Nina Ottosson

Publications

2021

Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Argel Estrada Mondragón, Michelle Nilsson, Urban Karlsson, Melanie Schupp, Salome Rognant, Thomas Andrew Jepps, Peter Konradsson, Fredrik Elinder (2021) Synthetic resin acid derivatives selectively open the hK(V)7.2/7.3 channel and prevent epileptic seizures Epilepsia, Vol. 62, p. 1744-1758 Continue to DOI

Malin Silverå Ejneby, Arina Gromova, Nina Ottosson, Stina Borg, Argel Estrada Mondragón, Samira Yazdi, Panagiotis Apostolakis, Fredrik Elinder, Lucie Delemotte (2021) Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Shaker potassium channel The Journal of General Physiology, Vol. 153, Article e202012676 Continue to DOI

2018

Malin Silverå Ejneby, Xiongyu Wu, Nina Ottosson, E Peter Münger, Ingemar Lundström, Peter Konradsson, Fredrik Elinder (2018) Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid The Journal of General Physiology, Vol. 150, p. 731-750 Continue to DOI

Xiongyu Wu, Malin Silverå Ejneby, Nina Ottosson, Fredrik Elinder, Peter Konradsson (2018) A Suzuki-Miyaura Coupling of ortho-Hydroxyaryl Bromide with Isopropenylboronic Pinacol Ester: Synthesis of the Potassium-Channel Opener (+)-Callitrisic Acid European Journal of Organic Chemistry, Vol. 14, p. 1730-1734 Continue to DOI

2017

Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Samira Yazdi, Peter Konradsson, Erik Lindahl, Fredrik Elinder (2017) A drug pocket at the lipid bilayer-potassium channel interface Science Advances, Vol. 3, Article e1701099 Continue to DOI

News

New machine speeds up trials on cells

LiU researchers have used high-throughput electrophysiology experiments with a borrowed machine to see how ion channels in cells are influenced by drugs. A new collaboration with the biotech industry.

A drug from resin to combat epileptic seizures

New molecules, developed by researchers at Linköping University, have promising properties as possible drugs against epilepsy. A study published in the journal Epilepsia shows that several of the molecules have antiseizure effects.

Drug development – not only in industry

Neuroscientists obtain support from SciLifeLab when working to develop new drugs against epilepsy. The project is the first from Linköping University that has been accepted as a full program for the Drug Discovery and Development Platform (DDD).

From the lab to the clinic

Countless companies have been founded on a promising research result or a truly great idea. But what is needed in order to translate this into a product or service? Meet two researchers in neurobiology who have taken on the role of entrepreneur.

New method to dampen nerve signals

Researchers at LiU have discovered a previously unknown molecular binding site that can influence electrical impulses in nerves. The discovery opens the possibility of designing new types of drugs against conditions such as epilepsy.

Resin may provide medicine against epilepsy

Sticky resin from conifers contains substances that could relieve or cure epilepsy. Researchers at Linköping University have synthesized and tested 71 substances known as resin acids, of which twelve are prime candidates for new medicines.

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Publications

2021

Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Argel Estrada Mondragón, Michelle Nilsson, Urban Karlsson, Melanie Schupp, Salome Rognant, Thomas Andrew Jepps, Peter Konradsson, Fredrik Elinder (2021) Synthetic resin acid derivatives selectively open the hK(V)7.2/7.3 channel and prevent epileptic seizures Epilepsia, Vol. 62, p. 1744-1758 Continue to DOI

Malin Silverå Ejneby, Arina Gromova, Nina Ottosson, Stina Borg, Argel Estrada Mondragón, Samira Yazdi, Panagiotis Apostolakis, Fredrik Elinder, Lucie Delemotte (2021) Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Shaker potassium channel The Journal of General Physiology, Vol. 153, Article e202012676 Continue to DOI

2018

Malin Silverå Ejneby, Xiongyu Wu, Nina Ottosson, E Peter Münger, Ingemar Lundström, Peter Konradsson, Fredrik Elinder (2018) Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid The Journal of General Physiology, Vol. 150, p. 731-750 Continue to DOI

Xiongyu Wu, Malin Silverå Ejneby, Nina Ottosson, Fredrik Elinder, Peter Konradsson (2018) A Suzuki-Miyaura Coupling of ortho-Hydroxyaryl Bromide with Isopropenylboronic Pinacol Ester: Synthesis of the Potassium-Channel Opener (+)-Callitrisic Acid European Journal of Organic Chemistry, Vol. 14, p. 1730-1734 Continue to DOI

2017

Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Samira Yazdi, Peter Konradsson, Erik Lindahl, Fredrik Elinder (2017) A drug pocket at the lipid bilayer-potassium channel interface Science Advances, Vol. 3, Article e1701099 Continue to DOI

Tags

• Molecular physiology of voltage-gated ion channels
• Cell and Molecular Biology
• The Brain and the Nervous System
• Employee
• The unit for cell and neurobiology (CNBE)
• The Division of Cell and Neurobiology (CNB)
• Department of Biomedical and Clinical Sciences (BKV)
• Linköping University (LIU)
• Nina Ottosson (ninot92)
• Senior Research Coordinator

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