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Alexandra Ahlner

Principal Research Engineer

Publications

2024

Johannes Salomonsson, Björn Wallner, Linda Sjöstrand, Padraig D´arcy, Maria Sunnerhagen, Alexandra Ahlner (2024) Transient interdomain interactions in free USP14 shape its conformational ensemble Protein Science, Vol. 33, Article e4975 (Article in journal) Continue to DOI

2022

Yong Wei, Cornelia Redel, Alexandra Ahlner, Alexander Lemak, Isak Johansson-Åkhe, Scott Houliston, Tristan M. G. Kenney, Aaliya Tamachi, Vivian Morad, Shili Duan, David W. Andrews, Björn Wallner, Maria Sunnerhagen, Cheryl H. Arrowsmith, Linda Z. Penn (2022) The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase Nucleic Acids Research, Vol. 50, p. 3505-3522 (Article in journal) Continue to DOI

2019

Yong Wei, Diana Resetca, Zhe Li, Isak Johansson-Åkhe, Alexandra Ahlner, Sara Helander, Amélie Wallenhammar, Vivian Morad, Brian Raught, Björn Wallner, Tetsuro Kokubo, Yufeng Tong, Linda Z. Penn, Maria Sunnerhagen (2019) Multiple direct interactions of TBP with the MYC oncoprotein Nature Structural & Molecular Biology, Vol. 26, p. 1035-+ (Article in journal) Continue to DOI
Madhanagopal Anandapadamanaban, Nikolaos C. Kyriakidis, Veronika Csizmok, Amélie Wallenhammar, Alexander C. Espinosa, Alexandra Ahlner, Adam R. Round, Jill Trewhella, Martin Moche, Marie Wahren-Herlenius, Maria Sunnerhagen (2019) E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2 Journal of Biological Chemistry, Vol. 294, p. 11404-11419 (Article in journal) Continue to DOI
Karthik Selvaraj, Arjan Mofers, Paola Pellegrini, Johannes Salomonsson, Alexandra Ahlner, Vivian Morad, Ellin-Kristina Hillert, Belen Espinosa, Elias S. J. Arner, Lasse Jensen, Jonas Malmstrom, Maria V Turkina, Padraig D´arcy, Michael A. Walters, Maria Sunnerhagen, Stig Linder (2019) Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system Scientific Reports, Vol. 9, Article 9841 (Article in journal) Continue to DOI

Research

researcher in a ProLinC lab

ProLinC

PROtein folding and Ligand INteraction Core facility (ProLinC) at Linköping University.
pipettering ur litet provrör

Chemistry

Life is chemistry. Research into all principal fields of chemistry is conducted at LiU, including materials science and the study of biological molecules.

News

Alexandra Ahlner prepares an NMR-test.

Chemists aim to disrupt cancer-related protein

How can we understand a protein when it is never still, but constantly changes shape? This is one of the challenges for LiU researchers who are studying the cancer-related protein MYC.

Elusive cancer-related protein captured in flight

Scientists have for the first time seen how the MYC protein, which plays a central role in cancer, binds to a key protein and controls important functions in cells. The new discovery may in the long term help in the development of new cancer drugs.

Organisation

Chemistry (KEMI)

The division's research is being performed in the areas of biochemistry, molecular biotechnology, organic chemistry, analytical chemistry, chemical engineering, inorganic chemistry and in physical chemistry, especially computational chemistry.

Department of Physics, Chemistry and Biology (IFM)

Undergraduate teaching and research in the areas of biology, chemistry, materials and applied physics and theory and modelling are conducted at this department.

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