Johan Nordgren

Principal Research Engineer, Docent

Docent in Medical Microbiology.

Virus-host interactions in infection and disease

My research in centered on disentangling host and virus interactions and how these affect infection and disease.

I mainly study gastrointestinal viruses but also emerging and airborne viruses, often in a global health perspective. Through our studies we want to understand how both virus and host factors mediate susceptibility and severity to an infection. We are furthermore working with different infection models for functional studies to unravel virus-host interactions and pathogenic mechanisms on a molecular level.

Publications

Latest publications in LiU DiVA

2023

2022

Research

Fig 2 Immunohistochemistry of rotavirus infected duodenum of mice. Red shows rotavirus infected cells and green activated enteric glia cells.

Gastroviruses

Rotavirus and norovirus (the winter vomiting disease, “vinterkräksjuka”) are major causes of acute diarrhea worldwide. The underlying disease mechanisms are still unresolved.

News

Female researcher studies a cell plate in a laboratory.

Long-term effects on the immune system following COVID-19

The more severe the COVID-19 infection, the slower the recovery of immune cells which are necessary for the activation of the immune system. Six months after severe COVID-19, a negative impact on several types of immune cells can still be seen.

Defective gene renders diarrhoea vaccine ineffective

Every year rotavirus causes half a million diarrhoea-related deaths amongst children in developing countries. Existing vaccines provide poor protection. The reason could be a widespread genetic resistance amongst children, according to virologists at Linköping University.

Organisation

Division of Molecular Medicine and Virology (MMV)

At the division, the research involves studies on the molecular biology level as well as studies of biological effects on cells, on tissue, and organisms. We are also involved in medical and biomedical education programs.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.