Sofia Nyström

Associate Professor, Docent

My research aims to advance our understanding of the pathophysiology of inborn errors of immunity and autoimmune disorders to support precision medicine approaches.

Presentation

As an Associate Professor of Clinical Immunology and Senior Consultant in Clinical Immunology and Transfusion Medicine, I bridge the gap between research and clinical practice. My research focuses on investigating various aspects of immune dysregulation. Clinically, I contribute to the diagnosis of patients with both inborn and acquired immunodeficiencies.

Publications

2026

Agnes Winsa, Ingemar Lagerlöf, Fredrik Ellin, Mats Fredrikson, Åsa Nilsdotter-Augustinsson, Marcus Bendtsen, Jorg Cammenga, Sofia Nyström (2026)

The association between inborn errors of immunity and Hodgkin lymphoma-A register-based case-control study in Sweden British Journal of Haematology (Article in journal)

https://dx.doi.org/10.1111/bjh.70743

Cecilia Svanberg, Ravi Prasad Mukku, Sabri Özkan Besler, Francis Hopkins, Christopher Sjöwall, Sofia Nyström, Esaki M. Shankar, Marie Larsson (2026)

HIV-1 derived oligonucleotides induce a type I IFN/STING dependent immune suppression reversible by targeting IFNARI PLoS Pathogens, Vol. 22, Article e1013868 (Article in journal)

https://dx.doi.org/10.1371/journal.ppat.1013868

2025

Melissa Govender, Jyotirmoy Das, Francis Hopkins, Cecilia Svanberg, Johan Nordgren, Marie Hagbom, Jonas Klingström, Åsa Nilsdotter-Augustinsson, Yean K. Yong, Vijayakumar Velu, Sivadoss Raju, Johanna Sjöwall, Esaki M. Shankar, Sofia Nyström, Marie Larsson (2025)

Altered DNA Methylation Pattern Contributes to Differential Epigenetic Immune Signaling in the Upper Respiratory Airway of Unvaccinated COVID-19 Patients Cells, Vol. 14, Article 1673 (Article in journal)

https://dx.doi.org/10.3390/cells14211673

Pontus Hedberg, Lisa Blixt, Sandra Eketorp Sylvan, Isabela Killander Moller, Hannes Lindahl, Fredrik Kahn, Åsa Nilsdotter-Augustinsson, Mats Fredrikson, Sofia Nyström, Peter Bergman, Christina Carlander, Soo Aleman, Pontus Nauclér, Anders Österborg, Lotta Hansson (2025)

Outcomes of the COVID-19 pandemic in chronic lymphocytic leukemia: focus on the very early period and Omicron era Blood Advances, Vol. 9, p. 3170-3181 (Article in journal)

https://dx.doi.org/10.1182/bloodadvances.2024015260

Ramona Fust, Sofia Nyström, Britt Åkerlind, Åsa Nilsdotter-Augustinsson, Christina Petersson (2025)

Experience of the COVID-19 Pandemic in the Care of Patients with Predominantly Antibody Deficiencies (PADs)-A Qualitative Study with Perspectives from Both Patients and Nurses Nursing Reports, Vol. 15, Article 104 (Article in journal)

https://dx.doi.org/10.3390/nursrep15030104

Research

My research on inborn errors of immunity spans from immunological mechanisms to population-level studies. Additionally, I investigate precision medicine approaches in multiple sclerosis and immune responses to viral infections, working closely with other researchers at Linköping University.

Education

Medical Program

Organisation

Medical Inflammation and Infection Center, MIIC

Medical Inflammation and Infection Center, MIIC, research focus is on infections and inflammatory conditions, which are major concerns for human health.

News

Female researcher studies a cell plate in a laboratory.

Long-term effects on the immune system following COVID-19

The more severe the COVID-19 infection, the slower the recovery of immune cells which are necessary for the activation of the immune system. Six months after severe COVID-19, a negative impact on several types of immune cells can still be seen.

Popular education important for asylum seekers’ social inclusion

Committed teachers in the popular adult education sector are quietly making a huge contribution with helping asylum seekers into Swedish society. And it’s not just educational, it's also social and humanitarian. All according to two fresh LiU studies.