Olof Ivar Stendahl

Tuberculosis and innate immunity – from bench to bedside

Ur aim is to understand the pathogenicity of Mycobacterium tuberculosis (Mtb) focusing on innate immune host defense

Using experimental models and clinical field studies in Ethiopia, we have previously shown that nitrix oxide may play a role in the host defense against mycobacteria.

We are presently focusing on how coinfections with helminths and Mtb affect the immune response, treatment and outcome. Our research is translational combining experimental and clinical studies in Linköping, Ethiopia and Peru.

Publications

Selected publication

Jonna Idh, Blanka Andersson, Maria Lerm, Johanna Raffetseder, Daniel Eklund, Hanna Woksepp, Jim Werngren, Mikael Mansjo, Tommy Sundqvist, Olle Stendahl, Thomas Schön (2017)

Reduced susceptibility of clinical strains of Mycobacterium tuberculosis to reactive nitrogen species promotes survival in activated macrophages

PLOS ONE , Vol.12

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Henrik Andersson, Daniel Eklund, Eyler Ngoh, Alexander Persson, Blanka Andersson, Kristoffer Svensson, Maria Lerm, Robert Blomgran, Olle Stendahl (2014)

Apoptotic neutrophils augment the inflammatory response to Mycobacterium tuberculosis infection in human macrophages

PLOS ONE , Vol.9 , s.e101514-

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More publications in DiVA

2023

Giggil Pushpamithran, Camilla Skoglund, Fanny Olsson, Melissa Méndez, Thomas Schön, Mårten Segelmark, Olle Stendahl, Robert H. Gilman, Robert Blomgran (2023)

No impact of helminth coinfection in patients with smear positive tuberculosis on immunoglobulin levels using a novel method measuring Mycobacterium tuberculosis-specific antibodies Allergy, Asthma & Clinical Immunology, Vol. 19, Article 55 (Article in journal)

https://dx.doi.org/10.1186/s13223-023-00808-0

Organisation

Teaser image for the division II at BKV.

Division of Inflammation and Infection (II)

The Division of Inflammation and Infection (II) includes clinical subject areas such as Immunology, Rheumatology, Pathology and Microbiology.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.