Home
Photo of Bergthor Björnsson

Bergthor Björnsson

Adjunct Professor

Tumor diseases of the liver and pancreas create great suffering for both patients and relatives. The overall goal of my research is to improve the care of this patient group.

Liver and pancreatic tumors

The research I conduct is largely based on collaborations in various networks. After my defense in 2014, I ran a randomized trial at US where the value of minimally invasive pancreatic surgery was evaluated. At the same time, our unit led a multicenter and multinational study comparing different liver surgeries. It became clear that to tackle the larger clinical issues, large networks are needed. Therefore, I participate in the research for clinical projects described below.

Translational research often requires closer collaboration than clinical research and there can be difficulties with large distances. Therefore, the translational part of my research is mainly conducted in collaboration with other researchers at LiU.

Publications

2025

Amaia Jauregi Miguel, Simon Söderholm, Tamina Weiss, Anna Nordin, Valeria Ghezzi, Salome M. Brutsch, Pierfrancesco Pagella, Yorick van de Grift, Gianluca Zambanini, Jacopo Ulisse, Alessandro Mattia, Ruslan Deviatiiarov, Elena Faustini, Lavanya Moparthi, Wenjing Zhong, Bergthor Björnsson, Per A Sandström, Erik Lundqvist, Francisca Lottersberger, Stefan Koch, Andreas E. Moor, Xiao-Feng Sun, Eleonore von Castelmur, Guojun Shengo, Claudio Cantù (2025) The developmental factor TBX3 engages with the Wnt/ß-catenin transcriptional complex in colorectal cancer to regulate metastasis genes Proceedings of the National Academy of Sciences of the United States of America, Vol. 122, Article 2419691122 (Article in journal) Continue to DOI
Anna Lindhoff Larsson, Peter Holka, Bengt Isaksson, Oskar Hemmingsson, Per Sandström, Bergthor Björnsson (2025) Translation and validation of the Swedish version of the EORTC LMC-21, the disease-specific questionnaire for assessing health-related quality of life in patients with colorectal liver metastases BMC Gastroenterology, Vol. 25, Article 281 (Article in journal) Continue to DOI
Remon Korenblik, Sinead James, Jens Smits, Rafael Diaz-Nieto, Rob Davis, Benjamin K. Y. Chan, Joris I. Erdmann, IJsbrand A. J. Zijlstra, Pieter J. W. Arntz, Otto Kollmar, Martin H. Hoffmann, David G. Vass, Richard Lindsay, Matteo Serenari, Alberto Cappelli, Paul D. Gobardhan, Farshad Imani, Yiliam Fundora Suarez, Fernando Gomez Munos, Dirk J. Grunhagen, Adriaan Moelker, Kay J. Pieterman, Joerg Kleeff, Walter A. Wohlgemuth, Eric Herrero, Arantxa Gelabert, Stefan Breitenstein, Nico Seeger, Olivier Detry, Laurent Gerard, Per Sandström, Bergthor Björnsson, Luca A. Aldrighetti, Francesco De Cobelli, Wouter K. G. Leclercq, Laurens J. van Baardewijk, Daniel Croagh, Diederick W. De Boo, T. Peter Kingham, Fourat Ridouani, Peter Metrakos, David Valenti, Jennifer Kalil, Asmund A. Fretland, Ulrik Carling, Guillaume Martel, Stephen Ryan, Venkatesha Udupa, Andrew Macdonald, Jordan C. Tasse, Gregor A. Stavrou, Elmar Spuentrup, Francisco G. Borobia, Eva Criado, Ernesto Sparrelid, Martin Delle, Jordi Navines-Lopez, Jaume Sampere Moragues, Esteban Cugat Andorra, Andreas Schnitzbauer, Thomas J. Vogl, Jan Heil, John N. Primrose, Sachin Modi, Suomi M. G. Fouraschen, Reinoud P. H. Bokkers, Marieke T. de Boer, Inne H. M. Borel Rinkes, Maarten L. J. Smits, Thomas Gruenberger, Ivan Baclija, Kevin G. Billingsley, David C. Madoff, Alejandro Serrablo, Luis Sarria, Xiaoying Wang, Xudong Qu, Bjorn Winkens, Steven W. L. Olde Damink, Marc H. A. Bemelmans, Maxime J. L. Dewulf, Christoph A. Binkert, Erik Schadde, Christiaan van der Leij, Ronald M. van Dam (2025) Safety and efficacy of combined portal and hepatic vein embolisation in patients with colorectal liver metastases (DRAGON1): a multicentre, single-arm clinical trial The Lancet Regional Health: Europe, Vol. 53, Article 101284 (Article in journal) Continue to DOI
Hakon Blomstrand, Erik Tesselaar, Bergthor Björnsson, Wolf Bartholomä, Tomas Bjerner, Michael Sandborg, Nils Elander, Mischa Woisetschläger (2025) PCD-CT Versus EID-CT in Imaging of Pancreatic Ductal Adenocarcinoma: A Prospective Comparative Pilot Study Anticancer Research, Vol. 45, p. 1547-1558 (Article in journal) Continue to DOI
Bas A. Uijterwijk, Alma Moekotte, Ugo Boggi, Michele Mazzola, Bas Groot Koerkamp, Raffaele Dalle Valle, Sharnice Koek, Louisa Bolm, Alessandro Mazzotta, Misha Luyer, Brian K. P. Goh, Miguel A. Suarez Munoz, Bergthor Björnsson, Geert Kazemier, Benedetto Ielpo, Patrick Pessaux, Jorg Kleeff, Poya Ghorbani, Vasileios K. Mavroeidis, Giuseppe K. Fusai, Roberto Salvia, Alessandro Zerbi, Keith J. Roberts, Adnan Alseidi, Bilal Al-Sarireh, Mario Serradilla-Martin, Miljana Vladimirov, Dimitris Korkolis, Zahir Soonawalla, Mario Gruppo, Stefan A. W. Bouwense, Charles M. Vollmer, Stephen W. Behrman, John D. Christein, Marc G. Besselink, Mohammed Abu Hilal (2025) Oncological resection and perioperative outcomes of robotic, laparoscopic and open pancreatoduodenectomy for ampullary adenocarcinoma: a propensity score matched international multicenter cohort study HPB, Vol. 27, p. 318-329 (Article in journal) Continue to DOI

