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Ahmed Elserafy

Senior Associate Professor

My research focus on developing a regenerative solution as an Advanced Therapy Medicinal Product, for burn victims and chronic wound patients. The ultimate goal is to construct a multilayer construct, based on autologous somatic and/or stem cells.

Research

Ahmed looking through a microscope.

From lab to patient – Ahmed Elserafy's research heals skin with stem cells

Observing how research can significantly impact people, particularly those affected by conditions like burns, inspires Ahmed Elserafy in his work. Discover more about his involvement in the video.

The Research and Development Unit for Skin and Cultured Cells

Vision

Autologous keratinocytes and stem cells can be expanded, differentiated and combined with other types of cells and/or biomaterials to create variable options for skin regeneration.

Mission

Simple and safe skin regenerative solution for burn victims and chronic wound patients.

Research strategy

The unit has two research directions for skin regeneration. The first direction is based on isolating the patient’s keratinocytes and applying them to the wound area, with or without pre-expansion in culture. The current research in this direction involves optimizing the laboratory procedure towards the European Directives controlling the advanced therapeutic medicinal products (ATMP). The second direction is based on stem cell differentiation into epidermal cells. Several ongoing studies are investigating different strategies to enhance the differentiation. For both types of cells, a multilayer skin construct established, with or without biomaterials, will serve as a possible clinical solution for large skin defects. Currently, we are finalizing our application for our first clinical trial, using autologous cultured keratinocytes for severe burn victims.

Our projects are funded by Region Östergötland and ATMP Sweden.

News

Headshot of a man in a clinical reserch lab.

He heals skin and shares his knowledge

Ahmed Elserafy spends his days researching skin and stem cells and how they can be used in the treatment of burns and wounds that do not heal properly. Over the last few years, he has also written a popular science book – in Arabic.
two researchers in operating theatre.

Stem cell research can help people with hard-to-heal wounds

Advances in burns treatment open up new possibilities for healing other complicated wounds. For the first time, stem cells are now being tested as a treatment for hard-to-heal leg ulcers.

Publications

2024

Sinan Dogan, Folke Sjöberg, Ahmed Elserafy, Zacharias Sjoberg, Islam Mohamedy Abdelrahman, Ingrid Steinvall, Matilda Karlsson, Pia Olofsson, Andrew Lindford, Jyrki Vuola, Moustafa Elmasry (2024) Advancements in skin grafting: Development and application of a novel two-blade dermatome for concurrent split-thickness and dermal graft harvesting Burns, Vol. 50, Article 107289 (Article in journal) Continue to DOI
Hady Shahin, Luigi Belcastro, Jyotirmoy Das, Marina Perdiki Grigoriadi, Rolf Saager, Ingrid Steinvall, Folke Sjöberg, Pia Olofsson, Moustafa Elmasry, Ahmed Elserafy (2024) MicroRNA-155 mediates multiple gene regulations pertinent to the role of human adipose-derived mesenchymal stem cells in skin regeneration Frontiers in Bioengineering and Biotechnology, Vol. 12, Article 1328504 (Article in journal) Continue to DOI
Raghad Alghazali, Ahmed Nugud, Ahmed Elserafy (2024) Glycan Modifications as Regulators of Stem Cell Fate Biology, Vol. 13, Article 76 (Article, review/survey) Continue to DOI
Ahmed Taher Elserafy (2024) Stem Cells, From A to B [Arabic]

2023

Hady Shahin, Sallam Abdallah, Jyotirmoy Das, Weihai He, Ibrahim El Serafi, Ingrid Steinvall, Folke Sjöberg, Moustafa Elmasry, Ahmed Elserafy (2023) miRNome and Proteome Profiling of Human Keratinocytes and Adipose Derived Stem Cells Proposed miRNA-Mediated Regulations of Epidermal Growth Factor and Interleukin 1-Alpha International Journal of Molecular Sciences, Vol. 24, Article 4956 (Article in journal) Continue to DOI

More publications

See publications (Google Scholar)

Organisation

Teaser image for the division KOO at BKV.

Division of Surgery, Orthopedics and Oncology (KOO)

We carry out research in the fields of experimental orthopedics, surgery and oncology.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

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