Neuroengineering publications

En bild på neuroteknikgruppens avhandlingar

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2019

Teresa Nordin, Peter Zsigmond, Sonia Pujol, Carl-Fredrik Westin, Karin Wårdell, White matter tracing combined with electric field simulation - a patient-specific approach for deep brain stimulation, Neuroimage: Clinical, In press 2019

Pham T, Eklund A, Wårdell K, Salerud G, Classification of Short Time Series in Early Parkinson's Disease with Deep Learning of Fuzzy Recurrence Plots, IEEE/CAA Journal of Automatica Sinica, Accepted 2019

Johansson JD, Alonso F, Wårdell K, Patient-Specific Simulations of Deep Brain Stimulation Electric Field with Aid of In-house Software ELMA, 41st IEEE-EMBC, pp 5212-5216, 2019

Wårdell K, Hemm-Ode S, Zsigmond P, A System for Combined Laser Doppler Flowmetry and Microelectrode Recording during Deep Brain Stimulation Implantation41st IEEE-EMBC, pp 3759-3761, 2019

Latorre MA and Wårdell K, A Comparison between Single and Double Cable Neuron Models Applicable to Deep Brain Stimulation , Biomedical Physics & Engineering Express, 5(2),1-13, 2019.

Michaela Mainz, David Black, Neda Haj-Hosseini, Auditory and Visual User Interface for Optical Guidance During Stereotactic Brain Tumor Biopsies, Accepted, IEEE EMBC conference, 2019

2018

Fabiola Alonso, Models and Simulations of the Electric Field in Deep Brain Stimulation: Comparison of Lead Designs, Operating Modes and Tissue Conductivity, Linköping Studies in Science and Technology, Doctorate Thesis No. 1945, 2018, ISSN 0345-7524.

Shah AA, Alonso F, Vogel D, Wårdell K, Coste J, Lemaire JJ, Pison D, Hemm S. Analysis of adverse effects of stimulation during DBS surgery by patient-specific FEM simulations. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:2222-2225.

Johansson JD, Alonso F, Wårdell K, Modelling Details for Electric Field Simulations of Deep Brain Stimulation. In: Lhotska L, Sukupova L, Lackovic I, Ibbott G (eds). IFMBE Proceedings Springer, pp 645-648, vol 68/1, 2018.

Haj-Hosseini N; Richter J; Kobayashi Frisk L; Milos P; Hallbeck M; Wårdell K, Fluorescence Guidance for Brain Tumour Biopsies,OSA Biophotonics Conference, Florida, USA, 2018.

Wårdell K, Zsigmond P, Richter J, Hemm S Optical Guidance System for Deep Brain Stimulation Surgery – from Experimental Studies to Clinical Use, OSA, Biophotonics Conference, Florida, USA, 2018.

Haj-Hosseini N., Richter J, Milos P., Hallbeck M., Wårdell K 5-ALA fluorescence and laser Doppler flowmetry for guidance in a stereotactic brain tumor biopsy , Biomedical Optics Express, 9(5), 2018

Black D, Hahn H, Kikinis R, Wårdell K, Haj-Hosseini N. Auditory display for fluorescence-guided open brain tumor surgery , International Journal of Computer Assisted Radiology and Surgery, 13(1), 2018

Alonso F., Vogel D., Johansson J., Wårdell K, Hemm-Ode S. Electric Field Comparison between Microelectrode Recording and Deep Brain Stimulation Systems-A Simulation Study , Brain Sci., 8(2), 2018

Zsigmond P., Hemm-Ode S., Wårdell K. Optical Measurements during Deep Brain Stimulation Lead Implantation: Safety Aspects , Stereotact Funct Neurosurg., 95(6):392-399, 2018

Rejmstad P, Haj-Hosseini N, Åneman O, Wårdell K. Optical monitoring of cerebral microcirculation in neurointensive care , Medical & Biological Engineering & Computing, Vol 56 (7), pp 1201–1210, 2018

2017

Johan Richter, Fluorescence Guided Resection of Brain Tumors: Evaluation of a Hand-held Spectroscopic Probe, Linköping University Medical Dissertations, Doctorate Thesis No. 1581, 2017, ISSN 0345-0082.

Malcolm Latorre, The Physical Axon: Modeling, Simulation and Electrode Evaluation, Linköping studies in Science and Technology, Doctorate Thesis No. 1847, 2017, ISBN 0345-7524.

