Unn Örtegren Kugelberg

Principal Research E

Publications

2026

Unn Örtegren Kugelberg, Anna Erkstam, Kiseko Shionoya, Anders Blomqvist (2026)

EP3 is the only prostaglandin E receptor required for lipopolysaccharide-induced fever Brain, Behavior, and Immunity - Health, Vol. 57, Article 101344 (Article in journal)

https://dx.doi.org/10.1016/j.bbih.2026.101344

Anna Asratian, Signe Isacson, Unn Örtegren Kugelberg, Colum Walsh, Anita Öst (2026)

Breed-specific divergence in boar sperm regulatory profiles involves piRNA and mitochondrial small RNAs Cellular and Molecular Life Sciences (CMLS), Vol. 83, Article 243 (Article in journal)

https://dx.doi.org/10.1007/s00018-026-06244-8

2025

Signe Isacson, Kajsa Karlsson, Stefan Zalavary, Anna Asratian, Unn Örtegren Kugelberg, Susanne Liffner, Anita Öst (2025)

Small RNA in sperm-Paternal contributions to human embryo development Nature Communications, Vol. 16, Article 6571 (Article in journal)

https://dx.doi.org/10.1038/s41467-025-62015-2

Josefine Jonsson, Alexander Perfilyev, Unn Örtegren Kugelberg, Signe Skog, Axel Lindstrom, Sabrina Ruhrmann, Jones K. Ofori, Karl Bacos, Tina Ronn, Anita Öst, Charlotte Ling (2025)

Impact of excess sugar on the whole genome DNA methylation pattern in human sperm Epigenomics, Vol. 17, p. 89-104 (Article in journal)

https://dx.doi.org/10.1080/17501911.2024.2439782

2023

Signe Skog, Lovisa Örkenby, Unn Örtegren Kugelberg, Anita Öst, Daniel Nätt (2023)

Seqpac: a framework for sRNA-seq analysis in R using sequence-based counts Bioinformatics, Vol. 39, Article btad144 (Article in journal)

https://dx.doi.org/10.1093/bioinformatics/btad144

News

Diet has rapid effects on sperm quality

Sperm are influenced by diet, and the effects arise rapidly. This is the conclusion of a study in which healthy young men were fed a diet rich in sugar. The study, published in PLOS Biology, gives new insight into the function of sperm.

Four circles in a row each with different contens. The first one containing healthy food, the second one a sperm, the third one a fertilized egg, the fourt an unborn Child.

Decoding the Molecular Language of Sperm

Sperm carry much more than DNA. Our research aims to decode the molecular language of sperm - how environmental information is encoded, transmitted to the embryo and shapes fertility, early development and lifelong health.