Peter Gennemark

Adjunct Associate Pr, Docent

My research aims to improve understanding of diabetes and cardiovascular disease and their treatment, by mathematical modelling.

Systems pharmacology – a pharma industry collaboration

Peter Gennemark (Principal scientist at AstraZeneca, Gothenburg, Sweden) is adjunct senior lecturer at IMT. Peter has an established collaboration in systems pharmacology with Gunnar Cedersund (IMT). His research is directed towards systems pharmacology in the diabetes and cardiovascular disease areas, with the aim of increasing knowledge of biology, disease progression and drug intervention in these areas.

Publications

2026

Oscar Silfvergren, Sophie Rigal, Katharina Schimek, Christian Simonsson, Kajsa P. Kanebratt, Felix Forschler, Burcak Yesildag, Uwe Marx, Liisa Vilen, Peter Gennemark, Gunnar Cedersund (2026)

M4 drug discovery: Human drug predictions from integrated preclinical insights exemplified with a GLP-1R agonist European Journal of Pharmaceutical Sciences, Vol. 227, Article 107648 (Article in journal)

https://dx.doi.org/10.1016/j.ejps.2026.107648

Par Nordell, Rasmus Jansson-Lofmark, Peter Gennemark (2026)

Systemic Pharmacokinetic Principles of Therapeutic Peptides Clinical Pharmacokinetics, Vol. 65, p. 571-582 (Article in journal)

https://dx.doi.org/10.1007/s40262-025-01615-z

2025

Quentin Vicentini, Dennis Hekman, Deepak Bhatt, Rouven Stulz, Mahya Dezfouli, Peter Gennemark, Nicola Guzzi, Naoko Toki, Bojana Lazovic, Carolina Tangemo, Shalini Andersson, Samir EL Andaloussi, Anders Dahlen (2025)

Multimeric Conjugates Using Engineered Peptide Scaffolds for Efficient siRNA Delivery Bioconjugate chemistry, Vol. 36, p. 1299-1310 (Article in journal)

https://dx.doi.org/10.1021/acs.bioconjchem.5c00156

2024

Erica Bäckström, Alessandro Bonetti, Per Johnsson, Stefan Öhlin, Anders Dahlén, Patrik Andersson, Shalini Andersson, Peter Gennemark (2024)

Tissue pharmacokinetics of antisense oligonucleotides Molecular Therapy - Nucleic Acids, Vol. 35, p. 102133-102133, Article 102133 (Article in journal)

https://dx.doi.org/10.1016/j.omtn.2024.102133

Hamidreza Arjmandi, Kajsa P. Kanebratt, Liisa Vilen, Peter Gennemark, Adam Noel (2024)

3D cell aggregates amplify diffusion signals PLOS ONE, Vol. 19, Article e0310109 (Article in journal)

https://dx.doi.org/10.1371/journal.pone.0310109

Research

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Systems Biology

By combining mathematical models, prior knowledge, and experimental data, we unravel biological mechanisms and contribute to the development of new drugs and clinical tools.

Research projects

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Knowledge Driven Drug Development

In this project, financed by VR medicine’s investment in pharmacy, the researchers are working with AstraZeneca to develop a new type of knowledge driven drug development.

Organisation

Department of Biomedical Engineering (IMT)

A national centre for research, PhD studies and graduate studies within biomedical engineering, since 1972.

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Division of Biomedical Engineering (MT)

A division for research, education and innovation within the field of biomedical engineering.