Alexandra Ahlner

Principal Research Engineer, Docent

Publications

2026

Johanna Hultman, Vivian Morad, Eliane Tanner, Tristan M. G. Kenney, Zuzanna Pietras, Lalit Pramod Khare, Dean Derbyshire, Diana Resetca, Cheryl H. Arrowsmith, Daniel Aili, Simon Ekstrom, Linda Z. Penn, Björn Wallner, Alexandra Ahlner, Maria Sunnerhagen (2026)

The N-Myc MB0-MBI region interacts specifically and dynamically with the N-lobe of Aurora kinase A Nature Communications, Vol. 17, Article 2016 (Article in journal)

https://dx.doi.org/10.1038/s41467-026-69725-1

2025

Johannes Salomonsson, Linda Sjöstrand, Arvid Eskilson, Dean Derbyshire, Padraig D´arcy, Maria Sunnerhagen, Alexandra Ahlner (2025)

Dynamic networks connect the USP14 active site region with the proteasome interaction surface Protein Science, Vol. 34, Article e70077 (Article in journal)

https://dx.doi.org/10.1002/pro.70077

2024

Johannes Salomonsson, Björn Wallner, Linda Sjöstrand, Padraig D´arcy, Maria Sunnerhagen, Alexandra Ahlner (2024)

Transient interdomain interactions in free USP14 shape its conformational ensemble Protein Science, Vol. 33, Article e4975 (Article in journal)

https://dx.doi.org/10.1002/pro.4975

2022

Yong Wei, Cornelia Redel, Alexandra Ahlner, Alexander Lemak, Isak Johansson-Åkhe, Scott Houliston, Tristan M. G. Kenney, Aaliya Tamachi, Vivian Morad, Shili Duan, David W. Andrews, Björn Wallner, Maria Sunnerhagen, Cheryl H. Arrowsmith, Linda Z. Penn (2022)

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase Nucleic Acids Research, Vol. 50, p. 3505-3522 (Article in journal)

https://dx.doi.org/10.1093/nar/gkac138

2019

Yong Wei, Diana Resetca, Zhe Li, Isak Johansson-Åkhe, Alexandra Ahlner, Sara Helander, Amélie Wallenhammar, Vivian Morad, Brian Raught, Björn Wallner, Tetsuro Kokubo, Yufeng Tong, Linda Z. Penn, Maria Sunnerhagen (2019)

Multiple direct interactions of TBP with the MYC oncoprotein Nature Structural & Molecular Biology, Vol. 26, p. 1035-+ (Article in journal)

https://dx.doi.org/10.1038/s41594-019-0321-z

Research

ProLinC

PROtein folding and Ligand INteraction Core facility (ProLinC) at Linköping University.

News

Chemists aim to disrupt cancer-related protein

How can we understand a protein when it is never still, but constantly changes shape? This is one of the challenges for LiU researchers who are studying the cancer-related protein MYC.

Elusive cancer-related protein captured in flight

Scientists have for the first time seen how the MYC protein, which plays a central role in cancer, binds to a key protein and controls important functions in cells. The new discovery may in the long term help in the development of new cancer drugs.

Organisation

Chemistry (KEMI)

The division's research is being performed in the areas of biochemistry, molecular biotechnology, organic chemistry, analytical chemistry, chemical engineering, inorganic chemistry and in physical chemistry, especially computational chemistry.

Person with transmission electron microscope.

Department of Physics, Chemistry and Biology (IFM)

Excellent undergraduate teaching and research in the areas of biology, chemistry, materials and applied physics and theory and modelling are conducted at this department.