Photo of Karin Roberg

Karin Roberg

Adjunct Professor

My goal is to be able to individualize the treatment for each patient and thus improve the survival and quality of life for patients with head and neck cancer

Identification of Biomarkers Influencing Treatment Response and Clinical Prognosis in Head and Neck Cancer

Cancer of the head and neck is the sixth most common form of cancer worldwide with about 1300 new cases per year in Sweden

The majority of all head and neck cancers are squamous cell carcinomas (HNSCC) having their origin in the mucosa of the oral cavity, pharynx, larynx, and nasal cavity.

Despite advances in surgical and oncological treatments that enhance quality of life with a palliative value, the overall survival rate has significantly not increased. A combination of radiotherapy and surgery or definitive chemoradiation is currently the primary mode of treatment for locally advanced HNSCC.

HNSCC often show resistance to treatments and the 5-year survival rate is merely 60%. Thus, there is a paramount need for assessment of predictive biomarkers and new targets for treatment.

Due to the limited predictive value of the currently available biomarkers currently available for guiding treatment recommendations, both under- and over treatment occur, with significant suffering and socio-economic waste as a result.

In this project, patient tumor biopsies, HNSCC cell lines that we have established from tumor biopsies and mice xenografts obtained from these cell lines are used for evaluation of therapies and characterization of tumor cell properties.

The main aim of these studies is to identify biomarkers that influence the response of tumors to anti-cancer therapy. Such factors may be useful predictors of treatment response and valuable tools in the development of personalized medicine. Ideally, these factors are also targetable, providing possibilities for the development of novel therapies.


Publications in DiVA


Aida Ajan, Karin Roberg, Ingemar Fredriksson, Jahan Abtahi (2024) Reproducibility of Laser Doppler Flowmetry in gingival microcirculation. A study on six different protocols Microvascular Research, Vol. 153, Article 104666 Continue to DOI
Natasa Matic, Lina Pettersson, Felicia Sellebjerg, Lina Lindberg, Karin Roberg, Emilia Wiechec (2024) Prognostic value of hypoxia-responsive gene expression profile in patients diagnosed with head and neck squamous cell carcinoma Translational Oncology, Vol. 39, Article 101841 Continue to DOI


Geyunjian H. Zhu, Mohammad Azharuddin, Bapan Pramanik, Karin Roberg, Sujoy Kumar Biswas, Padraig D´arcy, Meng Lu, Apanpreet Kaur, Alexander Chen, Ashis Kumar Dhara, Alexandru Chivu, Yunhui Zhuang, Andrew Baker, Xiewen Liu, David Fairen-Jimenez, Bismoy Mazumder, Rongjun Chen, Clemens F. Kaminski, Gabriele S. Kaminski Schierle, Jorma Hinkula, Nigel K. H. Slater, Hirak K. Patra (2023) Feasibility of Coacervate-Like Nanostructure for Instant Drug Nanoformulation ACS Applied Materials and Interfaces, Vol. 15, p. 17485-17494 Continue to DOI