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Urban Karlsson

Principal Research Engineer

Publications

2026

Pei Xin Boon, Amaia Jauregi-Miguel, Sümeyye Süheda Yasarbas, Serena Pozzi, Urban Karlsson, Ammar Husami, Charmaine Ko, Amelle Shillington, Antonios Pantazis (2026) Differential negative dominance by KCNA2 variants associated with global developmental delay suggests KCNA2 haploinsufficiency in humans Journal of Physiology, Vol. 604, p. 3413-3430 (Article in journal) https://dx.doi.org/10.1113/jp290728
Pei Xin Boon, Amaia Jauregi Miguel, Sümeyye Süheda Yasarbas, Serena Pozzi, Urban Karlsson, Ammar Husami, Charmaine Ko, Amelle Shillington, Antonios Pantazis (2026) Differential negative dominance by KCNA2 variants associated with global developmental delay suggests KCNA2 haploinsufficiency in humans Journal of Physiology (Article in journal) https://dx.doi.org/10.1113/JP290728

2022

Serge Moudio, Fredrik Rodin, Nazira Albargothy, Urban Karlsson, Juan Reyes, Martin Hallbeck (2022) Exposure of alpha-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinsons Disease Frontiers in Neurology, Vol. 13, Article 826102 (Article in journal) https://dx.doi.org/10.3389/fneur.2022.826102

2021

Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Argel Estrada Mondragón, Michelle Nilsson, Urban Karlsson, Melanie Schupp, Salome Rognant, Thomas Andrew Jepps, Peter Konradsson, Fredrik Elinder (2021) Synthetic resin acid derivatives selectively open the hK(V)7.2/7.3 channel and prevent epileptic seizures Epilepsia, Vol. 62, p. 1744-1758 (Article in journal) https://dx.doi.org/10.1111/epi.16932

2020

Johan Larsson, Urban Karlsson, Xiongyu Wu, Sara Liin (2020) Combining endocannabinoids with retigabine for enhanced M-channel effect and improved KV7 subtype selectivity The Journal of General Physiology, Vol. 152, Article e202012576 (Article in journal) https://dx.doi.org/10.1085/jgp.202012576

News

Nina Ottosson in the lab.

A drug from resin to combat epileptic seizures

New molecules, developed by researchers at Linköping University, have promising properties as possible drugs against epilepsy. A study published in the journal Epilepsia shows that several of the molecules have antiseizure effects.

Publications

2026

Pei Xin Boon, Amaia Jauregi-Miguel, Sümeyye Süheda Yasarbas, Serena Pozzi, Urban Karlsson, Ammar Husami, Charmaine Ko, Amelle Shillington, Antonios Pantazis (2026) Differential negative dominance by KCNA2 variants associated with global developmental delay suggests KCNA2 haploinsufficiency in humans Journal of Physiology, Vol. 604, p. 3413-3430 (Article in journal) https://dx.doi.org/10.1113/jp290728
Pei Xin Boon, Amaia Jauregi Miguel, Sümeyye Süheda Yasarbas, Serena Pozzi, Urban Karlsson, Ammar Husami, Charmaine Ko, Amelle Shillington, Antonios Pantazis (2026) Differential negative dominance by KCNA2 variants associated with global developmental delay suggests KCNA2 haploinsufficiency in humans Journal of Physiology (Article in journal) https://dx.doi.org/10.1113/JP290728

2022

Serge Moudio, Fredrik Rodin, Nazira Albargothy, Urban Karlsson, Juan Reyes, Martin Hallbeck (2022) Exposure of alpha-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinsons Disease Frontiers in Neurology, Vol. 13, Article 826102 (Article in journal) https://dx.doi.org/10.3389/fneur.2022.826102

2021

Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Argel Estrada Mondragón, Michelle Nilsson, Urban Karlsson, Melanie Schupp, Salome Rognant, Thomas Andrew Jepps, Peter Konradsson, Fredrik Elinder (2021) Synthetic resin acid derivatives selectively open the hK(V)7.2/7.3 channel and prevent epileptic seizures Epilepsia, Vol. 62, p. 1744-1758 (Article in journal) https://dx.doi.org/10.1111/epi.16932

2020

Johan Larsson, Urban Karlsson, Xiongyu Wu, Sara Liin (2020) Combining endocannabinoids with retigabine for enhanced M-channel effect and improved KV7 subtype selectivity The Journal of General Physiology, Vol. 152, Article e202012576 (Article in journal) https://dx.doi.org/10.1085/jgp.202012576

My research

Molecular physiology of voltage-gated ion channels.

Molecular physiology of voltage-gated ion channels

Voltage-gated ion channels are key players in all biological systems where they generate and modulate for instance the nervous impulse and pacemaker activity in the heart and the brain.