Fotografi av Sofie Nyström

Sofie Nyström

Universitetslektor, Docent

Prioner och proteinbeläggningar

Presentation

Min forskning kretsar kring prioner och proteinbeläggningar.

För mer information, vänligen se den engelskspråkiga sidan.

Publikationer

2024

Lovisa Johansson, Alexander Sandberg, Sofie Nyström, Per Hammarström, Martin Hallbeck (2024) Amyloid beta 1-40 and 1-42 fibril ratios and maturation level cause conformational differences with minimal impact on autophagy and cytotoxicity Journal of Neurochemistry, Vol. 168, s. 3308-3322 (Artikel i tidskrift) Vidare till DOI
Farjana Parvin, Samuel Haglund, Bettina Wegenast-Braun, Mathias Jucker, Takashi Saito, Takaomi C. Saido, Peter Nilsson, Per Nilsson, Sofie Nyström, Per Hammarström (2024) Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and AppNL-F Mice ACS Chemical Neuroscience, Vol. 15, s. 2058-2069 (Artikel i tidskrift) Vidare till DOI

2023

Per Hammarström, Sofie Nyström (2023) Viruses and amyloids-a vicious liaison Prion, Vol. 17, s. 82-104 (Artikel, forskningsöversikt) Vidare till DOI

2022

Frederic Lerouge, Elodie Ong, Hugo Rositi, Francis Mpambani, Lise-Prune Berner, Radu Bolbos, Cecile Olivier, Francoise Peyrin, Vinu K. Apputukan, Cyrille Monnereau, Chantal Andraud, Frederic Chaput, Yves Berthezene, Bettina Braun, Mathias Jucker, Andreas Åslund, Sofie Nyström, Per Hammarström, Peter Nilsson, Mikael Lindgren, Marlene Wiart, Fabien Chauveau, Stephane Parola (2022) In vivo targeting and multimodal imaging of cerebral amyloid-beta aggregates using hybrid GdF3 nanoparticles Nanomedicine, Vol. 17, s. 2173-2187 (Artikel i tidskrift) Vidare till DOI
Johan Larsson, Sofie Nyström, Per Hammarström (2022) HSP10 as a Chaperone for Neurodegenerative Amyloid Fibrils Frontiers in Neuroscience, Vol. 16, Artikel 902600 (Artikel i tidskrift) Vidare till DOI

Nyheter

Publikationslista

2024

Lovisa Johansson, Alexander Sandberg, Sofie Nyström, Per Hammarström, Martin Hallbeck (2024) Amyloid beta 1-40 and 1-42 fibril ratios and maturation level cause conformational differences with minimal impact on autophagy and cytotoxicity Journal of Neurochemistry, Vol. 168, s. 3308-3322 (Artikel i tidskrift) Vidare till DOI
Farjana Parvin, Samuel Haglund, Bettina Wegenast-Braun, Mathias Jucker, Takashi Saito, Takaomi C. Saido, Peter Nilsson, Per Nilsson, Sofie Nyström, Per Hammarström (2024) Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and AppNL-F Mice ACS Chemical Neuroscience, Vol. 15, s. 2058-2069 (Artikel i tidskrift) Vidare till DOI

2023

Per Hammarström, Sofie Nyström (2023) Viruses and amyloids-a vicious liaison Prion, Vol. 17, s. 82-104 (Artikel, forskningsöversikt) Vidare till DOI

2022

Frederic Lerouge, Elodie Ong, Hugo Rositi, Francis Mpambani, Lise-Prune Berner, Radu Bolbos, Cecile Olivier, Francoise Peyrin, Vinu K. Apputukan, Cyrille Monnereau, Chantal Andraud, Frederic Chaput, Yves Berthezene, Bettina Braun, Mathias Jucker, Andreas Åslund, Sofie Nyström, Per Hammarström, Peter Nilsson, Mikael Lindgren, Marlene Wiart, Fabien Chauveau, Stephane Parola (2022) In vivo targeting and multimodal imaging of cerebral amyloid-beta aggregates using hybrid GdF3 nanoparticles Nanomedicine, Vol. 17, s. 2173-2187 (Artikel i tidskrift) Vidare till DOI
Johan Larsson, Sofie Nyström, Per Hammarström (2022) HSP10 as a Chaperone for Neurodegenerative Amyloid Fibrils Frontiers in Neuroscience, Vol. 16, Artikel 902600 (Artikel i tidskrift) Vidare till DOI
Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M. Tijms, Hao Li, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Johan Gobom, Susanne Frykman, Misaki Sekiguchi, Ryo Fujioka, Naoto Watamura, Hiroki Sasaguri, Sofie Nyström, Per Hammarström, Takaomi C. Saido, Vesna Jelic, Stina Syvanen, Henrik Zetterberg, Bengt Winblad, Jonas Bergquist, Pieter Jelle Visser, Per Nilsson (2022) Increased CSF-decorin predicts brain pathological changes driven by Alzheimers A beta amyloidosis Acta neuropathologica communications, Vol. 10, Artikel 96 (Artikel i tidskrift) Vidare till DOI
Sofie Nyström, Per Hammarström (2022) Amyloidogenesis of SARS-CoV-2 Spike Protein br Journal of the American Chemical Society, Vol. 144, s. 8945-8950 (Artikel i tidskrift) Vidare till DOI

2021

He Liu, Chae Kim, Tracy Haldiman, Christina J. Sigurdson, Sofie Nyström, Peter Nilsson, Mark L. Cohen, Thomas Wisniewski, Per Hammarström, Jiri G. Safar (2021) Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimers disease Journal of Biological Chemistry, Vol. 297, Artikel 101267 (Artikel i tidskrift) Vidare till DOI

