Photo of Sofie Nyström

Sofie Nyström

Associate Professor, Docent

Prions and plaques

Presentation

Amyloid and Prion Polymorphism

(Abstract from my docent lecture held 14 June 2018)

Proteins are the work horses of the cell and are crucial to most of the chemistry and transport ongoing in any living organism. In order to perform its duty, the protein has to be active. To meet this requirement proteins acquire their native state. Most proteins adapt a unique three dimensional fold, others are natively disordered. However, sometimes proteins leave the native state form a misfolded state. This can be detrimental to the host cell, the host organ and ultimately the host organism.

Plaque


A subclass of misfolded states are known as amyloids. Amyloids are large depositions of well-structured bundles of misfolded proteins. They can be found in any organ of the body and over 30 proteins are known to be associated with amyloid disease in humans. Some of these amyloids have infectious properties due to self-propagation. Among the infectious amyloids, prions are the most well-known. Prions became infamous during the mad cow disease (BSE) epidemic in the 1980ies and the cases of human Creutzfeldt-Jakob disease that followed in its trail.

My research focuses on delineating differences in amyloid structure - amyloid polymorphism - using a combination of recombinant expressed proteins, animal models of disease, biophysical techniques and novel fluorescent probes. It is of utter importance to understand the differences of these structures. Prion strains and their characteristics are good examples of the impact of structural polymorphism on disease progression. A molecular understanding of the amyloid structures, what dictates their formation and rearrangement and what amyloid species are most malignant for the host will facilitate design of new diagnostic tools and more adequate and precise treatment regimens.

Publications

2023

Per Hammarström, Sofie Nyström (2023) Viruses and amyloids-a vicious liaison Prion, Vol. 17, p. 82-104 Continue to DOI

2022

Frederic Lerouge, Elodie Ong, Hugo Rositi, Francis Mpambani, Lise-Prune Berner, Radu Bolbos, Cecile Olivier, Francoise Peyrin, Vinu K. Apputukan, Cyrille Monnereau, Chantal Andraud, Frederic Chaput, Yves Berthezene, Bettina Braun, Mathias Jucker, Andreas Åslund, Sofie Nyström, Per Hammarström, Peter Nilsson, Mikael Lindgren, Marlene Wiart, Fabien Chauveau, Stephane Parola (2022) In vivo targeting and multimodal imaging of cerebral amyloid-beta aggregates using hybrid GdF3 nanoparticles Nanomedicine, Vol. 17, p. 2173-2187 Continue to DOI
Johan Larsson, Sofie Nyström, Per Hammarström (2022) HSP10 as a Chaperone for Neurodegenerative Amyloid Fibrils Frontiers in Neuroscience, Vol. 16, Article 902600 Continue to DOI
Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M. Tijms, Hao Li, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Johan Gobom, Susanne Frykman, Misaki Sekiguchi, Ryo Fujioka, Naoto Watamura, Hiroki Sasaguri, Sofie Nyström, Per Hammarström, Takaomi C. Saido, Vesna Jelic, Stina Syvanen, Henrik Zetterberg, Bengt Winblad, Jonas Bergquist, Pieter Jelle Visser, Per Nilsson (2022) Increased CSF-decorin predicts brain pathological changes driven by Alzheimers A beta amyloidosis Acta neuropathologica communications, Vol. 10, Article 96 Continue to DOI
Sofie Nyström, Per Hammarström (2022) Amyloidogenesis of SARS-CoV-2 Spike Protein br Journal of the American Chemical Society, Vol. 144, p. 8945-8950 Continue to DOI

News

My prion research is based on biophysical studies of recombinant human prion protein (HuPrP) as well as prion proteins from other species.

The prion work is performed in our P3** lab, situated next door to our regular lab environment.

In our strive to understand formation of plaques and aggregates in a number of different protein misfolding disease, such as Alzheimer´s disease and AA amyloidosis we use fluorescence microscopy with both conventional probes and novel probes developed in the lab of Peter Nilsson. This in combination with exploration of proteins from recombinant sources gives insight in propagation of different amyloid species in the affected tissue.

