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Bergthor Björnsson

Tumor diseases of the liver and pancreas create great suffering for both patients and relatives. The overall goal of my research is to improve the care of this patient group.

Liver and pancreatic tumors

The research I conduct is largely based on collaborations in various networks. After my defense in 2014, I ran a randomized trial at US where the value of minimally invasive pancreatic surgery was evaluated. At the same time, our unit led a multicenter and multinational study comparing different liver surgeries. It became clear that to tackle the larger clinical issues, large networks are needed. Therefore, I participate in the research for clinical projects described below.

Translational research often requires closer collaboration than clinical research and there can be difficulties with large distances. Therefore, the translational part of my research is mainly conducted in collaboration with other researchers at LiU.

Publications

2024

Tess M. E. van Ramshorst, Jony van Hilst, Ugo Boggi, Safi Dokmak, Bjorn Edwin, Tobias Keck, Igor Khatkov, Alberto Balduzzi, Alessandra Pulvirenti, Jawad Ahmad, Hani Al Saati, Adnan Alseidi, Fabio Ausania, Juan S. Azagra, Gianpaolo Balzano, Bergthor Björnsson, Fatih M. Can, Umberto Cillo, Mathieu D'Hondt, Mikhail Efanov, Mert Erkan, Francisco Espin Alvarez, Alessandro Esposito, Giovanni Ferrari, Bas Groot Koerkamp, Andrew A. Gumbs, Melissa E. Hogg, Benedetto Ielpo, Arpad Ivanecz, Jin-Young Jang, Dyre Kleive, David A. Kooby, Misha D. P. Luyer, Giovanni Marchegiani, Krishna Menon, I. Quintus Molenaar, Yuichi Nagakawa, Masafumi Nakamura, Diego Palumbo, Tullio Piardi, Jose M. Ramia, Olivier Saint-Marc, George I Salti, Oliver Strobel, Charles M. Vollmer, Alice C. Wei, Steve White, Yoo-Seok Yoon, Alessandro Zerbi, Claudio Bassi, Frederik Berrevoet, Carlos Chan, Felipe J. Coimbra, Kevin C. P. Conlon, Christos Dervenis, Massimo Falconi, Isabella Frigerio, Giuseppe K. Fusai, Michelle L. De Oliveira, Antonio D. Pinna, John N. Primrose, Alain Sauvanet, Alejandro Serrablo, Sameer Smadi, Sergio Alfieri, Stefano Berti, Giovanni Butturini, Riccardo Casadei, Roberto Coppola, Fabrizio Di Benedetto, Giuseppe M. Ettorre, Felice Giuliante, Elio Jovine, Riccardo Memeo, Andrea Pietrabissa, Nazario Portolani, Roberto Salvia, Ajith K. Siriwardena, Horacio J. Asbun, Marc G. Besselink, Mohammad Abu Hilal (2024) Standardizing definitions and terminology of left-sided pancreatic resections through an international Delphi consensus British Journal of Surgery, Vol. 111, Article znae039 Continue to DOI
Bas A. Uijterwijk, Daniel H. Lemmers, Giuseppe Kito Fusai, Alessandro Zerbi, Roberto Salvia, Ernesto Sparrelid, Steven White, Bergthor Björnsson, Vasileios K. Mavroeidis, Keith J. Roberts, Michele Mazzola, Santiago Sanchez Cabus, Zahir Soonawalla, Dimitris Korkolis, Mario Serradilla, Patrick Pessaux, Misha Luyer, Nicholas Mowbray, Benedetto Ielpo, Alessandro Mazzotta, Jorg Kleeff, Ugo Boggi, Miguel Angel Suarez Munoz, Brian K. P. Goh, Elena Andreotti, Hanneke Wilmink, Michele Ghidini, Alberto Zaniboni, Caroline Verbeke, Volkan Adsay, Denise Bianchi, Marc G. Besselink, Mohammed Abu Hilal, International Study Group on Non-Pancreatic Periampullary Cancer (ISGACA) (2024) Differences in Lymph Node Metastases Patterns Among Non-pancreatic Periampullary Cancers and Histologic Subtypes: An International Multicenter Retrospective Cohort Study and Systematic Review Annals of Surgical Oncology Continue to DOI
Knut Jorgen Labori, Svein Olav Bratlie, Bodil Andersson, Jon-Helge Angelsen, Christina Biorserud, Bergthor Björnsson, Erling Audun Bringeland, Nils Elander, Herish Garresori, Jon Erik Gronbech, Johan Haux, Oskar Hemmingsson, Maria Gustafsson Liljefors, Tor Age Myklebust, Linn Save Nymo, Katriina Peltola, Per Pfeiffer, Ville Sallinen, Per Sandström, Ernesto Sparrelid, Helge Stenvold, Kjetil Soreide, Bobby Tingstedt, Caroline Verbeke, Daniel Ohlund, Leif Klint, Svein Dueland, Kristoffer Lassen (2024) Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial The Lancet Gastroenterology & Hepatology, Vol. 9, p. 205-217 Continue to DOI
Bas A. Uijterwijk, Daniel H. Lemmers, Giuseppe Kito Fusai, Bas Groot Koerkamp, Sharnice Koek, Alessandro Zerbi, Ernesto Sparrelid, Ugo Boggi, Misha Luyer, Benedetto Ielpo, Roberto Salvia, Brian K. P. Goh, Geert Kazemier, Bergthor Björnsson, Mario Serradilla-Martin, Michele Mazzola, Vasileios K. Mavroeidis, Santiago Sanchez-Cabus, Patrick Pessaux, Steven White, Adnan Alseidi, Raffaele Dalla Valle, Dimitris Korkolis, Louisa R. Bolm, Zahir Soonawalla, Keith J. Roberts, Miljana Vladimirov, Alessandro Mazzotta, Jorg Kleeff, Miguel Angel Suarez Munoz, Marc G. Besselink, Mohammed Abu Hilal (2024) Different Periampullary Types and Subtypes Leading to Different Perioperative Outcomes of Pancreatoduodenectomy: Reality and Not a Myth; An International Multicenter Cohort Study Cancers, Vol. 16, Article 899 Continue to DOI
Karolina Kristenson, Edvard Gerring, Bergthor Björnsson, Per Sandström, Kristofer Hedman (2024) Peak oxygen uptake in combination with ventilatory efficiency improve risk stratification in major abdominal surgery Physiological Reports, Vol. 12, Article e15904 Continue to DOI