Research

Liver and pancreatic tumors

The research I conduct can be divided into clinical projects and trials where the aim is to improve care for today's patients within a short time and translational projects where the aim is to increase knowledge and understanding of underlying mechanisms.

Clinical projects

In the DRAGON network, we investigate methods to stimulate liver growth with as little intervention as possible. The core of the method being explored is that in addition to embolization of the portal vein, the hepatic vein(s) are also embolized to increase growth of the liver that can be left behind during surgery.

The DIPLOMA studies are about comparing the minimally invasive surgical method for pancreatic tumors with the classic open operations to ensure the introduction and expansion of minimally invasive pancreatic surgery. Within the same area is E-MIPS, the European registry for minimally invasive pancreatic surgery.

The ISGACA collaboration focuses on the management of tumors in the bile duct, its mouth and in the duodenum. A number of retrospective multicenter studies have already been done and the prospective ADAPTA study will investigate the choice of chemotherapy for tumors in the bile duct mouth.

The NorPact collaboration is investigating the value of pretreatment with chemotherapy before surgery for pancreatic cancer. Results of a prospective randomized trial are expected shortly.

In the ScanPan project, which is a Nordic collaboration starting from Linköping, clinical research in liver and pancreas areas meets where the value of treatment in pancreatic cancer that has spread (to the liver) is investigated.

Translational projects

Zebrafish embryos are used to investigate tumor characteristics in colon cancer, liver metastases (daughter tumors) and pancreatic cancer. The overall goal of these studies is to be able to provide more targeted chemotherapy based on the individual patient's tumor. The collaboration with basic research is with Lasse Jansen.
The liver's propensity to receive daughter tumors from colon and rectal cancer and pancreatic cancer is investigated in a project run in collaboration with Linda Bojmar.

I am a member of Bojmar Lab

A banner with focus on cancer research.

Bojmar Lab

Cancer is a systemic disease. Our research focuses on understanding crosstalk between different organs in the human body, and how this affects cancer progression. We focus mainly on gastrointestinal cancers and their common hepatic metastasis.

Organisation

Teaser image for the division KOO at BKV.

Division of Surgery, Orthopedics and Oncology (KOO)

We carry out research in the fields of experimental orthopedics, surgery and oncology.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

Tags