Mechanisms behind aversion and depressive symtoms in inflammatory and psychiatric diseases

We investigate the mechanisms and circuits underpinning the aversive affective states and the depressive symptoms accompanying inflammatory diseases and major depression

Using cutting edge methodology in mouse genetics, our aim is to elucidate the core circuits of aversion as well as the more specific avenues by which different aversive stimuli such as inflammation and social stress activate these circuits and induce aversion and depressive symptoms.

We have made important contributions to the understanding of how systemic inflammation and inflammatory pain induce a negative affective state (e.g. Fritz et al. 2016, J Clin Invest and Singh et al. 2017, J Clin Invest). Continuing along these lines of research, we now focus on the role of microglia, serotonergic neurons and the melanocortin systems as critical neural substrates for aversive and depressive signaling.

We hope that our research will both generate findings interesting from a scientific perspective and be useful for developing strategies towards the reduction of suffering in sick individuals.

For further details - see down below at "Research"

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Michael Fritz, Anna Klawonn, Anna Nilsson, Anand Kumar Singh, Joanna Zajdel, Daniel Wilhelms, Michael Lazarus, Andreas Löfberg, Maarit Jaarola, Unn Örtegren Kugelberg, Timothy R. Billiar, David J. Hackam, Chhinder P. Sodhi, Matthew D. Breyer, Johan Jakobsson, Markus Schwaninger, Gunther Schuetz, Jan Rodriguez Parkitna, Clifford B. Saper, Anders Blomqvist, David Engblom (2016)

Journal of Clinical Investigation , Vol.126 , s.695-705 Continue to DOI

Anand Kumar Singh, Joanna Zajdel, Elahe Mirrasekhian, Nader Almoosawi, Isabell Frisch, Anna Klawonn, Maarit Jaarola, Michael Fritz, David Engblom (2017)

Journal of Clinical Investigation , Vol.127 , s.1370-1374 Continue to DOI

Anna Klawonn, Michael Fritz, Anna Nilsson, Jordi Bonaventura, Kiseko Shionoya, Elahe Mirrasekhian, Urban Karlsson, Maarit Jaarola, Björn Granseth, Anders Blomqvist, Michael Michaelides, David Engblom (2018)

Journal of Clinical Investigation , Vol.128 , s.3160-3170 Continue to DOI

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