Photo of Christopher Sjöwall

Christopher Sjöwall

Senior Associate Professor

My long-term ambition is to contribute to increased understanding of underlying mechanisms for disease-onset, progress and quality of life in systemic inflammatory diseases, especially systemic lupus erythematosus.

Clinical and experimental rheumatology

The rheumatic diseases, such as rheumatoid arthritis (RA), spondylarthritis and systemic lupus erythematosus (SLE) belong to the endemic diseases, affecting more than 1 percent of the population of Sweden.

The immune system which protects us from bacterial and viral infections may in certain individuals with genetic susceptibility which are exposed to certain environmental factors loose its tolerance and attack endogenous tissues and organs. Knowledge on the etiology of rheumatic disease is increasing, and the number of treatment options for patients who suffer has risen dramatically in recent years.

My group is studying underlying mechanisms for rheumatic diseases, especially SLE, as well as biomarkers and autoantibodies in relation to diagnosis, treatment response and prognosis.


News

Publications

Selected publications

Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP

Karlsson J, Wetterö J, Potempa LA, Fernandez-Botran R, O'Neill Y, Wirestam L, Mobarrez F and Sjöwall C.

Journal of Autoimmunity, 2023-09-01, Volume 139, Article 103073, https://doi.org/10.1016/j.jaut.2023.103073

Graphical Abstract from the publication: Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP

Conformational state of C-reactive protein is critical for reducing immune complex-triggered type I interferon response: Implications for pathogenic mechanisms in autoimmune diseases imprinted by type I interferon gene dysregulation

Svanberg C, Enocsson H, Govender M, Martinsson K, Potempa LA, Rajab IM, Fernandez-Botran R, Wetterö J, Larsson M och Sjöwall C.

Journal of Autoimmunity, 2023-02-01, Volume 135, Article 102998, Copyright © 2023 The Authors

Graphical Abstract.

 

C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205

Enocsson H, Gullstrand B, Eloranta M-L, Wetterö J, Leonard D, Rönnblom L, Bengtsson A och Sjöwall C.

Front. Immunol., 28 January 2021 | https://doi.org/10.3389/fimmu.2020.622326

Figure 2 CRP levels among patients with and without detectable IL-6 levels (Z-axis) along with different CRP genotype (rs1205) and type I IFN gene signature (IGS) status (X-axis). Bars show median values.

Latest publications in DiVA

2023

Per Lewander, Lina Wirestam, Charlotte Dahle, Jonas Wetterö, Christopher Sjöwall (2023) Serum levels of soluble urokinase plasminogen activator receptor in juvenile idiopathic arthritis: a single-center Swedish case-control study Pediatric Rheumatology, Vol. 21, Article 49 Continue to DOI
Lina Wirestam, Pernilla Benjaminsson Nyberg, Todor Dzhendov, Thomas Gasslander, Per Sandström, Christopher Sjöwall, Bergthor Björnsson (2023) Plasma Osteopontin Reflects Tissue Damage in Acute Pancreatitis Biomedicines, Vol. 11, Article 1627 Continue to DOI
Sandra Lilja, Xinxiu Li, Martin Smelik, Eun Jung Lee, Joseph Loscalzo, Pratheek Bellur Marthanda, Lang Hu, Mattias Magnusson, Oleg Sysoev, Huan Zhang, Yelin Zhao, Christopher Sjöwall, Danuta Gawel, Hui Wang, Mikael Benson (2023) Multi-organ single-cell analysis reveals an on/off switch system with potential for personalized treatment of immunological diseases Cell Reports Medicine, Vol. 4, Article 100956 Continue to DOI
Lina Wirestam, Frida Jönsson, Helena Enocsson, Christina Svensson, Maria Weiner, Jonas Wetterö, Helene Zachrisson, Per Eriksson, Christopher Sjöwall (2023) Limited Association between Antibodies to Oxidized Low-Density Lipoprotein and Vascular Affection in Patients with Established Systemic Lupus Erythematosus International Journal of Molecular Sciences, Vol. 24, Article 8987 Continue to DOI
Ioannis Parodis, Julius Lindblom, Nursen Cetrez, Leonardo Palazzo, Henri Ala, Frederic A. Houssiau, Christopher Sjöwall, Brad H. Rovin (2023) Effect of Belimumab on Preventing de novo Renal Lupus Flares KIDNEY INTERNATIONAL REPORTS, Vol. 8, p. 1822-1830 Continue to DOI

Publications in PubMed and ORCiD

About me

CV

Christopher Sjöwall, associate Professor.Christopher Sjöwall, Senior Associate Professor. Photo credit Ulrik Svedin

Program teaching

  • Medical programme
  • Biomedical Laboratory Science Programme
  • Doctoral studies

Network

  • Member of the Swedish SLE network (since 2010)
  • Chairman of Working group that compose Guidelines for the medical treatment of SLE with an annual update on behalf of the Swedish Society for Rheumatology (since 2018)
  • Member of Employment board, Medical Faculty LiU (since 2021)

Organisation