Nina Ottosson

Publications

2025

Irene Hiniesto Iñigo, Akshay Sridhar, Julien Louradour, Alicia de La Cruz Fernandez, Siri Amalia Lundholm, Amaia Jauregi Miguel, Federica Giannetti, Luca Sala, Katja E. Odening, Peter Larsson, Nina Ottosson, Sara Liin (2025) Rescue of loss-of-function long QT syndrome-associated mutations in K_V7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S) British Journal of Pharmacology (Article in journal) Continue to DOI

2024

Andrea Benediktsdottir, Sanjeewani Sooriyaarachchi, Sha Cao, Nina Ottosson, Stefan Lindstrom, Bo Lundgren, Katharina Kloditz, Daina Lola, Olga Bobileva, Einars Loza, Diarmaid Hughes, T. Alwyn Jones, Sherry L. Mowbray, Edouard Zamaratski, Anja Sandstrom, Anders Karlen (2024) Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors European Journal of Medicinal Chemistry, Vol. 278, Article 116790 (Article in journal) Continue to DOI

2021

Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Argel Estrada Mondragón, Michelle Nilsson, Urban Karlsson, Melanie Schupp, Salome Rognant, Thomas Andrew Jepps, Peter Konradsson, Fredrik Elinder (2021) Synthetic resin acid derivatives selectively open the hK(V)7.2/7.3 channel and prevent epileptic seizures Epilepsia, Vol. 62, p. 1744-1758 (Article in journal) Continue to DOI

Malin Silverå Ejneby, Arina Gromova, Nina Ottosson, Stina Borg, Argel Estrada Mondragón, Samira Yazdi, Panagiotis Apostolakis, Fredrik Elinder, Lucie Delemotte (2021) Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Shaker potassium channel The Journal of General Physiology, Vol. 153, Article e202012676 (Article in journal) Continue to DOI

2018

Malin Silverå Ejneby, Xiongyu Wu, Nina Ottosson, E Peter Münger, Ingemar Lundström, Peter Konradsson, Fredrik Elinder (2018) Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid The Journal of General Physiology, Vol. 150, p. 731-750 (Article in journal) Continue to DOI

News

New machine speeds up trials on cells

LiU researchers have used high-throughput electrophysiology experiments with a borrowed machine to see how ion channels in cells are influenced by drugs. A new collaboration with the biotech industry.

A drug from resin to combat epileptic seizures

New molecules, developed by researchers at Linköping University, have promising properties as possible drugs against epilepsy. A study published in the journal Epilepsia shows that several of the molecules have antiseizure effects.

Drug development – not only in industry

Neuroscientists obtain support from SciLifeLab when working to develop new drugs against epilepsy. The project is the first from Linköping University that has been accepted as a full program for the Drug Discovery and Development Platform (DDD).

New method to dampen nerve signals

Researchers at LiU have discovered a previously unknown molecular binding site that can influence electrical impulses in nerves. The discovery opens the possibility of designing new types of drugs against conditions such as epilepsy.

Resin may provide medicine against epilepsy

Sticky resin from conifers contains substances that could relieve or cure epilepsy. Researchers at Linköping University have synthesized and tested 71 substances known as resin acids, of which twelve are prime candidates for new medicines.

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Publications

2025

Irene Hiniesto Iñigo, Akshay Sridhar, Julien Louradour, Alicia de La Cruz Fernandez, Siri Amalia Lundholm, Amaia Jauregi Miguel, Federica Giannetti, Luca Sala, Katja E. Odening, Peter Larsson, Nina Ottosson, Sara Liin (2025) Rescue of loss-of-function long QT syndrome-associated mutations in K_V7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S) British Journal of Pharmacology (Article in journal) Continue to DOI

2024

Andrea Benediktsdottir, Sanjeewani Sooriyaarachchi, Sha Cao, Nina Ottosson, Stefan Lindstrom, Bo Lundgren, Katharina Kloditz, Daina Lola, Olga Bobileva, Einars Loza, Diarmaid Hughes, T. Alwyn Jones, Sherry L. Mowbray, Edouard Zamaratski, Anja Sandstrom, Anders Karlen (2024) Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors European Journal of Medicinal Chemistry, Vol. 278, Article 116790 (Article in journal) Continue to DOI

2021

Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Argel Estrada Mondragón, Michelle Nilsson, Urban Karlsson, Melanie Schupp, Salome Rognant, Thomas Andrew Jepps, Peter Konradsson, Fredrik Elinder (2021) Synthetic resin acid derivatives selectively open the hK(V)7.2/7.3 channel and prevent epileptic seizures Epilepsia, Vol. 62, p. 1744-1758 (Article in journal) Continue to DOI

Malin Silverå Ejneby, Arina Gromova, Nina Ottosson, Stina Borg, Argel Estrada Mondragón, Samira Yazdi, Panagiotis Apostolakis, Fredrik Elinder, Lucie Delemotte (2021) Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Shaker potassium channel The Journal of General Physiology, Vol. 153, Article e202012676 (Article in journal) Continue to DOI

2018

Malin Silverå Ejneby, Xiongyu Wu, Nina Ottosson, E Peter Münger, Ingemar Lundström, Peter Konradsson, Fredrik Elinder (2018) Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid The Journal of General Physiology, Vol. 150, p. 731-750 (Article in journal) Continue to DOI

My research

Molecular physiology of voltage-gated ion channels

Voltage-gated ion channels are key players in all biological systems where they generate and modulate for instance the nervous impulse and pacemaker activity in the heart and the brain.

Network

SciLifeLab Linköping

SciLifeLab Linköping is both a local and a national research infrastructure, with unique technologies and expert competence accessible for academic and industrial researcher in the field of life sciences, health and data-driven life science.

Tags

• Molecular physiology of voltage-gated ion channels
• Cell and Molecular Biology
• The Brain and the Nervous System
• SciLifeLab
• Employee
• The unit for cell and neurobiology (CNBE)
• The Division of Cell and Neurobiology (CNB)
• Department of Biomedical and Clinical Sciences (BKV)
• Linköping University (LIU)
• Nina Ottosson (ninot92)
• Senior Research Coordinator

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