How calcium-based sound transduction mechanisms contribute to hearing loss 

I obtained my MSc (2004) and PhD (2008) degrees in biochemistry from the Université Libre de Bruxelles, Belgium. As a PhD student, I was investigated how protein-lipid interactions regulate antibiotic resistance in bacteria. 

During mypostdoctoral studies at Karolinska Institute (Sweden), I was investigated the mechanical behavior of the sound transduction apparatus in conditions that characterise noise-induced hearing loss. 

My current research at Linköping University (Sweden) is focused on molecular processes that take place during the development of noise-induced hearing loss and how these processes can be blocked to prevent hearing loss.

Molecular basis for noise-induced hearing loss

Noise trauma is a leading cause of hearing-loss, but neither curative nor preventive therapy exists because the molecular mechanisms behind this morbidity remain elusive. 

The aim of my research is to express calcium sensors such as GCaMP6 in the hearing organ to investigate how calcium-based sound transduction mechanisms contribute to the development of noise-induced hearing loss and how these mechanisms can be blocked molecularly to prevent hearing loss.

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CV

  • 2004 - MSc in biochemistry, Université Libre de Bruxelles, Belgium
  • 2008 - PhD in biochemistry, Université Libre de Bruxelles, Belgium
  • 2008-2012 - Wenner-Gren Foundations and Karolinska  Institute’s postdoctoral fellowships, Karolinska Institute, Sweden
  • 2012-2013 -  Researcher, Karolinska Institute, Sweden
  • Since 2013 -  Researcher, Linköping University

Teaching programme

BL tutor: 
Introduktionskurs i Medicinsk biologi

Course Coordinator: 
Neurobiology course in Master’s program in experimental and medical biosciences.


Membership, Awards and Prices

Membership in the Association for Research in Otolaryngology (ARO), USA

Tysta skolan Foundations grant

Publications
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Dan Bagger-Sjoback, Karin Stromback, Malou Hultcrantz, Georgios Papatziamos, Henrik Smeds, Niklas Danckwardt-Lilliestrom, Bo Tideholm, Ann Johansson, Sten Hellstrom, Pierre Hakizimana, Anders Fridberger (2015)

Scientific Reports , Vol.5 Continue to DOI

Pierre Hakizimana, William E Brownell, Stefan Jacob, Anders Fridberger (2012)

Nature Communications , Vol.3 Continue to DOI

Pierre Hakizimana, William E Brownell, Stefan Jacob, Anders Fridberger (2012)

Nature Communications , Vol.3 Continue to DOI

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