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Amanda Welin

Docent and associated clinical WCMM fellow with a focus on optimized laboratory diagnostics

Novel clinical applications of imaging flow cytometry

My group's research aims to solve clinical problems through improved laboratory diagnostics. We use imaging flow cytometry - a technique combining flow cytometry and fluorescence microscopy - as our main tool, enabling quantitative morphological analysis of thousands of cells in flow. The technique is applied to blood samples from different patient groups where there is a clinical need for faster, more objective diagnostics or detailed information about cell populations and their interactions.

I'm a resident physician in clinical chemistry at Region Östergötland and since 2015 associate professor in medical microbiology. In my doctoral work I studied mycobacterial survival mechanisms inside innate immune cells. After defending my thesis at LiU in 2011, I did a postdoc at the Sahlgrenska Academy focusing on human neutrophil subpopulations, followed by a postdoc at the University of Zürich funded by the Swedish Research Council, where I used an amoeba model to study intracellular bacterial infections. In 2019 I returned to Linköping University as a principal investigator, in recent years combined with clinical work, and I was appointed an associated clinical WCMM fellow in 2025.

Publications

2025

Srikanth Mairpady Shambat, Puran Chen, Rocky M Barilla, Markus Huemer, Johanna Snäll, Amanda Welin, Taylor S Cohen, Virginia Takahashi, Samuel B Berry, Alejandro Gómez-Mejia, Tiziano A Schweizer, Danen M Cunoosamy, Sara Cajander, Magda Lourda, Volkan Özenci, Ewerton Marques Maggio, Reto A Schüpbach, Kristoffer Strålin, Annelies S Zinkernagel, Anna Norrby-Teglund, Mattias Svensson (2025) Alpha-toxin-elicited CX3CL1 release in Staphylococcus aureus pneumonia impairs bactericidal function of human monocytes. mBio, p. e0268925-, Article e0268925 (Article in journal) Continue to DOI

2023

Amanda Welin, Dario Hüsler, Hubert Hilbi (2023) Imaging Flow Cytometry of Legionella-Containing Vacuoles in Intact and Homogenized Wild-Type and Mutant Dictyostelium Spectral and Imaging Cytometry: Methods and Protocols, p. 63-85 (Chapter in book) Continue to DOI
Hans Lundquist, Henrik Andersson, Michelle S Chew, Jyotirmoy Das, Maria V Turkina, Amanda Welin (2023) The Olfactomedin-4-Defined Human Neutrophil Subsets Differ in Proteomic Profile in Healthy Individuals and Patients with Septic Shock Journal of Innate Immunity, Vol. 15, p. 351-364 (Article in journal) Continue to DOI
Vignesh Venkatakrishnan, Jonas Elmwall, Trisha Lahiri, Martina Sundqvist, Linda Bergqvist, Hakon Leffler, Ulf J. Nilsson, Amanda Welin, Johan Bylund, Anna Karlsson-Bengtsson (2023) Novel inhibitory effect of galectin-3 on the respiratory burst induced by Staphylococcus aureus in human neutrophils Glycobiology, Vol. 33, p. 503-511 (Article in journal) Continue to DOI
Martina Sundqvist, Karin Christenson, Per Wekell, Halla Bjornsdottir, Agnes Dahlstrand Rudin, Felix P. Sanchez Klose, Tilmann Kallinich, Amanda Welin, Lena Bjorkman, Johan Bylund, Anna Karlsson-Bengtsson, Stefan Berg (2023) Severe chronic non-bacterial osteomyelitis in combination with total MPO deficiency and responsiveness to TNFa inhibition Frontiers in Immunology, Vol. 14, Article 1233101 (Article in journal) Continue to DOI

Organisation