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Johan D Söderholm


The role of mucosal barrier function in the initiation of intestinal inflammation

Inflammatory bowel diseases (IBD) are characterized by severe chronic intestinal inflammation bearing huge impact on the quality of life

Incidence is high and escalating, and current treatments lack in efficacy and safety. Our overall aim is to elucidate mechanisms of epithelial barrier function, its role in interacting with commensal bacteria, and how this communication can be converted to the induction of IBD.

The studies will be based on our specific expertise and unique methodology (micro systems for studies of gut physiology in endoscopic biopsies; availability to inflamed and normal human intestinal mucosa), complemented with know-how from international and national partners to guarantee proficiency in all details. Recent original findings from our laboratory have demonstrated neuropeptide-releasing eosinophils as a previously missing link in the regulation of the epithelial barrier in ulcerative colitis. The importance of the follicle-associated epithelium (FAE) in Crohn¿s disease has also been established.

In the planned projects we anticipate providing novel data on neuro-immune interaction with gut microbiota and probiotics at the frontline, i.e. the intestinal barrier (including FAE, mast cells, and eosinophils) during inflammation and stress. We will thereby increase the understanding of crucial steps in the pathogenesis of IBD and disease relapse, ultimately leading to novel therapeutic approaches for these debilitating diseases.





Samira Salihovic, Niklas Nystrom, Charlotte Bache-Wiig Mathisen, Robert Kruse, Christine Olbjorn, Svend Andersen, Alexandra J. Noble, Maria Dorn-Rasmussen, Igor Bazov, Gori Perminow, Randi Opheim, Trond Espen Detlie, Gert Huppertz-Hauss, Charlotte R. H. Hedin, Marie Carlson, Lena Ohman, Maria K. Magnusson, Åsa Keita, Johan D Söderholm, Mauro D'Amato, Matej Oresic, Vibeke Wewer, Jack Satsangi, Carl Marten Lindqvist, Johan Burisch, Holm H. Uhlig, Dirk Repsilber, Tuulia Hyotylainen, Marte Lie Hoivik, Jonas Halfvarson (2024) Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease Nature Communications, Vol. 15, Article 4567 Continue to DOI


Maria Ling Lundström, Christer Peterson, Maria Lampinen, Charlotte R. H. Hedin, Åsa Keita, Robert Kruse, Maria K. Magnusson, Carl Mårten Lindqvist, Dirk Repsilber, Mauro D'Amato, Henrik Hjortswang, Hans Strid, Anders Rönnblom, Johan D Söderholm, Lena Öhman, Per Venge, Jonas Halfvarson, Marie Carlson (2023) Fecal Biomarkers of Neutrophil and Eosinophil Origin Reflect the Response to Biological Therapy and Corticosteroids in Patients With Inflammatory Bowel Disease Clinical and Translational Gastroenterology, Vol. 14, Article e00605 Continue to DOI
R. Kalla, A. T. Adams, J. K. Nowak, D. Bergemalm, S. Vatn, N. A. Ventham, N. A. Kennedy, P. Ricanek, J. Lindstrom, Johan D Söderholm, M. Pierik, M. DAmato, F. Gomollon, C. Olbjorn, R. Richmond, C. L. Relton, J. Jahnsen, M. H. Vatn, J. Halfvarson, J. Satsangi (2023) Analysis of Systemic Epigenetic Alterations in Inflammatory Bowel Disease: Defining Geographical, Genetic and Immune-Inflammatory influences on the Circulating Methylome Journal of Crohn's & Colitis, Vol. 17, p. 170-184 Continue to DOI

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