SCAPIS - the largest cardiovascular and pulmonary research program in Sweden

CT scanner at SCAPIS
CT scan is part of the SCAPIS collection of data

The Swedish Cardiopulmonary Bioimage Study (SCAPIS) combines the use of new imagine technologies, advances in large-scale 'comics' and epidemiological analyses to extensively characterize a Swedish cohort of 30 000 men and women aged between 50 and 64 years.

Aim

The information obtained will be used to improve risk prediction of cardiopulmonary diseases and optimize the ability to study disease mechanisms.

Collection of data

Subjects are recruited and examinations performed at six Swedish university hospitals (Gothenburg, Linköping, Malmö/Lund, Stockholm, Umeå and Uppsala), each site recruiting 5000 individuals from the respective municipality areas.

Since October 1st 2015 Linköping University Hospital is currently recruiting study participants to the SCAPIS cohort and Carl Johan Östgren has the role of principal investigator (PI) at Linköping University.

The SCAPIS core baseline investigation comprises:

  • Questionnaire
  • Fasting blood spot urine samples stored in a biobank
  • Anthropometric data 
  • Office blood pressure recordings
  • Accelerometer data (7 days)
  • Electrocardiogram
  • Carotid ultrasonography
  • Dynamic spirometry
  • Imaging carotid arteries with ultrasound and MRI
  • CT is used to image epicardial, subcutaneous, intra-abdominal, intramuscular and intrahepatic fat deposits.
  • Imaging with CT of the heart for measuring the total coronary artery calcification score (CACS)
  • Coronary CT angiography is performed to assess lumen obstruction caused by plaques. The morphology of calcified and noncalcified plaques as well as remodelling of lumen geometry can be assessed.

Optional additional investigations performed at Linköping University Hospital

  • Home blood pressure recordings
  • Echocardiography
  • Tonometri (SphygmoCor®) for pulse wave analyses and pulse wave velocity
  • Microcirculation is studied with a state-of-the-art method for skin perfusion by use of Doppler Flowmetry and Diffuse Reflectance Spectroscopy
  • CT thorax of the lung during expiration phase
  • Extended MRI- and ultrasonography-based quantification of carotid atherosclerosis with plaque >1.5 mm thickness
  • Measuring prolonged stress exposure by cortisol levels in hair
  • Addition to questionnaire: cognitive function, pain, menopaus

Future morbidity and mortality

Participants will be monitored for future events through annual extensive register searches by linking the unique Swedish PINs to the Swedish National Hospital Discharge Register and the Swedish Cause of Death Register.

Further reading

  • Bergström G, Berglund G, Blomberg A, Brandberg J, Engström G, Engvall J, Eriksson M, de Faire U, Flinck A, Hansson MG, Hedblad B, Hjelmgren O, Janson C, Jernberg T, Johnsson Å, Johansson L, Lind L, Löfdahl CG, Melander O, Östgren CJ, Persson A, Persson M, Sandström A, Schmidt C, Söderberg S, Sundström J, Toren K, Waldenström A, Wedel H, Vikgren J, Fagerberg B, Rosengren A. The Swedish CArdioPulmonary BioImage Study: objectives and design. J Intern Med. 2015 Jun 19. doi: 10.1111/joim.12384. [Epub ahead of print]

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