In December 2018 the national data collection was concluded as 30 000 individuals had been examined. The data is now being merged into a database that will be available for research. In parallel, research analyses of the collected data are already in progress.

Below the scientific articles published so far, where researchers from Linköping have been involved can be found. 


Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women

Magnus Ekström, Josefin Sundh, Anders Andersson, Oskar Angerås, Anders Blomberg, Mats Börjesson, Kenneth Caidahl, Össur Ingi Emilsson, Jan Engvall, Erik Frykholm, Ludger Grote, Kristofer Hedman, Tomas Jernberg, Eva Lindberg, Andrei Malinovschi, André Nyberg, Eric Rullman, Jacob Sandberg, Magnus Sköld, Nikolai Stenfors, Johan Sundström, Hanan Tanash, Suneela Zaigham, Carl-Johan Carlhäll.

DOI: 10.1186/s12931-024-02766-6

Association between cardiovascular risk profile and impaired microvascular function in a Swedish middle-aged cohort (the SCAPIS study)

Sara Bergstrand, Hanna Jonasson, Ingemar Fredriksson, Marcus Larsson, Carl Johan Östgren, Tomas Strömberg. Eur J Prev Cardiol. 2024 Feb 9. PMID: 38333959.

DOI: 10.1093/eurjpc/zwae052


Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications

Gunnar Engström, Erik Lampa, Koen Dekkers, Yi-Ting Lin, Kristin Ahlm, Håkan Ahlström, Joakim Alfredsson, Göran Bergström, Anders Blomberg, John Brandberg, Kenneth Caidahl, Kerstin Cederlund, Olov Duvernoy, Jan E Engvall, Maria J Eriksson, Tove Fall, Bruna Gigante, Anders Gummesson, Emil Hagström, Viktor Hamrefors, Jan Hedner, Magnus Janzon, Tomas Jernberg, Linda Johnson, Lars Lind, Eva Lindberg, Maria Mannila, Ulf Nilsson, Anders Persson, Hans Lennart Persson, Margaretha Persson, Anna Ramnemark, Annika Rosengren, Caroline Schmidt, Linn Skoglund Larsson, C Magnus Sköld, Eva Swahn, Stefan Söderberg, Kjell Torén, Anders Waldenström, Per Wollmer, Suneela Zaigham, Carl Johan Östgren, Johan Sundström. Eur J Epidemiol. 2024 Jan 2. PMID: 38165527

DOI: 10.1007/s10654-023-01088-z

Prevalence and determinants of dilated ascending aorta in a Swedish population: a case–control study

Eva Swahn, Hanna Lekedal, Jan Engvall, Fredrik H Nyström, Lena Jonasson. Eur Heart J Open. 2023 Aug 25;3(5). PMID: 37767013. DOI: 10.1093/ehjopen/oead085

Life’s Essential 8 and Life’s Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project

Ángel Herraiz-Adillo , Sara Higueras-Fresnillo, Viktor H Ahlqvist, Daniel Berglind, Maria B Syrjälä, Bledar Daka, Cecilia Lenander, Johan Sundström, Francisco B Ortega, Carl-Johan Östgren , Karin Rådholm, Pontus Henriksson. Mayo Clin Proc. 2023 Oct 13:S0025-6196(23)00190-8. PMID: 37843486.
DOI: 10.1016/j.mayocp.2023.03.023

Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals-a Swedish population-based study

Carl Johan Östgren, Julia Otten, Karin Festin, Oskar Angerås, Göran Bergström, Kerstin Cederlund, Gunnar Engström, Maria J. Eriksson, Mats Eriksson, Tove Fall, Anders Gummesson, Emil Hagström, Urban Hellman, Stefan K. James, Tomas Jernberg, Johan Kihlberg, David Kylhammar, Hanna Markstad, Peter Nilsson, Anders Persson, Margaretha Persson, Carlo Pirazzi, Rebecka Renklint, Annika Rosengren, Stefan Söderberg, Johan Sundström. Cardiovasc Diabetol. 2023 Sep 27;22(1):261.. PMID: 37759237. DOI: 10.1186/s12933-023-01982-6

Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population

Mårten Sandstedt, Rosanna W S Chung, Camilla Skoglund, Anna K. Lundberg, Carl Johan Östgren, Jan Ernerudh, Lena Jonasson. Immun Ageing. 2023 Aug 31;20(1):45.PMID: 37653480
DOI: 10.1186/s12979-023-00371-7

Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS

Göran Bergström, Annika Rosengren, Elin Bacsovics Brolin, John Brandberg, Kerstin Cederlund, Gunnar Engström, Jan E Engvall, Maria J Eriksson, Isabel Gonçalves, Emil Hagström, Stefan K James, Tomas Jernberg, Mikael Lilja, Martin Magnusson, Anders Persson, Margaretha Persson, Anette Sandström, Caroline Schmidt, Linn Skoglund Larsson, Johan Sundström, Eva Swahn, Stefan Söderberg, Kjell Torén, Carl Johan Östgren, Erik Lampa, Lars Lind. Atherosclerosis. 2023 Feb 3;S0021-9150(23)00051-5. PMID: 36813601 DOI: 10.1016/j.atherosclerosis.2023.01.024

Association Between History of Adverse Pregnancy Outcomes and Coronary Artery Disease Assessed by Coronary Computed Tomography Angiography

Sofia Sederholm Lawesson, Eva Swahn, Mats Pihlsgård, Therese Andersson, Oskar Angerås, Elin Bacsovics Brolin, Ellinor Bergdahl, Marie Blomberg, Christina Christersson, Isabel Gonçalves, Omar Sigurvin Gunnarsson, Tomas Jernberg, Nina Johnston, Karin Leander, Caroline Lilliecreutz, Moa Pehrson, Annika Rosengren, Anette Sandström, Anna Sandström, Giovanna Sarno, Sara Själander, Teresia Svanvik, Erik Thunström, Anna Karin Wikström, Simon Timpka. JAMA.2023 Feb 7;329(5):393-404. PMID: 36749333. DOI: 10.1001/jama.2022.24093

Low prevalence of ideal cardiovascular health in the general Swedish population: Results from the Swedish CArdioPulmonary bioImage Study (SCAPIS)

Sara Higueras-Fresnillo, Ángel Herraiz-Adillo, Viktor H Ahlqvist, Daniel Berglind, Cecilia Lenander, Bledar Daka, Maria Brännholm Syrjälä, Johan Sundström, Carl Johan Östgren, Karin Rådholm, Pontus Henriksson. Scand J Public Health. 2023 Jan 16;14034948221147093. PMID: 36645148. DOI: 10.1177/14034948221147093

Obesity is associated with coronary artery stenosis independently of metabolic risk factors: The population-based SCAPIS study

Lars Lind, Hanna Markstad, Håkan Ahlström, Oskar Angerås, John Brandberg, Mattias Brunström, Gunnar Engström, Jan E. Engvall, Maria J. Eriksson, Mats Eriksson, Anders Gottsäter, Emil Hagström, Benno Krachler, Erik Lampa, Maria Mannila, Peter M. Nilsson, Fredrik H. Nyström, Anders Persson, Björn Redfors, Anette Sandström, Raquel Themudo, Sebastian Völz, Johan Ärnlöv, Carl Johan Östgren and Göran Bergström. Atherosclerosis. 2022 Oct 31;362:1-10. PMID: 36356325. DOI: 10.1016/j.atherosclerosis.2022.10.007

Ectopic fat is associated with cardiac remodeling-A comprehensive assessment of regional fat depots in type 2 diabetes using multi-parametric MRI

Carl Edin, Mattias Ekstedt, Tobias Scheffel, Markus Karlsson, Eva Swahn, Carl Johan Östgren, Jan Engvall, Tino Ebbers, Olof Dahlqvist Leinhard, Peter Lundberg, Carl-Johan Carlhäll. Front Cardiovasc Med. 2022; 9: 813427. PMID: 35966535. DOI: 10.3389/fcvm.2022.813427

Home Blood Pressure Compared With Office Blood Pressure in Relation to Dysglycemia

Peder Af Geijerstam, Jan Engvall, Carl Johan Östgren, Fredrik H Nyström, Karin Rådholm. Am J Hypertens. 2022 Sep 1;35(9):810-819. PMID: 35849046. DOI: 10.1093/ajh/hpac082

Accelerometer derived physical activity patterns in 27.890 middle-aged adults: The SCAPIS cohort study

Elin Ekblom-Bak,Mats Börjesson,Frida Bergman,Göran Bergström,Albin Dahlin-Almevall,Isabel Drake,Gunnar Engström,Jan E Engvall,Anders Gummesson,Emil Hagström,Ola Hjelmgren,Tomas Jernberg,Peter J Johansson,Lars Lind,Maria Mannila,André Nyberg,Margaretha Persson,Christian Reitan,Annika Rosengren,Karin Rådholm,Caroline Schmidt,Magnus C Sköld,Emily Sonestedt,Johan Sundström,Eva Swahn,Jerry Öhlin,Carl Johan Östgren,Örjan Ekblom. Scand J Med Sci Sports. 2022 May;32(5):866-880. PMID: 35080270. DOI: 10.1111/sms.14131