Peter Rejmstad, Optical Monitoring of Cerebral Microcirculation , Linköping studies in Science and Technology, Doctorate Thesis No. 1807, 2017, ISBN 0345-7524.

Akbarian-Tefaghi L, Harith A, Johansson J, Zrinzo L, Zinovia K, Limousin P, Eileen J, Hariz M, Wårdell K, Foltynie T, Refining the Deep Brain Stimulation Target within the Limbic Globus Pallidus Internus for Tourette Syndrome , Stereotactic and Functional Neurosurgery, Vol. 95, nr 4, pp 251-258, 2017

Richter J, Haj-Hosseini N, Hallbeck M, Wårdell K, Combination of Hand-Held Probe and Microscopy for Fluorescence Guided Surgery in the Brain Tumor Marginal Zone , Journal of Photodiagnosis and Photodynamic Therapy, Vol. 18, pp 185-192, 2017

Rejmstad P, Zsigmond P, Wårdell K, Oxygen saturation estimation in brain tissue using diffuse reflectance spectroscopy along stereotactic trajectories, Optics Express. vol 25, no. 7, pp8192:8201, 2017

2016

Hemm-Ode S, Pison D, Alonso F, Shah A, Coste J, Lemaire JJ, Wårdell K, Patient-specific electric field simulations and acceleration measurements for objective analysis of intraoperative stimulation test in the thalamus, Front. Hum. Neurosci. 25 November 2016, doi: 10.3389/fnhum.2016.00577, 2016

Wårdell K, Optical Techniques for Navigation during in Stereotactic Neurosurgery, Sensors and Materials, Vol. 28, No. 10 (2016) 1105–1116, doi: 10.18494/SAM.2016.1272, 2016

Alonso F, Latorre M A, Göransson N, Zsigmond P and Wårdell K, Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study, Brain Sciences, 6(3), 39; doi:10.3390/brainsci6030039, 2016

Rejmstad P, Johansson JD, Haj-Hosseini N, Wårdell K, A method for monitoring of oxygen saturation changes in brain tissue using diffuse reflectance spectroscopy, Journal of Biophotonics, DOI: 10.1002/jbio.201500334, 2016

Wårdell K, Hemm-Ode S, Rejmstad P, Zsigmond P, High-Resolution Laser Doppler Measurements of Microcirculation in the Deep Brain Structures: A Method for Potential Vessel Tracking, Stereotact Funct Neurosurg 2016;94:1-9 (DOI:10.1159/000442894), 2016

2015

Latorre M, Chan A.D.C, Wårdell K, A physical axon potential generator: design, implementation and evaluation, Frontiers in Neuroscience, 20 October 2015, 9:371. doi: 10.3389/fnins.2015.00371, 2015

Malcolm Latorre, Action Potential Generator and Electrode Testing, Linköping studies in Science and Technology, Licentiate Thesis No. 1725, 2015, ISBN 978-91-7685-974-2.

Alonso F, Hemm-Ode S, Wårdell K, Influence on Deep Brain Stimulation from Lead Design, Operating Mode and Tissue Impedance Changes – A Simulation Study, Brain Disorders and Therapy, June 2015, DOI: 10.4172/2168-975X.1000169, 2015, DiVA link

Rejmstad P, Åkesson G, Åneman O, Wårdell K, A laser Doppler system for monitoring cerebral microcirculation: implementation and evaluation during neurosurgery, Medical & Biological Engineering & Computing, 2016, 54:123–131, DOI 10.1007/s11517-015-1332-5

Haj-Hosseini N, Richter JCO, Hallbeck M, Wårdell K, Low dose 5-aminolevulinic acid: Implications in spectroscopic measurements during brain tumor surgery, Photodiagnosis and Photodynamic Therapy, Volume 12, Issue 2, June 2015, Pages 209–214, DOI:10.1016/j.pdpdt.2015.03.004, 2015. DiVA link

2014

Åström M, Diczfalusy E, Martens H, Wårdell K, Relationship between Neural Activation and Electric Field Distribution during Deep Brain Stimulation, IEEE Trans Biomed Eng. 2014 Oct 23. [Epub ahead of print] PMID:25350910, 2014.

Wårdell K, Kefalopoulou Z, Diczfalusy E, Andersson M, Aström M, Limousin P, Zrinzo L, Hariz M, Deep Brain Stimulation of the Pallidum Internum for Gilles de la Tourette Syndrome: A Patient-Specific Model-Based Simulation Study of the Electric Field, Neuromodulation. 2014 Oct 6. DOI: 10.1111/ner.12248., 2014.