2020

Marcus Bäck, Robert Selegård, Yogesh Todarwal, Sofie Nyström, Patrick Norman, Mathieu Linares, Per Hammarström, Mikael Lindgren, Peter Nilsson (2020) Tyrosine Side-Chain Functionalities at Distinct Positions Determine the Chirooptical Properties and Supramolecular Structures of Pentameric Oligothiophenes ChemistryOpen, Vol. 9, s. 1100-1108 (Artikel i tidskrift) Vidare till DOI
Alexander Sandberg, Helen Ling, Marla Gearing, Beth Dombroski, Laura Cantwell, Lea RBibo, Allan Levey, Gerard D. Schellenberg, John Hardy, Nicholas Wood, Josefin Fernius, Sofie Nyström, Samuel Svensson, Stefan Thor, Per Hammarström, Tamas Revesz, Kin Y. Mok (2020) Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R Neurobiology of Disease, Vol. 146, Artikel 105079 (Artikel i tidskrift) Vidare till DOI
Keisuke Yuzu, Mikael Lindgren, Sofie Nyström, Jun Zhang, Wakako Mori, Risako Kunitomi, Terumasa Nagase, Keiichi Iwaya, Per Hammarström, Tamotsu Zako (2020) Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity RSC Advances, Vol. 10, s. 37721-37727 (Artikel i tidskrift) Vidare till DOI
Alejandro M. Sevillano, Patricia Aguilar-Calvo, Timothy D. Kurt, Jessica A. Lawrence, Katrin Soldau, Thu H. Nam, Taylor Schumann, Donald P. Pizzo, Sofie Nyström, Biswa Choudhury, Hermann Altmeppen, Jeffrey D. Esko, Markus Glatzel, Peter Nilsson, Christina J. Sigurdson (2020) Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease Journal of Clinical Investigation, Vol. 130, s. 1350-1362 (Artikel i tidskrift) Vidare till DOI

2019

Rajesh Mishra, Mathias Elgland, Afshan Begum, Timmy Fyrner, Peter Konradsson, Sofie Nyström, Per Hammarström (2019) Impact of N-glycosylation site variants during human PrP aggregation and fibril nucleation Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1867, s. 909-921 (Artikel i tidskrift) Vidare till DOI
Maria Jonson, Sofie Nyström, Alexander Sandberg, Marcus Carlback, Wojciech Michno, Jorg Hanrieder, Annika Starkenberg, K. Peter, Peter Nilsson, Stefan Thor, Per Hammarström (2019) Amyloid fibril polymorphism and cell-specific toxicity in vivo Amyloid: Journal of Protein Folding Disorders, Vol. 26, s. 136-137 (Artikel i tidskrift) Vidare till DOI
Wojciech Michno, Sofie Nyström, Patrick Wehrli, Tammaryn Lashley, Gunnar Brinkmalm, Laurent Guerard, Stina Syvanen, Dag Sehlin, Ibrahim Kaya, Dimitri Brinet, Peter Nilsson, Per Hammarström, Kaj Blennow, Henrik Zetterberg, Jorg Hanrieder (2019) Pyroglutamation of amyloid-x-42 (Ax-42) followed by A1-40 deposition underlies plaque polymorphism in progressing Alzheimers disease pathology Journal of Biological Chemistry, Vol. 294, s. 6719-6732 (Artikel i tidskrift) Vidare till DOI
Jun Zhang, Audun Konsmo, Alexander Sandberg, Xiongyu Wu, Sofie Nyström, Ulrike Obermuller, Bettina M. Wegenast-Braun, Peter Konradsson, Mikael Lindgren, Per Hammarström (2019) Phenolic Bis-styrylbenzo[c]-1,2,5-thiadiazoles as Probes for Fluorescence Microscopy Mapping of A beta Plaque Heterogeneity Journal of Medicinal Chemistry, Vol. 62, s. 2038-2048 (Artikel i tidskrift) Vidare till DOI

2018

Alexander Sandberg, Sofie Nyström (2018) Purification and Fibrillation of Recombinant Human Amyloid-ß, Prion Protein, and Tau Under Native Conditions Amyloid Proteins: Methods and Protocols, s. 147-166 (Kapitel i bok, del av antologi) Vidare till DOI
Jun Zhang, Jun Wang, Alexander Sandberg, Xiongyu Wu, Sofie Nyström, Harry III LeVine, Peter Konradsson, Per Hammarström, Bo Durbeej, Mikael Lindgren (2018) Intramolecular Proton and Charge Transfer of Pyrene-based trans-Stilbene Salicylic Acids Applied to Detection of Aggregated Proteins. ChemPhysChem, Vol. 19, s. 3001-3009 (Artikel i tidskrift) Vidare till DOI
Chao Wang, Igor A. Iashchishyn, Jonathan Pansieri, Sofie Nyström, Oxana Klementieva, John Kara, Istvan Horvath, Roman Moskalenko, Reza Rofougaran, Gunnar Gouras, Gabor G. Kovacs, S. K. Shankar, Ludmilla A. Morozova-Roche (2018) S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimers Disease Scientific Reports, Vol. 8, Artikel 12836 (Artikel i tidskrift) Vidare till DOI
Jason D. Ulrich, Tyler K. Ulland, Thomas E. Mahan, Sofie Nyström, Peter Nilsson, Wilbur M. Song, Yingyue Zhou, Mariska Reinartz, Seulah Choi, Hong Jiang, Floy R. Stewart, Elise Anderson, Yaming Wang, Marco Colonna, David M. Holtzman (2018) ApoE facilitates the microglial response to amyloid plaque pathology Journal of Experimental Medicine, Vol. 215, s. 1047-1058 (Artikel i tidskrift) Vidare till DOI