Publications

2023

Per Hammarström, Sofie Nyström (2023) Viruses and amyloids-a vicious liaison Prion, Vol. 17, p. 82-104 Continue to DOI

2022

Frederic Lerouge, Elodie Ong, Hugo Rositi, Francis Mpambani, Lise-Prune Berner, Radu Bolbos, Cecile Olivier, Francoise Peyrin, Vinu K. Apputukan, Cyrille Monnereau, Chantal Andraud, Frederic Chaput, Yves Berthezene, Bettina Braun, Mathias Jucker, Andreas Åslund, Sofie Nyström, Per Hammarström, Peter Nilsson, Mikael Lindgren, Marlene Wiart, Fabien Chauveau, Stephane Parola (2022) In vivo targeting and multimodal imaging of cerebral amyloid-beta aggregates using hybrid GdF3 nanoparticles Nanomedicine, Vol. 17, p. 2173-2187 Continue to DOI
Johan Larsson, Sofie Nyström, Per Hammarström (2022) HSP10 as a Chaperone for Neurodegenerative Amyloid Fibrils Frontiers in Neuroscience, Vol. 16, Article 902600 Continue to DOI
Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M. Tijms, Hao Li, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Johan Gobom, Susanne Frykman, Misaki Sekiguchi, Ryo Fujioka, Naoto Watamura, Hiroki Sasaguri, Sofie Nyström, Per Hammarström, Takaomi C. Saido, Vesna Jelic, Stina Syvanen, Henrik Zetterberg, Bengt Winblad, Jonas Bergquist, Pieter Jelle Visser, Per Nilsson (2022) Increased CSF-decorin predicts brain pathological changes driven by Alzheimers A beta amyloidosis Acta neuropathologica communications, Vol. 10, Article 96 Continue to DOI
Sofie Nyström, Per Hammarström (2022) Amyloidogenesis of SARS-CoV-2 Spike Protein br Journal of the American Chemical Society, Vol. 144, p. 8945-8950 Continue to DOI

2021

He Liu, Chae Kim, Tracy Haldiman, Christina J. Sigurdson, Sofie Nyström, Peter Nilsson, Mark L. Cohen, Thomas Wisniewski, Per Hammarström, Jiri G. Safar (2021) Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimers disease Journal of Biological Chemistry, Vol. 297, Article 101267 Continue to DOI

2020

Marcus Bäck, Robert Selegård, Yogesh Todarwal, Sofie Nyström, Patrick Norman, Mathieu Linares, Per Hammarström, Mikael Lindgren, Peter Nilsson (2020) Tyrosine Side-Chain Functionalities at Distinct Positions Determine the Chirooptical Properties and Supramolecular Structures of Pentameric Oligothiophenes ChemistryOpen, Vol. 9, p. 1100-1108 Continue to DOI
Alexander Sandberg, Helen Ling, Marla Gearing, Beth Dombroski, Laura Cantwell, Lea RBibo, Allan Levey, Gerard D. Schellenberg, John Hardy, Nicholas Wood, Josefin Fernius, Sofie Nyström, Samuel Svensson, Stefan Thor, Per Hammarström, Tamas Revesz, Kin Y. Mok (2020) Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R Neurobiology of Disease, Vol. 146, Article 105079 Continue to DOI
Keisuke Yuzu, Mikael Lindgren, Sofie Nyström, Jun Zhang, Wakako Mori, Risako Kunitomi, Terumasa Nagase, Keiichi Iwaya, Per Hammarström, Tamotsu Zako (2020) Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity RSC Advances, Vol. 10, p. 37721-37727 Continue to DOI
Alejandro M. Sevillano, Patricia Aguilar-Calvo, Timothy D. Kurt, Jessica A. Lawrence, Katrin Soldau, Thu H. Nam, Taylor Schumann, Donald P. Pizzo, Sofie Nyström, Biswa Choudhury, Hermann Altmeppen, Jeffrey D. Esko, Markus Glatzel, Peter Nilsson, Christina J. Sigurdson (2020) Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease Journal of Clinical Investigation, Vol. 130, p. 1350-1362 Continue to DOI

