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Bergthor Björnsson

Tumor diseases of the liver and pancreas create great suffering for both patients and relatives. The overall goal of my research is to improve the care of this patient group.

Liver and pancreatic tumors

The research I conduct is largely based on collaborations in various networks. After my defense in 2014, I ran a randomized trial at US where the value of minimally invasive pancreatic surgery was evaluated. At the same time, our unit led a multicenter and multinational study comparing different liver surgeries. It became clear that to tackle the larger clinical issues, large networks are needed. Therefore, I participate in the research for clinical projects described below.

Translational research often requires closer collaboration than clinical research and there can be difficulties with large distances. Therefore, the translational part of my research is mainly conducted in collaboration with other researchers at LiU.

Publications

2024

Nina Grankvist, Cecilia Jönsson, Karin Hedin, Nicolas Sundqvist, Per Sandström, Bergthor Björnsson, Arjana Begzati, Evgeniya Mickols, Per Artursson, Mohit Jain, Gunnar Cedersund, Roland Nilsson (2024) Global 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo Nature Metabolism (Article in journal) Continue to DOI
Thomas F. Stoop, Simone Augustinus, Bergthor Björnsson, Bobby Tingstedt, Bodil Andersson, Christopher L. Wolfgang, Jens Werner, Karin Johansen, Martijn W. J. Stommel, Matthew H. G. Katz, Michael Ghadimi, Michael G. House, Poya Ghorbani, I. Quintus Molenaar, Roeland F. de Wilde, J. Sven D. Mieog, Tobias Keck, Ulrich F. Wellner, Waldemar Uhl, Marc G. Besselink, Henry A. Pitt, Marco Del Chiaro (2024) Surgical Outcome After Distal Pancreatectomy With and Without Portomesenteric Venous Resection in Patients with Pancreatic Adenocarcinoma: A Transatlantic Evaluation of Patients in North America, Germany, Sweden, and The Netherlands (GAPASURG) Annals of Surgical Oncology (Article in journal) Continue to DOI
Eduard A. van Bodegraven, Tess M. E. van Ramshorst, Svein O. Bratlie, Arto Kokkola, Ernesto Sparrelid, Bergthor Björnsson, Dyre Kleive, Stefan K. Burgdorf, Safi Dokmak, Bas Groot Koerkamp, Santiago Sanchez Cabus, I. Quintus Molenaar, Ugo Boggi, Olivier R. Busch, Miha Petric, Geert Roeyen, Thilo Hackert, Daan J. Lips, Mathieu D'Hondt, Marielle M. E. Coolsen, Giovanni Ferrari, Bobby Tingstedt, Alejandro Serrablo, Sebastien Gaujoux, Marco Ramera, Igor Khatkov, Fabio Ausania, Regis Souche, Sebastiaan Festen, Frederik Berrevoet, Tobias Keck, Robert P. Sutcliffe, Elizabeth Pando, Roeland F. de Wilde, Beatrice Aussilhou, Paul S. Krohn, Bjorn Edwin, Per Sandström, Stefan Gilg, Hanna Seppanen, Caroline Vilhav, Mohammad Abu Hilal, Marc G. Besselink (2024) Minimally invasive robot-assisted and laparoscopic distal pancreatectomy in a pan-European registry a retrospective cohort study International Journal of Surgery, Vol. 110, p. 3554-3561 (Article in journal) Continue to DOI
Bas A. Uijterwijk, Daniel H. Lemmers, Michele Ghidini, Hanneke Wilmink, Alberto Zaniboni, Roberto Salvia, Giuseppe Kito Fusai, Bas Groot Koerkamp, Sharnice Koek, Poya Ghorbani, Alessandro Zerbi, Gennaro Nappo, Misha Luyer, Brian K. P. Goh, Keith J. Roberts, Ugo Boggi, Vasileios K. Mavroeidis, Steven White, Geert Kazemier, Bergthor Björnsson, Mario Serradilla-Martin, Michael G. House, Adnan Alseidi, Benedetto Ielpo, Michele Mazzola, Nigel Jamieson, Ulrich Wellner, Zahir Soonawalla, Santiago Sanchez Cabus, Raffaele Dalla Valle, Patrick Pessaux, Miljana Vladimirov, Tara S. Kent, Chung N. Tang, William E. Fisher, Jorg Kleeff, Alessandro Mazzotta, Miguel Angel Suarez Munoz, Adam C. Berger, Chad G. Ball, Dimitris Korkolis, Elisa Bannone, Clarissa Ferarri, Marc G. Besselink, Mohammed Abu Hilal (2024) The Five Periampullary Cancers, not Just Different Siblings but Different Families: An International Multicenter Cohort Study Annals of Surgical Oncology (Article in journal) Continue to DOI
Linda Bojmar, Constantinos Zambirinis, Jonathan M. Hernandez, Jayasree Chakraborty, Lee Shaashua, Junbum Kim, Kofi Ennu Johnson, Samer Hanna, Gokce Askan, Jonas Burman, Hiranmayi Ravichandran, Jian Zheng, Joshua S. Jolissaint, Rami Srouji, Yi Song, Ankur Choubey, Han Sang Kim, Michele Cioffi, Elke van Beek, Carlie Sigel, Jose Jessurun, Paulina Velasco Riestra, Hakon Blomstrand, Carolin Jönsson, Anette Jönsson, Pernille Lauritzen, Weston Buehring, Yonathan Ararso, Dylanne Hernandez, Jessica P. Vinagolu-Baur, Madison Friedman, Caroline Glidden, Laetitia Firmenich, Grace Lieberman, Dianna L. Mejia, Naaz Nasar, Anders P. Mutvei, Doru M. Paul, Yaron Bram, Bruno Costa-Silva, Olca Basturk, Nancy Boudreau, Haiying Zhang, Irina R. Matei, Ayuko Hoshino, David Kelsen, Irit Sagi, Avigdor Scherz, Ruth Scherz-Shouval, Yosef Yarden, Moshe Oren, Mikala Egeblad, Jason S. Lewis, Kayvan Keshari, Paul M. Grandgenett, Michael A. Hollingsworth, Vinagolu K. Rajasekhar, John H. Healey, Bergthor Björnsson, Diane M. Simeone, David A. Tuveson, Christine A. Iacobuzio-Donahue, Jaqueline Bromberg, C. Theresa Vincent, Eileen M. O'Reilly, Ronald P. DeMatteo, Vinod P. Balachandran, Michael I. D'Angelica, T. Peter Kingham, Peter J. Allen, Amber L. Simpson, Olivier Elemento, Per Sandström, Robert E. Schwartz, William R. Jarnagin, David Lyden (2024) Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer Nature Medicine (Article in journal) Continue to DOI

