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Pierfrancesco Pagella

Associate Professor

Organ (re)generation and genome engineering

My research interests involve the study of the mechanisms underlying organ and cell diversity, and using this knowledge to generate bio-engineered 3D human organs, complete with innervation, vascularization, and immune compartments. To this end, I combine stem cell biology, tissue engineering, organ-on-chip, genomics and proteomics approaches. Strong attention is dedicated to the oro/craniofacial complex, using models such as teeth and cancers of the oral cavity.
 

two men in labratory,

Claudio Cantù and Pierfrancesco Pagella. Photo credit John Karlsson

News

Two men in a laboratory.

Discovery reveals how cells respond to each other

The same message can be interpreted differently by different individuals – also among cells. This is shown in a study by researchers at Linköping University who studied cell communication.

Selected publications

Cover of publication 'Exhaustive identification of genome-wide binding events of transcriptional regulators'
Anna Nordin, Pierfrancesco Pagella, Gianluca Zambanini, Claudio Cantù (2024)
Exhaustive identification of genome-wide binding events of transcriptional regulators

Nucleic Acids Research Continue to DOI

Cover of publication 'Cover image for Cell Systems.'
Pierfrancesco Pagella, Simon Söderholm, Anna Nordin, Gianluca Zambanini, Valeria Ghezzi, Amaia Jauregi Miguel, Claudio Cantù (2023)
The time-resolved genomic impact of Wnt/(3-catenin signaling

CELL SYSTEMS , Vol.14 , s.563-581.e7 Continue to DOI

Cover of publication ''
Pierfrancesco Pagella, Shayee Miran, Estrela Neto, Ivan Martin, Meriem Lamghari, Thimios A. Mitsiadis (2020)
Human dental pulp stem cells exhibit enhanced properties in comparison to human bone marrow stem cells on neurites outgrowth

The FASEB Journal , Vol.34 , s.5499-5511 Continue to DOI

Cover of publication 'A single-cell atlas of human teeth'
Pierfrancesco Pagella, Laura de Vargas Roditi, Bernd Stadlinger, Andreas E. Moor, Thimios A. Mitsiadis (2021)
A single-cell atlas of human teeth

iScience , Vol.24 , s.102405-102405 Continue to DOI

Cover of publication 'Adam10-dependent Notch signaling establishes dental epithelial cell boundaries required for enamel formation'
Thimios A. Mitsiadis, Lucia Jimenez-Rojo, Anamaria Balic, Silvio Weber, Paul Saftig, Pierfrancesco Pagella (2022)
Adam10-dependent Notch signaling establishes dental epithelial cell boundaries required for enamel formation

iScience , Vol.25 , s.105154-105154 Continue to DOI

Cover of publication ''
Claudio Cantù, Pierfrancesco Pagella, Tania D Shajiei, Dario Zimmerli, Tomas Valenta, George Hausmann, Konrad Basler, Thimios A Mitsiadis (2017)
A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.

Science Signaling , Vol.10 Continue to DOI

Publications

2024

Anna Nordin, Pierfrancesco Pagella, Gianluca Zambanini, Claudio Cantù (2024) Exhaustive identification of genome-wide binding events of transcriptional regulators Nucleic Acids Research Continue to DOI
Giulia Pizzolato, Lavanya Moparthi, Pierfrancesco Pagella, Claudio Cantù, Padraig D´arcy, Stefan Koch (2024) The tumour suppressor p53 is a negative regulator of the carcinoma-associated transcription factor FOXQ1 Journal of Biological Chemistry, Vol. 300, Article 107126 Continue to DOI

2023

Anamaria Balic, Dilara Perver, Pierfrancesco Pagella, Hubert Rehrauer, Bernd Stadlinger, Andreas E. Moor, Viola Vogel, Thimios A. Mitsiadis (2023) Extracellular matrix remodelling in dental pulp tissue of carious human teeth through the prism of single-cell RNA sequencing International Journal of Oral Science, Vol. 15 Continue to DOI
Thimios A. Mitsiadis, Pierfrancesco Pagella, Terence D. Capellini, Moya Meredith Smith (2023) The Notch-mediated circuitry in the evolution and generation of new cell lineages: the tooth model Cellular and Molecular Life Sciences (CMLS), Vol. 80, Article 182 Continue to DOI
Pierfrancesco Pagella, Simon Söderholm, Anna Nordin, Gianluca Zambanini, Valeria Ghezzi, Amaia Jauregi Miguel, Claudio Cantù (2023) The time-resolved genomic impact of Wnt/(3-catenin signaling CELL SYSTEMS, Vol. 14, p. 563-581.e7 Continue to DOI
Anna Nordin, Gianluca Zambanini, Pierfrancesco Pagella, Claudio Cantù (2023) The CUT & RUN suspect list of problematic regions of the genome Genome Biology, Vol. 24, Article 185 Continue to DOI
Simon Söderholm, Amaia Jauregi Miguel, Pierfrancesco Pagella, Valeria Ghezzi, Gianluca Zambanini, Anna Nordin, Claudio Cantù (2023) Single-cell response to Wnt signaling activation reveals uncoupling of Wnt target gene expression Experimental Cell Research, Vol. 429, Article 113646 Continue to DOI

