Clinical and experimental rheumatology

The rheumatic diseases, such as rheumatoid arthritis (RA), spondylarthritis and systemic lupus erythematosus (SLE) belong to the endemic diseases, affecting more than 1 percent of the population of Sweden.

The immune system which protects us from bacterial and viral infections may in certain individuals with genetic susceptibility which are exposed to certain environmental factors loose its tolerance and attack endogenous tissues and organs. Knowledge on the etiology of rheumatic disease is increasing, and the number of treatment options for patients who suffer has risen dramatically in recent years.

My group is studying underlying mechanisms for rheumatic diseases, especially SLE, as well as biomarkers and autoantibodies in relation to diagnosis, treatment response and prognosis.



Selected publications

Conformational state of C-reactive protein is critical for reducing immune complex-triggered type I interferon response: Implications for pathogenic mechanisms in autoimmune diseases imprinted by type I interferon gene dysregulation

Svanberg C, Enocsson H, Govender M, Martinsson K, Potempa LA, Rajab IM, Fernandez-Botran R, Wetterö J, Larsson M och Sjöwall C.

Journal of Autoimmunity, 2023-02-01, Volume 135, Article 102998, Copyright © 2023 The Authors

Graphical Abstract.

C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205

Enocsson H, Gullstrand B, Eloranta M-L, Wetterö J, Leonard D, Rönnblom L, Bengtsson A och Sjöwall C.

Front. Immunol., 28 January 2021 |

Figure 2 CRP levels among patients with and without detectable IL-6 levels (Z-axis) along with different CRP genotype (rs1205) and type I IFN gene signature (IGS) status (X-axis). Bars show median values.

Soluble urokinase plasminogen activator receptor (suPAR) levels predict damage accrual in patients with recent-onset systemic lupus erythematosus.

Enocsson H, Wirestam L, Dahle C, Padyukov L, Jönsen A, Urowitz MB, Gladman DD, Romero-Diaz J, Bae SC, Fortin PR, Sanchez-Guerrero J, Clarke AE, Bernatsky S, Gordon C, Hanly JG, Wallace DJ, Isenberg DA, Rahman A, Merrill JT, Ginzler E, Alarcón GS, Chatham WW, Petri M, Khamashta M, Aranow C, Mackay M, Dooley MA, Manzi S, Ramsey-Goldman R, Nived O, Steinsson K, Zoma AA, Ruiz-Irastorza G, Lim SS, Kalunian KC, Inanc M, van Vollenhoven RF, Ramos-Casals M, Kamen DL, Jacobsen S, Peschken CA, Askanase A, Stoll T, Bruce IN, Wetterö J, Sjöwall C.

J Autoimmun. 2020 Jan;106:102340. doi: 10.1016/j.jaut.2019.102340. Epub 2019 Oct 17. (pubmed)

Bilder Christopher Sjöwall forskningsledare.

Latest publications in DiVA



Sule Yavuz, Pascal Pucholt, Johanna K. Sandling, Matteo Bianchi, Dag Leonard, Karin Bolin, Juliana Imgenberg-Kreuz, Maija-Leena Eloranta, Sergey V Kozyrev, Cristina M. Lanata, Andreas Jönsen, Anders A. Bengtsson, Christopher Sjöwall, Elisabet Svenungsson, Iva Gunnarsson, Solbritt Rantapää-Dahlqvist, Joanne Nititham, Lindsey A. Criswell, Kerstin Lindblad-Toh, Lars Rönnblom (2022) Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease Lupus Science and Medicine, Vol. 9, Article e000752 Continue to DOI
Christian Lundtoft, Christopher Sjöwall, Solbritt Rantapaa-Dahlqvist, Anders A. Bengtsson, Andreas Jönsen, Pascal Pucholt, Yee Ling Wu, Emeli Lundström, Maija-Leena Eloranta, Iva Gunnarsson, Eva Baecklund, Roland Jonsson, Daniel Hammenfors, Helena Forsblad-d’Elia, Per Eriksson, Thomas Mandl, Sara Bucher, Katrine B. Norheim, Svein Joar Auglaend Johnsen, Roald Omdal, Marika Kvarnström, Marie Wahren-Herlenius, Lennart Truedsson, Bo Nilsson, Sergey V Kozyrev, Matteo Bianchi, Kerstin Lindblad-Toh, Chack-Yung Yu, Gunnel Nordmark, Johanna K. Sandling, Elisabet Svenungsson, Dag Leonard, Lars Rönnblom (2022) Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome Arthritis & Rheumatology, Vol. 74, p. 1842-1850 Continue to DOI

About me

Program teaching

  • Medical programme
  • Biomedical Laboratory Science Programme
  • Doctoral studies


  • Chairman of Working group for Biosimilars in Rheumatology (Swedish Society for Rheumatology, since 2014)
  • Member of the Working group that compose Guidelines for the medical treatment of SLE with an annual update (Swedish Society for Rheumatology, since 2014)
  • Consultant for the Dental and Pharmaceutical Benefits Agency (TLV) in the review and renegotiation of prices for Biologics in Sweden (since 2015)