The value of combining individual and small area sociodemographic data for assessing and handling selective participation in cohort studies: Evidence from the Swedish CardioPulmonary bioImage Study

Carl Bonander ,Anton Nilsson,Jonas Björk,Anders Blomberg,Gunnar Engström,Tomas Jernberg,Johan Sundström,Carl Johan Östgren,Göran Bergström,Ulf Strömberg. PLoS One. 2022 Mar 8;17(3):e0265088. PMID: 35259202. DOI: 10.1371/journal.pone.0265088

Association of arterial stiffness with coronary artery calcium score in the general-population: the Swedish CArdioPulmonary bioImage study

Muhammad, Iram Faqir; Engvall, Jan E.; Persson, Margaretha; Borné, Yan; Nilsson, Peter M.; Östgren, Carl Johan; Engström, Gunnar. J Hypertens. 2022 May 1;40(5):933-939. PMID: 35142741. DOI: 10.1097/HJH.0000000000003096

Surveillance of indeterminate pulmonary nodules detected with CT in a Swedish population-based study (SCAPIS): psychosocial consequences and impact on health-related quality of life-a multicentre prospective cross-sectional study

Elisabeth Andersson, Ying Dai Ydrefelt, Marit Johannesson, Maria Lundbäck, Maria Mannila, Margaretha Persson, Eva Swahn, Anetta Bolejko. BMJ Open. 2021 Sep 17;11(9):e048721. PMID: 34535477. DOI: 10.1136/bmjopen-2021-048721

Association of cardiometabolic risk factors with hospitalisation or death due to COVID-19: population-based cohort study in Sweden (SCAPIS)

Per Tornhammar, Tomas Jernberg, Göran Bergström, Anders Blomberg, Gunnar Engström, Jan Engvall, Tove Fall, Magnus Gisslén, Christer Janson, Lars Lind, C Magnus Sköld, Johan Sundström, Stefan Söderberg, Suneela Zaigham, Carl Johan Östgren, Daniel Peter Andersson, Peter Ueda. BMJ Open. 2021 Sep 2;11(9):e051359. PMID: 34475186. DOI: 10.1136/bmjopen-2021-051359

The association between carotid-femoral pulse-wave velocity and lung function in the Swedish CArdioPulmonary bioImage study (SCAPIS) cohort

Suneela Zaigham, Carl-Johan Östgren, Margaretha Persson, Iram Faqir Muhammad, Peter M Nilsson, Per Wollmer, Jan Engvall, Gunnar Engström. Respir Med. 2021 Aug-Sep;185:106504. PMID: 34139577. DOI: 10.1016/j.rmed.2021.106504

Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population

Bergström G., Persson M., Adiels M. et al. doi:

Post-ischemic skin peak oxygen saturation is associated with cardiovascular risk factors: a Swedish cohort study.

Jonasson H, Bergstrand S, Fredriksson I, Larsson M, Östgren CJ, Strömberg T. Microvasc Res. 2021 Nov 23:104284. doi: 10.1016/j.mvr.2021.104284. Epub ahead of print.PMID: 34826433. Doi: 10.1016/j.mvr.2021.104284

Elevated levels of cortisol in hair precede acute myocardial infarction

Tomas Faresjö, Susanna Strömberg, Mike Jones, Andreas Stomby, Jan-Erik Karlsson, Carl Johan Östgren, Åshild Faresjö & Elvar Theodorsson. Sci Rep 10, 22456 (2020). doi:

Automated segmentation of the individual branches of the carotid arteries in contrast-enhanced MR angiography using DeepMedic

Ziegler, M., Alfraeus, J., Bustamante, M. et al. Automated segmentation of the individual branches of the carotid arteries in contrast-enhanced MR angiography using DeepMedic. BMC Med Imaging 21, 38 (2021). doi:

Relationships between cardiovascular risk factors and white-coat hypertension diagnosed by home blood pressure recordings in a middle-aged population.

Johansson MAK, Östgren CJ, Engvall J, Swahn E, Wijkman M, Nystrom FH. J Hypertens. 2021 May 10. doi: 10.1097/HJH.0000000000002888. Epub ahead of print. PMID: 33973957. doi: 10.1097/HJH.0000000000002888

Chronic airflow limitation and its relation to respiratory symptoms among ever-smokers and never-smokers: a cross-sectional study.