Zsigmond P, Nord M, Kullman A, Diczfalusy E, Wårdell K and Dizdar N, Neurotransmitter levels in basal ganglia during levodopa and Deep Brain Stimulation treatment in Parkinson´s Disease, Neurology and Clinical Neuroscience 07/2014; DOI: 10.1111/ncn3.109, 2014.

Haj-Hosseini N., Kistler B., Wårdell K., Development and characterization of brain tumor mimicking fluorescence phantom, SPIE Photonics West, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI, 2014.

Haj-Hosseini N., Behm P., Shabo I., Wårdell K., Fluorescence spectrocopy using indocyanine green for lymph node mapping , SPIE Photonics West, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII, 2014.

2013

Wårdell K, Zrinzo Z, Hariz M, Andersson M, Patient-Specific Brain Modelling for Deep Brain Stimulation Simulation, The 2013 6th International IEEE EMBS Conference on Neural Engineering proceedings page 148-151.

Wårdell K, Haj-Hosseini N and Hemm S, Comparison between Optical and MRI Trajectories in Stereotactic Neurosurgery, IFMBE Proceeding, Vol. 41, p. 49-51, 2013.

Diczfalusy E, Andersson M, Wårdell K, A diffusion tensor based finite element model of microdialysis in the deep brain, Computer Methods in Biomechanics and Biomedical Engineering 2013, DOI:10.1080/10255842.2013.789103.

2012

Wardell K, Zsigmond P, Richter J, Hemm S Relation Between Laser Doppler Signals and Anatomy During Deep Brain Stimulation Electrode Implantation Towards Vim and STN, Neurosurgery. 2012 Nov 27. [Epub ahead of print], PMID:23190636 DiVA link

Rejmstad P; Akesson G; Hillman J; Wardell K, A laser Doppler system for monitoring of intracerebral microcirculationProceedings of IEEE EMBS: 1988 - 1991, 2012. DiVA link

Diczfalusy E; Dizdar N; Zsigmond P; Kullman A; Loyd D; Wardell K Simulations and visualizations for interpretation of brain microdialysis data during deep brain stimulation Proceedings of IEEE EMBS: 6438 - 6441, 2012. DiVA link

Hirbayashi H, Hariz MI, Wårdell K, Blomstedt P Impact of Parameters of Radiofrequency Coagulation on Volume of Stereotactic Lesion in Pallidotomy and Thalamotomy Stereotact and Funct Neurosurg, 90(5):307-315, 2012. DiVA link

Elin Diczfalusy Modeling and Simulation of Microdialysis in the Deep Brain Structures, Linköping studies in Science and Technology, Licentiate Thesis No. 1549, 2012, ISBN 978-91-7519-805-7.

Haj-Hosseini N Fluorescence Spectroscopy for Quantitative Demarcation of Glioblastoma Using 5-Aminolevulinic AcidLinköping Studies in Science and Technology, Dissertation No. 1463, LiU-Tryck, Linköping 2012, ISBN 978-91-7519-845-3.

Johansson JD, Wårdell K Intracerebral quantitative chromophore estimation from reflectance spectra captured during deep brain stimulation implantation J Biophotonics, Aug 2012. DiVA link

Fytagoridis A, Åström M, Wårdell K, Blomstedt P Stimulation-induced side effects in the posterior subthalamic area: Distribution, characteristics and visualization Clinical Neurology and Neurosurgery, In press, 2012. DiVA link

Åström M, Lemaire JJ and Wårdell K Influence of heterogeneous and anisotropic tissue conductivity on electric field distribution in deep brain stimulation Med Biol Eng Comput, 50(1):23-32, 2012. DiVA link

2011

Diczfalusy E, Zsigmond P, Dizdar N, Kullman A, Loyd D, Wårdell K A model for simulation and patient-specific visualisation of the tissue model of influence during microdialysis Med Biol Eng Comput, 49(12):1459-1469, 2011. DiVA link

Wårdell K, Diczfalusy E, Åström M Patient-Specific Modeling and Simulation of Deep Brain Stimulation In: Studies in Mechanobiology, Tissue Engineering and Biomaterials. Springer-Verlag Berlin Heidelberg 2011. DiVA link

Åström M Modelling, Simulaltion, and Visualization of Deep Brain Stimulation Linköping Studies in Science and Technology, Dissertation No. 1384, LiU-Tryck, Linköping 2011, ISBN 978-91-7393-114-4.

