Simon Söderholm

Postdoc

Publications

2026

Xiangyu Qiao, Vanessa William Toma, Jing Wang, Ángel Herraiz-Adillo, Simon Söderholm, Daniel Berglind, Susanna Calling, Bledar Daka, Mats Martinell, Frida Bergman, Pontus Henriksson, Bijar Ghafouri, Martin Ulander, Carl Johan Östgren, Claudio Cantù, Wen Zhong, Fredrik Iredahl (2026)

Genetic predisposition to coffee consumption and the association with the early risk of atherosclerosis Scientific Reports, Vol. 16, Article 9652 (Article in journal)

https://dx.doi.org/10.1038/s41598-026-44122-2

Simon Söderholm, Martin Ulander, Vanessa William Toma, Sara Kaufmann, Xiangyu Qiao, Daniel Berglind, Susanna Calling, Bledar Daka, Ludger Grote, Mats Martinell, Frida Bergman, Pontus Henriksson, Carl Johan Östgren, Wen Zhong, Claudio Cantù, Fredrik Iredahl (2026)

Habitual coffee consumption poorly correlates with sleep quality and daytime sleepiness: A cross-sectional study PLOS ONE, Vol. 21, Article e0344479 (Article in journal)

https://dx.doi.org/10.1371/journal.pone.0344479

2025

Amaia Jauregi Miguel, Simon Söderholm, Tamina Weiss, Anna Nordin, Valeria Ghezzi, Salome M. Brutsch, Pierfrancesco Pagella, Yorick van de Grift, Gianluca Zambanini, Jacopo Ulisse, Alessandro Mattia, Ruslan Deviatiiarov, Elena Faustini, Lavanya Moparthi, Wenjing Zhong, Bergthor Björnsson, Per A Sandström, Erik Lundqvist, Francisca Lottersberger, Stefan Koch, Andreas E. Moor, Xiao-Feng Sun, Eleonore von Castelmur, Guojun Shengo, Claudio Cantù (2025)

The developmental factor TBX3 engages with the Wnt/ß-catenin transcriptional complex in colorectal cancer to regulate metastasis genes Proceedings of the National Academy of Sciences of the United States of America, Vol. 122, Article 2419691122 (Article in journal)

https://dx.doi.org/10.1073/pnas.2419691122

2023

Simon Söderholm (2023)

Exploring the tissue-specific nature of the Wnt cell signaling system: The complex world of cell communication and the search for the Achilles heel of cancer (Doctoral thesis, comprehensive summary)

https://dx.doi.org/10.3384/9789180753173

Pierfrancesco Pagella, Simon Söderholm, Anna Nordin, Gianluca Zambanini, Valeria Ghezzi, Amaia Jauregi Miguel, Claudio Cantù (2023)

The time-resolved genomic impact of Wnt/(3-catenin signaling CELL SYSTEMS, Vol. 14, p. 563-581.e7 (Article in journal)

https://dx.doi.org/10.1016/j.cels.2023.06.004

Research

The Cantù Lab - Genome Regulation in Development and Disease

The Cantù Lab at LiU is focused on one important goal: to discover the mechanisms of genome regulation that drive cell differentiation and specialization during embryonic development.

Organisation

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

News

Two male researchers in front of a computer.

Mechanism in embryonic development makes cancer aggressive

Tumour cells in colorectal cancer exploit an important signalling pathway that normally controls embryo development. Researchers have now shown how a protein that controls limb development make colorectal cancer cells more likely to spread.

Claudio Cantú and Simon Söderholm discuss the results.

Researchers shed new light on the inner workings of stem cells

Embryonic stem cells can give rise to every cell type in the body. A team of researchers has now identified a cellular mechanism that is important for the ability of these cells to maintain their state as stem cells.