2022

Thimios A. Mitsiadis, Lucia Jimenez-Rojo, Anamaria Balic, Silvio Weber, Paul Saftig, Pierfrancesco Pagella (2022) Adam10-dependent Notch signaling establishes dental epithelial cell boundaries required for enamel formation iScience, Vol. 25, p. 105154-105154, Article 105154 Continue to DOI
Gianluca Zambanini, Anna Nordin, Mattias Jonasson, Pierfrancesco Pagella, Claudio Cantù (2022) A new CUT&RUN low volume-urea (LoV-U) protocol optimized for transcriptional co-factors uncovers Wnt/beta-catenin tissue-specific genomic targets Development, Vol. 149, Article dev201124 Continue to DOI
Chai Foong Lai, Juliet Shen, Anamaria Balic, Pierfrancesco Pagella, Martin E. Schwab, Thimios A. Mitsiadis (2022) Nogo-A Regulates the Fate of Human Dental Pulp Stem Cells toward Osteogenic, Adipogenic, and Neurogenic Differentiation Cells, Vol. 11, Article 3415 Continue to DOI

2021

Pierfrancesco Pagella, Laura de Vargas Roditi, Bernd Stadlinger, Andreas E. Moor, Thimios A. Mitsiadis (2021) A single-cell atlas of human teeth iScience, Vol. 24, p. 102405-102405, Article 102405 Continue to DOI

2020

Pierfrancesco Pagella, Shayee Miran, Estrela Neto, Ivan Martin, Meriem Lamghari, Thimios A. Mitsiadis (2020) Human dental pulp stem cells exhibit enhanced properties in comparison to human bone marrow stem cells on neurites outgrowth The FASEB Journal, Vol. 34, p. 5499-5511 Continue to DOI

CV

2024-present
Associate professor, Department of physics, chemistry and biology, Division of biophysics and bioengineering, Linköping University, Linköping, Sweden

2021-2023 
Postdoctoral research Fellow, Wallenberg Center for Molecular Medicine (WCMM) and Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Linköpings University, Linköping, Sweden

2017-2021
Lecturer/Senior Scientist (Oberassistent), Institute of Oral Biology, University of Zurich, Zurich, Switzerland.

04/2018 
Visiting scientist, Weill Cornell Medical College, New York City, NY, U.S.A.

2015-2017
Postdoctoral Fellow, Institute of Oral Biology, University of Zurich, Zurich, Switzerland.

10/2012
Visiting student, Center of Biomedical Engineering (INEB), University of Porto, Porto, Portugal.

2011-2015
PhD. Molecular Life Sciences PhD Program, ETH/University of Zurich. Institute of Oral Biology, University of Zurich, Zurich, Switzerland.

07-11/2011
Research Associate, Group Prof. S. K. Nicolis, Department of Biology and Biotechnologies, Università degli Studi di Milano-Bicocca, Milan, Italy.

2010-2011
Visiting Student, Institute for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany.

2008-2011
MSc. In Biology (110/110 cum laude), Università degli Studi di Milano Bicocca, Milan, Italy.

2005-2008
BSc. In Biological Sciences (110/110), Università degli Studi di Milano-Bicocca, Milan, Italy.

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Organisation

Laboratory of molecular materials

We are a multidisciplinary team with a passion for science. Our research is focused on design and development of molecules, soft materials and hybrid nanoscale components and devices for a wide range of biomedical applications.
cells and atoms

Biophysics and bioengineering (BBIOBIO)

We use and develop concepts and tools from physics and chemistry to solve problems of biological and biomedical relevance, and the activities span from basic to applied research.

Department of Physics, Chemistry and Biology (IFM)

Undergraduate teaching and research in the areas of biology, chemistry, materials and applied physics and theory and modelling are conducted at this department.

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