2019

Rajesh Mishra, Mathias Elgland, Afshan Begum, Timmy Fyrner, Peter Konradsson, Sofie Nyström, Per Hammarström (2019) Impact of N-glycosylation site variants during human PrP aggregation and fibril nucleation Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1867, p. 909-921 Continue to DOI
Maria Jonson, Sofie Nyström, Alexander Sandberg, Marcus Carlback, Wojciech Michno, Jorg Hanrieder, Annika Starkenberg, K. Peter, Peter Nilsson, Stefan Thor, Per Hammarström (2019) Amyloid fibril polymorphism and cell-specific toxicity in vivo Amyloid: Journal of Protein Folding Disorders, Vol. 26, p. 136-137 Continue to DOI
Wojciech Michno, Sofie Nyström, Patrick Wehrli, Tammaryn Lashley, Gunnar Brinkmalm, Laurent Guerard, Stina Syvanen, Dag Sehlin, Ibrahim Kaya, Dimitri Brinet, Peter Nilsson, Per Hammarström, Kaj Blennow, Henrik Zetterberg, Jorg Hanrieder (2019) Pyroglutamation of amyloid-x-42 (Ax-42) followed by A1-40 deposition underlies plaque polymorphism in progressing Alzheimers disease pathology Journal of Biological Chemistry, Vol. 294, p. 6719-6732 Continue to DOI
Jun Zhang, Audun Konsmo, Alexander Sandberg, Xiongyu Wu, Sofie Nyström, Ulrike Obermuller, Bettina M. Wegenast-Braun, Peter Konradsson, Mikael Lindgren, Per Hammarström (2019) Phenolic Bis-styrylbenzo[c]-1,2,5-thiadiazoles as Probes for Fluorescence Microscopy Mapping of A beta Plaque Heterogeneity Journal of Medicinal Chemistry, Vol. 62, p. 2038-2048 Continue to DOI

2018

Alexander Sandberg, Sofie Nyström (2018) Purification and Fibrillation of Recombinant Human Amyloid-ß, Prion Protein, and Tau Under Native Conditions Amyloid Proteins: Methods and Protocols, p. 147-166 Continue to DOI
Jun Zhang, Jun Wang, Alexander Sandberg, Xiongyu Wu, Sofie Nyström, Harry III LeVine, Peter Konradsson, Per Hammarström, Bo Durbeej, Mikael Lindgren (2018) Intramolecular Proton and Charge Transfer of Pyrene-based trans-Stilbene Salicylic Acids Applied to Detection of Aggregated Proteins. ChemPhysChem, Vol. 19, p. 3001-3009 Continue to DOI
Chao Wang, Igor A. Iashchishyn, Jonathan Pansieri, Sofie Nyström, Oxana Klementieva, John Kara, Istvan Horvath, Roman Moskalenko, Reza Rofougaran, Gunnar Gouras, Gabor G. Kovacs, S. K. Shankar, Ludmilla A. Morozova-Roche (2018) S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimers Disease Scientific Reports, Vol. 8, Article 12836 Continue to DOI
Jason D. Ulrich, Tyler K. Ulland, Thomas E. Mahan, Sofie Nyström, Peter Nilsson, Wilbur M. Song, Yingyue Zhou, Mariska Reinartz, Seulah Choi, Hong Jiang, Floy R. Stewart, Elise Anderson, Yaming Wang, Marco Colonna, David M. Holtzman (2018) ApoE facilitates the microglial response to amyloid plaque pathology Journal of Experimental Medicine, Vol. 215, p. 1047-1058 Continue to DOI
Wojciech Michno, Ibrahim Kaya, Sofie Nyström, Laurent Guerard, Peter Nilsson, Per Hammarström, Kaj Blennow, Henrik Zetterberg, Jorg Hanrieder (2018) Multimodal Chemical Imaging of Amyloid Plaque Polymorphism Reveals A beta Aggregation Dependent Anionic Lipid Accumulations and Metabolism Analytical Chemistry, Vol. 90, p. 8130-8138 Continue to DOI
Jun Zhang, Alexander Sandberg, Audun Konsmo, Xiongyu Wu, Sofie Nyström, Peter Nilsson, Peter Konradsson, Harry III LeVine, Mikael Lindgren, Per Hammarström (2018) Detection and Imaging of A beta 1-42 and Tau Fibrils by Redesigned Fluorescent X-34 Analogues Chemistry - A European Journal, Vol. 24, p. 7210-7216 Continue to DOI