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Jonas Klingström


Our research aims to understand the mechanisms behind how zoonotic viruses cause disease in humans. More specifically, we focus on how hantavirus and coronavirus modulate inflammatory responses and cell-cell-signaling.

Understanding the pathogenesis of zoonotic viruses

Our research aims to understand the mechanisms behind how zoonotic viruses cause disease in humans. More specifically, we focus on how hantavirus and coronavirus modulate inflammatory responses and cell-cell-signaling. Ultimately, our goal is to contribute to the development of specific treatment for patients.

Zoonotic viruses are viruses that can be transmitted between animals and humans. Hantaviruses are zoonotic viruses that are transmitted to humans via rodent excreta. The main focus of our research is to understand how hantaviruses cause disease in humans. Depending on the virus strain, hantaviruses can cause two severe diseases in humans - hemorrhagic fever with renal syndrome (HFRS), in Europe and Asia, and hantavirus pulmonary syndrome (HPS) in the Americas. HFRS and HPS both give rise to acute flu-like illness with fever, headache, and stomachache as common symptoms. HFRS often causes a transient renal dysfunction while HPS primarily affects the lungs and can rapidly progress into life-threatening lung failure. In contrast to HFRS, which is seldom fatal, HPS has a case-fatality rate of up to 40%. The mechanisms behind how hantaviruses cause disease are unknown and no FDA/EMA-approved hantavirus vaccine or treatment exists.

Upon infection, hantavirus spreads systemically via endothelial cells. Hallmarks of HFRS and HPS include strong inflammatory responses and increased vascular permeability. Using blood samples from HFRS/HPS patients and in vitro infection models, we try to identify key mechanisms behind how hantaviruses cause inflammation in humans, and the consequences of this inflammation. Mapping of the human immune response to hantavirus allows us to search for immunological factors that are associated with disease severity and fatality. To explore the mechanisms behind these findings, we re-capitulate these responses using in vitro infection models with primary endothelial cells and immune cells. Moreover, by comparing the effects of different hantaviruses of varying pathogenicities, we can identify disease-driving pathways.


Selected publications

Latest publications in LiU DiVA


Oscar Bladh, Katherina Aguilera, Ulrika Marking, Martha Kihlgren, Nina Greilert Norin, Anna Smed-Sorensen, Margaret Sallberg Chen, Jonas Klingström, Kim Blom, Michael W. Russell, Sebastian Havervall, Charlotte Thalin, Mikael Aberg (2024) Comparison of SARS-CoV-2 spike-specific IgA and IgG in nasal secretions, saliva and serum Frontiers in Immunology, Vol. 15, Article 1346749 Continue to DOI
Wanda Christ, Jonas Klingström, Janne Tynell (2024) SARS-CoV-2 variant-specific differences in inhibiting the effects of the PKR-activated integrated stress response Virus Research, Vol. 339, Article 199271 Continue to DOI


Jens H. Kuhn, Junya Abe, Scott Adkins, Sergey V. Alkhovsky, Tatjana Avšič-Županc, María A. Ayllón, Justin Bahl, Anne Balkema-Buschmann, Matthew J. Ballinger, Virendra Kumar Baranwal, Martin Beer, Nicolas Bejerman, Éric Bergeron, Nadine Biedenkopf, Carol D. Blair, Kim R. Blasdell, Arnaud G. Blouin, Steven B. Bradfute, Thomas Briese, Paul A. Brown, Ursula J. Buchholz, Michael J. Buchmeier, Alexander Bukreyev, Felicity Burt, Carmen Büttner, Charles H. Calisher, Mengji Cao, Inmaculada Casas, Kartik Chandran, Rémi N. Charrel, Krishna Kumar Chaturvedi, Kar Mun Chooi, Anya Crane, Elena Dal Bó, Juan Carlos de la Torre, William M. de Souza, Rik L. de Swart, Humberto Debat, Nolwenn M. Dheilly, Nicholas Di Paola, Francesco Di Serio, Ralf G. Dietzgen, Michele Digiaro, J. Felix Drexler, W. Paul Duprex, Ralf Dürrwald, Andrew J. Easton, Toufic Elbeaino, Koray Ergünay, Guozhong Feng, Jonas Klingström (2023) Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota) Journal of General Virology, Vol. 104 Continue to DOI
Oscar Bladh, Nina Greilert-Norin, Sebastian Havervall, Ulrika Marking, Katherina Aguilera, Jessica J. Alm, Kim Blom, Mikael Aberg, Jonas Klingström, Charlotte Thalin (2023) Mucosal and Serum Antibodies 3 Weeks after Symptomatic BA.2.86 Infection New England Journal of Medicine, Vol. 389, p. 1626-1628 Continue to DOI
Haris Babacic, Wanda Christ, Jose Eduardo Araujo, Georgios Mermelekas, Nidhi Sharma, Janne Tynell, Marina Garcia, Renata Varnaite, Hilmir Asgeirsson, Hedvig Glans, Janne Lehtioe, Sara Gredmark-Russ, Jonas Klingström, Maria Pernemalm (2023) Comprehensive proteomics and meta-analysis of COVID-19 host response Nature Communications, Vol. 14, Article 5921 Continue to DOI