Toren K, Schiöler L, Lindberg A, Andersson A, Behndig AF, Bergström G, Blomberg A, Caidahl K, Engvall J, Eriksson M, Hamrefors V, Janson C, Kylhammar D, Lindberg E, Lindén A, Malinovschi A, Persson HL, Sandelin M, Eriksson Ström J, Tanash HA, Vikgren J, Östgren CJ, Wollmer P, Sköld CM. BMJ Open Respir Res. 2020;7(1):e000600. doi: 10.1136/bmjresp-2020-000600

Assessment of Global Lung Function Initiative (GLI) reference equations for diffusing capacity in relation to respiratory burden in the Swedish CArdioPulmonary BioImage Study (SCAPIS)

Malinovschi A, Zhou X, Bake B, Bergström G, Blomberg A, Brisman J, Caidahl K, Engström G, Eriksson MJ, Frølich A, Janson C, Jansson K, Vikgren J, Lindberg A, Linder R, Mannila M, Persson HL, Sköld CM, Torén K, Östgren CJ, Wollmer P, Engvall JE. Eur Respir J. 2020 Apr 27. pii: 1901995. doi: 10.1183/13993003.01995-2019

Exploring the Relationships Between Hemodynamic Stresses in the Carotid Arteries

Magnus Ziegler, Jesper Alfraeus, Elin Good, Jan Engvall, Ebo de Muinck and Petter Dyverfeldt. Front. Cardiovasc. Med., 03 February 2021 doi:

Normative data and the influence of age and sex on microcirculatory function in a middle-aged cohort: results from the SCAPIS study

Jonasson H, Bergstrand S, Fredriksson I, Larsson M, Östgren CJ, Strömberg T. Am J Physiol Heart Circ Physiol. 2020 Apr 1;318(4):H908-H915. doi: 10.1152/ajpheart.00668.2019

Weight gain and blood pressure

Sundström J, Lind L, Lampa E, Angerås O, Bachus E, Bergström G, Carlberg B, Engström G, Engvall JE, Eriksson M, Gigante B, Hagström E, Hjelmgren O, Jansson JH, Jernberg T, Mannila M, Nyström FH, Oldgren J, Persson M, Sandström A, Swahn E, Söderberg S, Torén K, Östgren CJ, Rosengren A. J Hypertens. 2020 Mar;38(3):387-394. doi: 10.1097/HJH.0000000000002298

Towards automated quantification of vessel wall composition using MRI

Ziegler M, Good E, Engvall J, Warntjes M, de Muinck E, Dyverfeldt P. J Magn Reson Imaging. 2020 Mar 10. doi: 10.1002/jmri.27116

Systematic Coronary Risk Evaluation estimated risk and prevalent subclinical atherosclerosis in coronary and carotid arteries: A population-based cohort analysis from the Swedish Cardiopulmonary Bioimage Study

Carl Johan Östgren, Stefan Soderberg, Karin Festin, Oskar Angeras, Goran Bergstrom, Anders Blomberg, John Brandberg, Kerstin Cederlund, Mats Eliasson, Gunnar Engstrom, David Erlinge, Erika Fagman, Emil Hagstrom, Lars Lind, Maria Mannila, Ulf Nilsson, Jonas Oldgren, Ellen Ostenfeld, Anders Persson, Jonas Persson, Margaretha Persson, Annika Rosengren, Johan Sundstrom, Eva Swahn, Jan Engvall, Tomas Jernberg. Eur J Prev Cardiol. 2020 Mar 3. doi: 10.1177/2047487320909300

The association of body mass index, weight gain and central obesity with activity-related breathlessness: the Swedish Cardiopulmonary Bioimage Study

Magnus Pär Ekstrom, Anders Blomberg, Göran Bergström, John Brandberg, Kenneth Caidahl, Gunnar Engström, Jan Engvall, Maria Eriksson, Klas Gränsbo, Tomas Hansen, Tomas Jernberg, Lars Nilsson, Ulf Nilsson, Anna-Carin Olin, Lennart Persson, Annika Rosengren, Martin Sandelin, Magnus Sköld, Johan Sundström, Eva Swahn, Stefan Söderberg, Hanan A. Tanash, Kjell Torén, Carl Johan Östgren, Eva Lindberg. Thorax. 2019 Oct;74(10):958-964. doi: 10.1136/thoraxjnl-2019-213349

The Swedish CArdioPulmonary BioImage Study: objectives and design

G Bergström, G Berglund, A Blomberg, J Brandberg, G Engström, Jan Engvall, M Eriksson, U de Faire, A Flinck, M G Hansson, B Hedblad, O Hjelmgren, C Janson, T Jernberg, Å Johnsson, L Johansson, L Lind, C-G Löfdahl, O Melander, Carl Johan Östgren, Anders Persson, M Persson, A Sandström, C Schmidt, S Söderberg, J Sundström, K Toren, A Waldenström, H Wedel, J Vikgren, B Fagerberg, A Rosengren. J Intern Med. 2015 Dec;278(6):645-59. doi: 10.1111/joim.12384