Photo of Åsa Keita

Åsa Keita

Senior Associate Professor

Associate professor in Experimental gastroenterology.
My research involves studying the interactions between the enteric nervous system, immune
cells and the barrier function and studying the connection between the gut, its gut flora and the brain.

Research on IBS and IBD

Studies of neuro-immune interactions and regulation of barrier function in IBS and inflammatory bowel disease, IBD.

The intestine is continuously exposed to different substances, either via the food or the microbiota. The ability to allow absorption of nutrients and fluids but simultaneously prevent harmful substances from passing through the epithelium is defined as intestinal barrier function. Research from my group and others has shown that patients with IBS and IBD have a disturbed barrier function with an increased passage of bacteria and other harmful substances. IBS is a chronic functional intestinal disorder characterised by diarrhea constipation and pain, often combined with fatigue and depression. IBD is a chronic intestinal disease, which in contrast to IBS, includes an inflammation of the intestinal mucosa. IBD is associated with abdominal pain, diarrhea and weight loss.

My research focuses on studies of the mucosal interactions involving immune cells, such as mast cells, eosinophils and the enteric glial cells, and the enteric nervous system. Among others, I have focused on the neuropeptide VIP, which has shown to be involved in the regulation of the intestinal barrier in both IBS and IBD. Further, I aim to connect the gut findings with measurements of the brain, and in addition try to connect this to the patient´s own microbiota.

MIIC Postdoctoral program

Medical Inflammation and Infection Center is seeking postdoctoral fellows

Post doc project: “The roles of Enteric glial cells in patients with irritable bowel syndrome and inactive ulcerative colitis”

In this project we aim to study the importance of enteric glial cells (EGC) and their roles in intestinal barrier function and interaction with immune cells, nerves and bacteria in patients with irritable bowel syndrome (IBS) and patients with inactive ulcerative colitis (UC).

Since the project involves isolation of cells from intestinal tissues and cell culturing, the applicant should have experience from working with in vitro cell culture methodologies. Moreover, applicant should have knowledge in immunofluorescence and fluorescence/confocal microscopy as well as Western blot technique. A knowledge in gastroenterology, neuro-immune interactions of the gut and intestinal permeability is meriting.



Beatrice Zitti, Elena Hoffer, Wenning Zheng, Ram Vinay Pandey, Heinrich Schlums, Giovanna Perinetti Casoni, Irene Fusi, Lien Nguyen, Jaanika Karner, Efthymia Kokkinou, Anna Carrasco, Jessica Gahm, Marcus Ehrstrom, Staffan Happaniemi, Åsa Keita, Charlotte R. H. Hedin, Jenny Mjosberg, Liv Eidsmo, Yenan T. Bryceson (2023) Human skin-resident CD8+T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a Immunity, Vol. 56, p. 1285-1302.e7 Continue to DOI
Linda Gerdin, Ana M. Gonzalez-Castro, Ann-Charlott Ericson, Mats Persborn, Javier Santos, Susanna Walter, Åsa Keita, Maria Vicario, Johan D Söderholm (2023) Acute psychological stress increases paracellular permeability and modulates immune activity in rectal mucosa of healthy volunteers United European Gastroenterology journal, Vol. 11, p. 31-41 Continue to DOI


Olga Bednarska, Olga Biskou, Hans Israelsen, Martin Tinnerfelt Winberg, Susanna Walter, Åsa Keita (2022) A postbiotic fermented oat gruel may have a beneficial effect on the colonic mucosal barrier in patients with irritable bowel syndrome Frontiers in Nutrition, Vol. 9, Article 1004084 Continue to DOI
Patrik Lundquist, Georgiy Khodus, Zhigao Niu, Lungile Nomcebo Thwala, Fiona McCartney, Ivailo Simoff, Ellen Andersson, Ana Beloqui, Aloise Mabondzo, Sandra Robla, Dominic-Luc Webb, Per M. Hellstroem, Åsa Keita, Eduardo Sima, Noemi Csaba, Magnus Sundbom, Veronique Preat, David J. Brayden, Maria Jose Alonso, Per Artursson (2022) Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat ACS Nano, Vol. 16, p. 14210-14229 Continue to DOI
Luiza Moraes Holst, Jonas Halfvarson, Marie Carlson, Charlotte Hedin, Robert Kruse, Carl Mårten Lindqvist, Daniel Bergemalm, Sven Almér, Francesca Bresso, Maria Ling Lundström, Dirk Repsilber, Mauro D'Amato, Åsa Keita, Henrik Hjortswang, Johan D Söderholm, Johanna Sundin, Hans Törnblom, Magnus Simrén, Hans Strid, Maria K. Magnusson, Lena Öhman (2022) Downregulated Mucosal Autophagy, Alpha Kinase-1 and IL-17 Signaling Pathways in Active and Quiescent Ulcerative Colitis Clinical and Experimental Gastroenterology, Vol. 15, p. 129-144 Continue to DOI