chimica Acta, Vol. 1201, Article 339606 Continue to DOI

2019

Anke Suska, Daniel Filippini (2019) Autonomous lab-on-a-chip generic architecture for disposables with integrated actuation Scientific Reports, Vol. 9, Article 20320 Continue to DOI

2017

German Comina, Anke Suska, Daniel Filippini (2017) 3D printed disposable optics and lab-on-a-chip devices for chemical sensing with cell phones MICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS XV, Article UNSP 100610E Continue to DOI

2016

German Comina, Anke Suska, Daniel Filippini (2016) Towards autonomous lab-on-a-chip devices for cell phone biosensing Biosensors & bioelectronics, Vol. 77, p. 1153-1167 Continue to DOI
German Comina, Anke Suska, Daniel Filippini (2016) A 3D printed device for quantitative enzymatic detection using cell phones Analytical Methods, Vol. 8, p. 6135-6142 Continue to DOI

2015

German Comina, Anke Suska, Daniel Filippini (2015) Autonomous Chemical Sensing Interface for Universal Cell Phone Readout Angewandte Chemie International Edition, Vol. 54, p. 8708-8712 Continue to DOI

Selected Papers

Cover of publication 'A 3D printed device for quantitative enzymatic detection using cell phones'
German Comina, Anke Suska, Daniel Filippini (2016)

Analytical Methods , Vol.8 , s.6135-6142 Continue to DOI

Cover of publication 'Towards autonomous lab-on-a-chip devices for cell phone biosensing'
German Comina, Anke Suska, Daniel Filippini (2016)

Biosensors & bioelectronics , Vol.77 , s.1153-1167 Continue to DOI

Cover of publication 'Autonomous Chemical Sensing Interface for Universal Cell Phone Readout'
German Comina, Anke Suska, Daniel Filippini (2015)

Angewandte Chemie International Edition , Vol.54 , s.8708-8712 Continue to DOI

Cover of publication 'Low cost lab-on-a-chip prototyping with a consumer grade 3D printer'
German Comina, Anke Suska, Daniel Filippini (2014)

Lab on a Chip , Vol.14 , s.2978-2982 Continue to DOI

Cover of publication 'PDMS lab-on-a-chip fabrication using 3D printed templates'
German Comina, Anke Suska, Daniel Filippini (2014)

Lab on a Chip , Vol.14 , s.424-430 Continue to DOI

Cover of publication 'Biosensing with cell phones'
Pakorn Preechaburana, Anke Suska, Daniel Filippini (2014)

Trends in Biotechnology , Vol.32 , s.351-355 Continue to DOI

Cover of publication 'Surface Plasmon Resonance Chemical Sensing on Cell Phones'
Pakorn Preechaburana, Marcos Gonzalez, Anke Suska, Daniel Filippini (2012)

Angewandte Chemie International Edition , Vol.51 , s.11585-11588 Continue to DOI

Organisation