Research

Liver and pancreatic tumors

The research I conduct can be divided into clinical projects and trials where the aim is to improve care for today's patients within a short time and translational projects where the aim is to increase knowledge and understanding of underlying mechanisms.

Clinical projects

In the DRAGON network, we investigate methods to stimulate liver growth with as little intervention as possible. The core of the method being explored is that in addition to embolization of the portal vein, the hepatic vein(s) are also embolized to increase growth of the liver that can be left behind during surgery.

The DIPLOMA studies are about comparing the minimally invasive surgical method for pancreatic tumors with the classic open operations to ensure the introduction and expansion of minimally invasive pancreatic surgery. Within the same area is E-MIPS, the European registry for minimally invasive pancreatic surgery.

The ISGACA collaboration focuses on the management of tumors in the bile duct, its mouth and in the duodenum. A number of retrospective multicenter studies have already been done and the prospective ADAPTA study will investigate the choice of chemotherapy for tumors in the bile duct mouth.

The NorPact collaboration is investigating the value of pretreatment with chemotherapy before surgery for pancreatic cancer. Results of a prospective randomized trial are expected shortly.

In the ScanPan project, which is a Nordic collaboration starting from Linköping, clinical research in liver and pancreas areas meets where the value of treatment in pancreatic cancer that has spread (to the liver) is investigated.

 

Translational projects

Zebrafish embryos are used to investigate tumor characteristics in colon cancer, liver metastases (daughter tumors) and pancreatic cancer. The overall goal of these studies is to be able to provide more targeted chemotherapy based on the individual patient's tumor. The collaboration with basic research is with Lasse Jansen.
The liver's propensity to receive daughter tumors from colon and rectal cancer and pancreatic cancer is investigated in a project run in collaboration with Linda Bojmar.

I am a member of Bojmar Lab

Organisation