Angela Dello Stritto

Postdoc

Publications

2025

Elena Faustini, Angela Dello Stritto, Andrea Panza, Ylli Doksani, Francisca Lottersberger (2025)

Nuclear deformability increases PARPi sensitivity in BRCA1-deficient cells by increasing microtubule-dependent DNA break mobility Nature Communications, Vol. 16, Article 5326 (Article in journal)

https://dx.doi.org/10.1038/s41467-025-60756-8

News

The shape of the cell nucleus influences cancer treatment

Cancer cells with a cell nucleus that is easily deformed are more sensitive to drugs that damage DNA, shows a new study. The results may also explain why combining certain cancer drugs can produce the opposite of the intended effect.

Female researcher working with cells in a lab.

New discovery reveals how chromosome ends can be protected

Researchers have uncovered a previously unknown mechanism that safeguards the chromosome ends from being mistakenly repaired by the cell - a mistake with potentially catastrophic outcomes.