Research

Liver and pancreatic tumors

The research I conduct can be divided into clinical projects and trials where the aim is to improve care for today's patients within a short time and translational projects where the aim is to increase knowledge and understanding of underlying mechanisms.

Clinical projects

In the DRAGON network, we investigate methods to stimulate liver growth with as little intervention as possible. The core of the method being explored is that in addition to embolization of the portal vein, the hepatic vein(s) are also embolized to increase growth of the liver that can be left behind during surgery.

The DIPLOMA studies are about comparing the minimally invasive surgical method for pancreatic tumors with the classic open operations to ensure the introduction and expansion of minimally invasive pancreatic surgery. Within the same area is E-MIPS, the European registry for minimally invasive pancreatic surgery.

The ISGACA collaboration focuses on the management of tumors in the bile duct, its mouth and in the duodenum. A number of retrospective multicenter studies have already been done and the prospective ADAPTA study will investigate the choice of chemotherapy for tumors in the bile duct mouth.

The NorPact collaboration is investigating the value of pretreatment with chemotherapy before surgery for pancreatic cancer. Results of a prospective randomized trial are expected shortly.

In the ScanPan project, which is a Nordic collaboration starting from Linköping, clinical research in liver and pancreas areas meets where the value of treatment in pancreatic cancer that has spread (to the liver) is investigated.

 

Translational projects

Zebrafish embryos are used to investigate tumor characteristics in colon cancer, liver metastases (daughter tumors) and pancreatic cancer. The overall goal of these studies is to be able to provide more targeted chemotherapy based on the individual patient's tumor. The collaboration with basic research is with Lasse Jansen.
The liver's propensity to receive daughter tumors from colon and rectal cancer and pancreatic cancer is investigated in a project run in collaboration with Linda Bojmar.

I am a member of Bojmar Lab

A banner with focus on cancer research.

Bojmar Lab

Cancer is a systemic disease. Our research focuses on understanding crosstalk between different organs in the human body, and how this affects cancer progression. We focus mainly on gastrointestinal cancers and their common hepatic metastasis.

Organisation

Teaser image for the division KOO at BKV.

Division of Surgery, Orthopedics and Oncology (KOO)

We carry out research in the fields of experimental orthopedics, surgery and oncology.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

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