Brydegaard M, Haj-Hosseini N, Wårdell K, Andersson-Engels S Photobleaching-Insensitive Fluorescence Diagnostics in Skin and Brain Tissue, IEEE PHOTONICS JOURNAL, 3(3): 407-421, 2011. DiVA link

Haj-Hosseini N, Lowndes S, Salerud G, Wårdell K Blood interference in fiber-optical based fluorescence guided resection of glioma using 5-aminolevulinic acid, Proc. SPIE 7883, 78833R (2011). DiVA link

Richter JCO, Haj-Hosseini N, Andersson-Engel, S, Wårdell K Fluorescence spectroscopy measurements in ultrasonic navigated resection of malignant brain tumors, Lasers Surg Med, 43(1): 8-14, 2011. DiVA link

2010 and before

J. D. Johansson Spectroscopic method for determination of the absorption coefficient in brain tissue, Journal of Biomedical Optics, Biomed Opt. 2010 Sep-Oct;15(5):057005. DiVA link

Hemm S, Wårdell K Stereotactic implantation of deep brain stimulation electrodes: a review of technical systems, methods and emerging tools, Med Biol Eng Comput 48(7):611-24, 2010. DiVA link

Åström M, Tripoliti E, Hariz MI, Zrinzo LU, Martinez-Torre I, Limousin P, Wårdell K Patient-specific model-based investigation of speech intelligibility and movement during deep brain stimulation, Stereotact Funct Neurosurg 2010;88:224-233 DiVA link

Haj-Hosseini N, Richter J, Andersson-Engels S, Wårdell K Optical touch pointer for fluorescence guided brain tumour resection using 5-aminolevulinic, Lasers Surg Med, Jan;42(1):9-14, 2010. DiVA link

Nord M, Zsigmond P, Kullman A, Årstrand K and Dizdar N The effect of peripheral enzyme inhibitors on Levodopa concentrations in blood and CSF. Mov Disord,15;25(3):363-7, 2010. DiVA link

Wårdell K, Johansson J, Richter J, Blomstedt P Optical measurmetns for guidance during deep brain stimulation surgery, Medical Physics and Biomedical Engineering, World Congress, München, IFMBE Proceeding, Vol. 25/IX, 516-517, 2009. DiVA link

Åström M, Tripoliti E, Zrinzo LU, Martinez-Torre I, Limousin P, Hariz MI, Wårdell K Patient-specific models and simulations of deep brain stimulation for postoperative follow-up, Medical Physics and Biomedical Engineering, World Congress, München, IFMBE Proceedings, 25/IX, 331-334, 2009. DiVA link

Johannes D. Johansson, Ingemar Fredriksson, Karin Wårdell and Ola Eriksson Simulation of reflected light intensity changes during navigation and radio-frequency lesioning in the brain Journal of Biomedical Optics 2009,vol. 14, issue 4, pp. 044040 1-7, 2009 DiVA link

Johansson J D, Blomstedt P, Haj-Hosseini N, Bergenheim A T, Eriksson O, and Wårdell K Combined diffuse light reflectance and electric impedance measurements for navigation aid in deep brain surgery Stereotact Funct Neurosurg 87 105-13 , 2009 DiVA link

Johansson J D Impact of Tissue Characteristics on Radio-Frequency Lesioning and Navigation in the Brain: Simulation, experimental and clinical studies Linköping Studies in Science and Technology, Dissertation No. 1230, LiU-Tryck, Linköping 2009, ISBN 978-91-7393-723-8

Haj-Hosseini N, Richter J, Andersson-Engels S, Wårdell K Photobleaching behavior of protoporphyrin IX during 5-aminolevulinic acid marked glioblastoma detection, Proc. of SPIE Vol. 7161, 716131, 2009. DiVA link

Johansson J D, Blomstedt P, Haj-Hosseini N, Bergenheim A T, Eriksson O, and Wårdell K Combined diffuse light reflectance and electric impedance measurements for navigation aid in deep brain surgery Stereotact Funct Neurosurg 87 105-13, 2009 DiVA link

Astrom M, Zrinzo LU, Tisch S, Tripoliti E, Hariz MI, Wardell K Method for patient-specific finite element modeling and simulation of deep brain stimulation. Med Biol Eng Comput, 2008. DiVA link

Haj-Hosseini N, Andersson-Engels S, Wårdell K Evaluation of a fiber-optic based pulsed laser system for fluorescence spectroscopy, NBC-IFMBE Proceedings 20, 363-366, 2008. DiVA link

Johansson J, Zerbinati A, Wårdell K Diffuse Reflectance Spectroscopy During Experimental Radio Frequency Ablation, NBC-IFMBE Proceedings 20, 371-274, 2008. DiVA link

Antonsson J, Eriksson O, Blomstedt P, Bergenheim AT, Hariz MI, Richter J, Zsigmond P, Wårdell K Diffuse reflectance spectroscopy measurements for tissue type discrimination during deep brain stimulation J Neural, 5(2): 185-190 2008. Eng. 5 1-6, 2008. DiVA link

Ilias MA, Richter J, Westermark F, Brantmark M, Andersson-Engels S and Wårdell K Evaluation of a Fiber-Optic Fluorescence Spectroscopy System to Assist Neurosurgical Tumor Resections, Proc. SPIE-OSA 6631, 663110W, 1-7, 2007. DiVA link

Wårdell K, Blomstedt P, Richter J, Antonsson J, Eriksson O, Zsigmond P, Bergenheim AT, Hariz MI Intracerebral microvascular measurements during deep brain stimulation implantation using laser Doppler perfusion monitoring Stereotac Func Neurosurg;85:279-286, 2007. DiVA link

Wårdell K, Fors C, Antonsson J, Eriksson O. Wårdell A laser Doppler system for intracerebral measurements during stereotactic neurosurgery. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:4083-6.

PhD Thesis
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Fabiola Alonso, Models and Simulations of the Electric Field in Deep Brain Stimulation: Comparison of Lead Designs, Operating Modes and Tissue Conductivity, Linköping Studies in Science and Technology Dissertations No. 1945, 2018.

Johan Richter, Fluorescence Guided Resection of Brain Tumors: Evaluation of a Hand-held Spectroscopic Probe, Linköping University Medical Dissertation No. 1581, 2017.

Malcolm Latorre, The Physical Axon: Modeling, Simulation and Electrode Evaluation, Linköping Studies in Science and Technology Dissertations No1847, 2017.

Peter Rejmstad, Optical Monitoring of Cerebral Microcirculation, Linköping Studies in Science and Technology Dissertations No. 1807, 2017.

Elin Diczfalusy, Modeling and Simulation of Microdialysis in the Deep Brain Structures, Lic. Eng. Thesis No. 1549, 2012.

Neda Haj-Hosseini, "Fluorescence Spectroscopy for Quantitative Demarcation of Glioblastoma Using 5-Aminolevulinic AcidLinköping Studies in Science and Technology Dissertations No.1463, 2012.

Mattias Åström, Modelling, Simulation, and Visualization of Deep Brain StimulationLinköping Studies in Science and Technology DissertationsNo. 1384, 2011.

Johannes Johansson, Impact of Tissue Characteristics on Radio-Frequency Lesioning and Navigation in the Brain: Simulation, experimental and clinical studiesLinköping Studies in Science and Technology Dissertations No.1230, 2009.

Magnus Falk, Towards a broader use of phototesting – in research, clinical practice and skin cancer prevention, Linköping University Medical Dissertation No. 1024, 2007.

Carina Fors, Evaluation of a laser Doppler System for Myocardial Perfusion Monitoring, Lic. Eng. Thesis No. 1326, 2007.

Johan Antonsson, Optical methods for intracerebral measurements during stereotactic and functional neurosurgery – experimental studiesLinköping Studies in Science and Technology Dissertations No.1070, 2007.

Daniel Karlsson, Movement artifacts reduction in laser Doppler blood flowmetry – myocardial perfusion applications”, Linköping Studies in Science and Technology Dissertation No. 935, 2005.

Michail Ilias, Single exposure phototesting and assessment of pigmented skin lesions – Quantitative methods in terms of blood perfusion estimates, Linköping Studies in Science and Technology Dissertation No. 935, 2003.

Ola ErikssonCharacterisation and modelling of radiofrequency lesioning in neurosurgery”, Linköping Studies in Science and Technology Dissertation No. 693, 2001.

Karin WårdellLaser Doppler Perfusion Imager – Methodology and Skin Applications, Studies in Science and Technology,Linköping Studies in Science and Technology Dissertation No.329, 1994.

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